Nerve regeneration by interferon intervention in aging brain
Abstract Neural stem cells (NSCs) are shielded from viral infection by interferon (IFN) defense. As individuals age, activation of NSC decreases with a significant decline of stemness marker Sex‐determining region Y box 2 (Sox2) while IFN signaling enhances (Kalamakis et al, 2019). Given that low‐le...
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| Format: | Article |
| Language: | English |
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Springer Nature
2023-03-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202217307 |
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| author | Fanwen Wang Duanqing Pei |
| author_facet | Fanwen Wang Duanqing Pei |
| author_sort | Fanwen Wang |
| collection | DOAJ |
| description | Abstract Neural stem cells (NSCs) are shielded from viral infection by interferon (IFN) defense. As individuals age, activation of NSC decreases with a significant decline of stemness marker Sex‐determining region Y box 2 (Sox2) while IFN signaling enhances (Kalamakis et al, 2019). Given that low‐level type‐I IFN under normal physiological conditions can promote dormant hematopoietic stem cell differentiation (Baldridge et al, 2010), whether there is an inner connection between IFN signaling and NSC function remains elusive. In this issue of EMBO Molecular Medicine, Carvajal Ibanez et al (2023) reveal that IFN‐β, a type‐I interferon, induces cell‐type‐specific interferon‐stimulated genes (ISGs) and regulates global protein synthesis by orchestrating mTOR1 activity and stem cell cycle that retain NSCs at the G0 phase and repress Sox2 expression. As a consequence, NSCs exit the activation state and become inclined to differentiation. |
| format | Article |
| id | doaj-art-e98fc2f0d4e34fa8a1ffb9c2569c4588 |
| institution | DOAJ |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-e98fc2f0d4e34fa8a1ffb9c2569c45882025-08-20T03:05:53ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842023-03-011541310.15252/emmm.202217307Nerve regeneration by interferon intervention in aging brainFanwen Wang0Duanqing Pei1Laboratory of Cell Fate Control, School of Life Sciences, Westlake UniversityLaboratory of Cell Fate Control, School of Life Sciences, Westlake UniversityAbstract Neural stem cells (NSCs) are shielded from viral infection by interferon (IFN) defense. As individuals age, activation of NSC decreases with a significant decline of stemness marker Sex‐determining region Y box 2 (Sox2) while IFN signaling enhances (Kalamakis et al, 2019). Given that low‐level type‐I IFN under normal physiological conditions can promote dormant hematopoietic stem cell differentiation (Baldridge et al, 2010), whether there is an inner connection between IFN signaling and NSC function remains elusive. In this issue of EMBO Molecular Medicine, Carvajal Ibanez et al (2023) reveal that IFN‐β, a type‐I interferon, induces cell‐type‐specific interferon‐stimulated genes (ISGs) and regulates global protein synthesis by orchestrating mTOR1 activity and stem cell cycle that retain NSCs at the G0 phase and repress Sox2 expression. As a consequence, NSCs exit the activation state and become inclined to differentiation.https://doi.org/10.15252/emmm.202217307 |
| spellingShingle | Fanwen Wang Duanqing Pei Nerve regeneration by interferon intervention in aging brain EMBO Molecular Medicine |
| title | Nerve regeneration by interferon intervention in aging brain |
| title_full | Nerve regeneration by interferon intervention in aging brain |
| title_fullStr | Nerve regeneration by interferon intervention in aging brain |
| title_full_unstemmed | Nerve regeneration by interferon intervention in aging brain |
| title_short | Nerve regeneration by interferon intervention in aging brain |
| title_sort | nerve regeneration by interferon intervention in aging brain |
| url | https://doi.org/10.15252/emmm.202217307 |
| work_keys_str_mv | AT fanwenwang nerveregenerationbyinterferoninterventioninagingbrain AT duanqingpei nerveregenerationbyinterferoninterventioninagingbrain |