Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a review
This review focuses on the field of endometrial cancer. Since 2020, there have been 417,367 new cases of endometrial cancer diagnosed globally and 97,370 deaths reported. Endometrial cancer ranks second in terms of incidence among female genital malignancies and third in terms of mortality among gyn...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595638/full |
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| author | Bingyan Liang Bingyan Liang Jia Tan Jia Li Xiaolan Wang Genlin Li Huanhuan Li Ting Li Hong Gao Hong Gao Hong Gao |
| author_facet | Bingyan Liang Bingyan Liang Jia Tan Jia Li Xiaolan Wang Genlin Li Huanhuan Li Ting Li Hong Gao Hong Gao Hong Gao |
| author_sort | Bingyan Liang |
| collection | DOAJ |
| description | This review focuses on the field of endometrial cancer. Since 2020, there have been 417,367 new cases of endometrial cancer diagnosed globally and 97,370 deaths reported. Endometrial cancer ranks second in terms of incidence among female genital malignancies and third in terms of mortality among gynecological cancers. The stage, grade, and histological subtype of endometrial cancer were closely correlated with the risk of recurrence and prognosis for survival. Meanwhile, endometrial cancer exhibits significant biological heterogeneity. The complex interactions among the reproductive tract, host cells, and the microbial environment may harbor novel disease mechanisms. In this review, we provide an overview of the epidemiological characteristics, major risk factors, histological and molecular subtypes of endometrial cancer, as well as explore the associations between the female reproductive tract microbiome, immunity, and cancer progression. We also identify the specific roles of different cytokines in the pathophysiology of endometrial cancer. By integrating findings from diverse research fields, this comprehensive review offers an in-depth understanding of the multidimensional nature of endometrial cancer and highlights the significant potential and promising avenues that microbiological factors present for advancing future cancer research and guiding the development of innovative therapeutic strategies. |
| format | Article |
| id | doaj-art-e9983c1bd7bb428cbf8e653fc65e4cf8 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e9983c1bd7bb428cbf8e653fc65e4cf82025-08-20T03:32:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15956381595638Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a reviewBingyan Liang0Bingyan Liang1Jia Tan2Jia Li3Xiaolan Wang4Genlin Li5Huanhuan Li6Ting Li7Hong Gao8Hong Gao9Hong Gao10School of Nursing, University of South China, Hengyang, Hunan, ChinaScientific Research Department, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaDepartment of Neonatology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaOperating Room, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaCenter for a Combination of Obstetrics and Gynecology and Reproductive Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaCenter for a Combination of Obstetrics and Gynecology and Reproductive Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaScientific Research Department, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaOttawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, CanadaSchool of Nursing, University of South China, Hengyang, Hunan, ChinaThis review focuses on the field of endometrial cancer. Since 2020, there have been 417,367 new cases of endometrial cancer diagnosed globally and 97,370 deaths reported. Endometrial cancer ranks second in terms of incidence among female genital malignancies and third in terms of mortality among gynecological cancers. The stage, grade, and histological subtype of endometrial cancer were closely correlated with the risk of recurrence and prognosis for survival. Meanwhile, endometrial cancer exhibits significant biological heterogeneity. The complex interactions among the reproductive tract, host cells, and the microbial environment may harbor novel disease mechanisms. In this review, we provide an overview of the epidemiological characteristics, major risk factors, histological and molecular subtypes of endometrial cancer, as well as explore the associations between the female reproductive tract microbiome, immunity, and cancer progression. We also identify the specific roles of different cytokines in the pathophysiology of endometrial cancer. By integrating findings from diverse research fields, this comprehensive review offers an in-depth understanding of the multidimensional nature of endometrial cancer and highlights the significant potential and promising avenues that microbiological factors present for advancing future cancer research and guiding the development of innovative therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595638/fullendometrial cancerreproductive tract microbiomeimmune responseinflammationdysbiosis |
| spellingShingle | Bingyan Liang Bingyan Liang Jia Tan Jia Li Xiaolan Wang Genlin Li Huanhuan Li Ting Li Hong Gao Hong Gao Hong Gao Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a review Frontiers in Immunology endometrial cancer reproductive tract microbiome immune response inflammation dysbiosis |
| title | Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a review |
| title_full | Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a review |
| title_fullStr | Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a review |
| title_full_unstemmed | Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a review |
| title_short | Epidemiology, molecular typing, microbiome-immune interactions and treatment strategies of endometrial cancer: a review |
| title_sort | epidemiology molecular typing microbiome immune interactions and treatment strategies of endometrial cancer a review |
| topic | endometrial cancer reproductive tract microbiome immune response inflammation dysbiosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595638/full |
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