Pathogenesis of obstetric and perinatal complications in metabolic syndrome
Aim. To describe a pathogenetic rationale for obstetric and perinatal complications associated with metabolic syndrome. Materials and Methods. This is a descriptive review based on original research and review articles on obstetric and perinatal complications in the context of metabolic syndrome, pu...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Kemerovo State Medical University
2025-06-01
|
| Series: | Фундаментальная и клиническая медицина |
| Subjects: | |
| Online Access: | https://fcm.kemsmu.ru/jour/article/view/1021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849344530186240000 |
|---|---|
| author | K. A. Gulenkova A. A. Orazmuradov E. V. Mukovnikova M. B. Khamoshina |
| author_facet | K. A. Gulenkova A. A. Orazmuradov E. V. Mukovnikova M. B. Khamoshina |
| author_sort | K. A. Gulenkova |
| collection | DOAJ |
| description | Aim. To describe a pathogenetic rationale for obstetric and perinatal complications associated with metabolic syndrome. Materials and Methods. This is a descriptive review based on original research and review articles on obstetric and perinatal complications in the context of metabolic syndrome, published between 2016 and 2025 and indexed in PubMed, ScienceDirect, and eLibrary databases. The following research methods were employed: internet-based analysis, content analysis, historical method, and descriptive-analytical approach. Results. Obesity and metabolic syndrome have a negative impact on maternal and fetal outcomes. Adipose tissue functions as an active endocrine organ that regulates vascular, metabolic, and inflammatory processes across multiple organ systems, thereby affecting obstetric and perinatal outcomes. Conclusion. The obesity epidemic has drawn attention to adipose tissue as a critical regulator of systemic nutrient and energy homeostasis. In metabolic syndrome, adipose tissue must adapt to excessive lipid load through a variety of strategies, including increasing adipocyte size and number, altering immune cell composition, and reshaping lipid metabolism. Failure to adequately adapt to increased nutritional load results in adipose tissue dysfunction which triggers a cascade of lipotoxic effects on other organs, leading to insulin resistance, diabetes mellitus, and related metabolic complications. Adipose tissue dysfunction is significantly accelerated by the additional metabolic load imposed by pregnancy |
| format | Article |
| id | doaj-art-e99074a3eab043bb9ecf1a6045200b82 |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2025-06-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-e99074a3eab043bb9ecf1a6045200b822025-08-20T03:42:39ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412025-06-01102678110.23946/2500-0764-2025-10-2-67-81477Pathogenesis of obstetric and perinatal complications in metabolic syndromeK. A. Gulenkova0A. A. Orazmuradov1E. V. Mukovnikova2M. B. Khamoshina3Peoples' Friendship University of Russia named after Patrice LumumbaPeoples' Friendship University of Russia named after Patrice LumumbaPeoples' Friendship University of Russia named after Patrice LumumbaPeoples' Friendship University of Russia named after Patrice LumumbaAim. To describe a pathogenetic rationale for obstetric and perinatal complications associated with metabolic syndrome. Materials and Methods. This is a descriptive review based on original research and review articles on obstetric and perinatal complications in the context of metabolic syndrome, published between 2016 and 2025 and indexed in PubMed, ScienceDirect, and eLibrary databases. The following research methods were employed: internet-based analysis, content analysis, historical method, and descriptive-analytical approach. Results. Obesity and metabolic syndrome have a negative impact on maternal and fetal outcomes. Adipose tissue functions as an active endocrine organ that regulates vascular, metabolic, and inflammatory processes across multiple organ systems, thereby affecting obstetric and perinatal outcomes. Conclusion. The obesity epidemic has drawn attention to adipose tissue as a critical regulator of systemic nutrient and energy homeostasis. In metabolic syndrome, adipose tissue must adapt to excessive lipid load through a variety of strategies, including increasing adipocyte size and number, altering immune cell composition, and reshaping lipid metabolism. Failure to adequately adapt to increased nutritional load results in adipose tissue dysfunction which triggers a cascade of lipotoxic effects on other organs, leading to insulin resistance, diabetes mellitus, and related metabolic complications. Adipose tissue dysfunction is significantly accelerated by the additional metabolic load imposed by pregnancyhttps://fcm.kemsmu.ru/jour/article/view/1021metabolic syndromeobesitypathogenesispreeclampsiagestational diabetes mellitusepigeneticsperinatal mortality |
| spellingShingle | K. A. Gulenkova A. A. Orazmuradov E. V. Mukovnikova M. B. Khamoshina Pathogenesis of obstetric and perinatal complications in metabolic syndrome Фундаментальная и клиническая медицина metabolic syndrome obesity pathogenesis preeclampsia gestational diabetes mellitus epigenetics perinatal mortality |
| title | Pathogenesis of obstetric and perinatal complications in metabolic syndrome |
| title_full | Pathogenesis of obstetric and perinatal complications in metabolic syndrome |
| title_fullStr | Pathogenesis of obstetric and perinatal complications in metabolic syndrome |
| title_full_unstemmed | Pathogenesis of obstetric and perinatal complications in metabolic syndrome |
| title_short | Pathogenesis of obstetric and perinatal complications in metabolic syndrome |
| title_sort | pathogenesis of obstetric and perinatal complications in metabolic syndrome |
| topic | metabolic syndrome obesity pathogenesis preeclampsia gestational diabetes mellitus epigenetics perinatal mortality |
| url | https://fcm.kemsmu.ru/jour/article/view/1021 |
| work_keys_str_mv | AT kagulenkova pathogenesisofobstetricandperinatalcomplicationsinmetabolicsyndrome AT aaorazmuradov pathogenesisofobstetricandperinatalcomplicationsinmetabolicsyndrome AT evmukovnikova pathogenesisofobstetricandperinatalcomplicationsinmetabolicsyndrome AT mbkhamoshina pathogenesisofobstetricandperinatalcomplicationsinmetabolicsyndrome |