KPop: accurate and scalable comparative analysis of microbial genomes by sequence embeddings

Abstract Here we introduce KPop, a novel versatile method based on full k-mer spectra and dataset-specific transformations, through which thousands of assembled or unassembled microbial genomes can be quickly compared. Unlike MinHash-based methods that produce distances and have lower resolution, KP...

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Bibliographic Details
Main Authors: Xavier Didelot, Paolo Ribeca
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-025-03585-8
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