Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress
Acute immobilization stress and its pharmacological correction with mexidol (2-ethyl-6-methyl-3-oxypyridine succinate) were modeled in albino male rats. The drug was administered to animals in dose 100 mg/kg before stress exposure with following investigation of content of glutathione and its fract...
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Zaporizhzhia State Medical and Pharmaceutical University
2013-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/15587 |
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| author | N. O. Vlasenko |
| author_facet | N. O. Vlasenko |
| author_sort | N. O. Vlasenko |
| collection | DOAJ |
| description | Acute immobilization stress and its pharmacological correction with mexidol (2-ethyl-6-methyl-3-oxypyridine succinate) were modeled in albino male rats. The drug was administered to animals in dose 100 mg/kg before stress exposure with following investigation of content of glutathione and its fractions (GSH, GSSG) in different terms of post-stress period. It is shown that mexidol enhances the level of reduced glutathione (GSH) in erythrocytes as well as in myeloid tissue in terms from 3 hrs to 5 days after the stress. It also regularly increases common glutathione concentration in erythrocytes in alarm stage of stress-syndrome (3-24 hrs). Such effect of mexidol, probably, is the consequence of its direct antioxidant action which lowers the load on physiological antioxidant system and promotes the maintenance of normal functional activity of erythron’s central and peripheral parts in stress. |
| format | Article |
| id | doaj-art-e991b85d16134c4a93c8f123968e96e5 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2013-06-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-e991b85d16134c4a93c8f123968e96e52025-08-20T02:03:43ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102013-06-0131013http://dx.doi.org/10.14739/2310-1210.2013.2.15587Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stressN. O. VlasenkoAcute immobilization stress and its pharmacological correction with mexidol (2-ethyl-6-methyl-3-oxypyridine succinate) were modeled in albino male rats. The drug was administered to animals in dose 100 mg/kg before stress exposure with following investigation of content of glutathione and its fractions (GSH, GSSG) in different terms of post-stress period. It is shown that mexidol enhances the level of reduced glutathione (GSH) in erythrocytes as well as in myeloid tissue in terms from 3 hrs to 5 days after the stress. It also regularly increases common glutathione concentration in erythrocytes in alarm stage of stress-syndrome (3-24 hrs). Such effect of mexidol, probably, is the consequence of its direct antioxidant action which lowers the load on physiological antioxidant system and promotes the maintenance of normal functional activity of erythron’s central and peripheral parts in stress.http://zmj.zsmu.edu.ua/article/view/15587mexidolglutathionestresserythrocytesbone marrow |
| spellingShingle | N. O. Vlasenko Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress Zaporožskij Medicinskij Žurnal mexidol glutathione stress erythrocytes bone marrow |
| title | Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress |
| title_full | Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress |
| title_fullStr | Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress |
| title_full_unstemmed | Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress |
| title_short | Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress |
| title_sort | glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress |
| topic | mexidol glutathione stress erythrocytes bone marrow |
| url | http://zmj.zsmu.edu.ua/article/view/15587 |
| work_keys_str_mv | AT novlasenko glutathionecontentinerythrocytesandbonemarrowofanimalsinmexidoluseundertheconditionsofacutestress |