Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease
Obstructive sleep apnea is recognized as having high prevalence and causing remarkable cardiovascular risk. Coronary artery disease has been associated with obstructive sleep apnea in many reports. The pathophysiology of coronary artery disease in obstructive sleep apnea patients probably includes t...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/405827 |
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| author | Carlos Carpio Rodolfo Álvarez-Sala Francisco García-Río |
| author_facet | Carlos Carpio Rodolfo Álvarez-Sala Francisco García-Río |
| author_sort | Carlos Carpio |
| collection | DOAJ |
| description | Obstructive sleep apnea is recognized as having high prevalence and causing remarkable cardiovascular risk. Coronary artery disease has been associated with obstructive sleep apnea in many reports. The pathophysiology of coronary artery disease in obstructive sleep apnea patients probably includes the activation of multiple mechanisms, as the sympathetic activity, endothelial dysfunction, atherosclerosis, and systemic hypertension. Moreover, chronic intermittent hypoxia and oxidative stress have an important role in the pathogenesis of coronary disease and are also fundamental to the development of atherosclerosis and other comorbidities present in coronary artery diseases such as lipid metabolic disorders. Interestingly, the prognosis of patients with coronary artery disease has been associated with obstructive sleep apnea and the severity of sleep disordered breathing may have a direct relationship with the morbidity and mortality of patients with coronary diseases. Nevertheless, treatment with CPAP may have important effects, and recent reports have described the benefits of obstructive sleep apnea treatment on the recurrence of acute heart ischaemic events in patients with coronary artery disease. |
| format | Article |
| id | doaj-art-e99398bc227a406d84b8dd06dbdb43a0 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-e99398bc227a406d84b8dd06dbdb43a02025-02-03T01:01:46ZengWileyPulmonary Medicine2090-18362090-18442013-01-01201310.1155/2013/405827405827Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart DiseaseCarlos Carpio0Rodolfo Álvarez-Sala1Francisco García-Río2Servicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), 28046 Madrid, SpainServicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), 28046 Madrid, SpainServicio de Neumología, Hospital Universitario La Paz, Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), 28046 Madrid, SpainObstructive sleep apnea is recognized as having high prevalence and causing remarkable cardiovascular risk. Coronary artery disease has been associated with obstructive sleep apnea in many reports. The pathophysiology of coronary artery disease in obstructive sleep apnea patients probably includes the activation of multiple mechanisms, as the sympathetic activity, endothelial dysfunction, atherosclerosis, and systemic hypertension. Moreover, chronic intermittent hypoxia and oxidative stress have an important role in the pathogenesis of coronary disease and are also fundamental to the development of atherosclerosis and other comorbidities present in coronary artery diseases such as lipid metabolic disorders. Interestingly, the prognosis of patients with coronary artery disease has been associated with obstructive sleep apnea and the severity of sleep disordered breathing may have a direct relationship with the morbidity and mortality of patients with coronary diseases. Nevertheless, treatment with CPAP may have important effects, and recent reports have described the benefits of obstructive sleep apnea treatment on the recurrence of acute heart ischaemic events in patients with coronary artery disease.http://dx.doi.org/10.1155/2013/405827 |
| spellingShingle | Carlos Carpio Rodolfo Álvarez-Sala Francisco García-Río Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease Pulmonary Medicine |
| title | Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease |
| title_full | Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease |
| title_fullStr | Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease |
| title_full_unstemmed | Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease |
| title_short | Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease |
| title_sort | epidemiological and pathogenic relationship between sleep apnea and ischemic heart disease |
| url | http://dx.doi.org/10.1155/2013/405827 |
| work_keys_str_mv | AT carloscarpio epidemiologicalandpathogenicrelationshipbetweensleepapneaandischemicheartdisease AT rodolfoalvarezsala epidemiologicalandpathogenicrelationshipbetweensleepapneaandischemicheartdisease AT franciscogarciario epidemiologicalandpathogenicrelationshipbetweensleepapneaandischemicheartdisease |