Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report
ABSTRACT Canine oral papillomatosis, caused by canine papilloma virus 1, is a benign condition primarily affecting young or immunosuppressed dogs. While most cases regress spontaneously, severe cases often require surgical intervention due to extensive lesions and associated discomforts. However, su...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Veterinary Medicine and Science |
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| Online Access: | https://doi.org/10.1002/vms3.70453 |
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| author | Jungyeon Yong Myeongjee Kwon Haerin Yoon Sungin Lee Kyung‐Mee Park |
| author_facet | Jungyeon Yong Myeongjee Kwon Haerin Yoon Sungin Lee Kyung‐Mee Park |
| author_sort | Jungyeon Yong |
| collection | DOAJ |
| description | ABSTRACT Canine oral papillomatosis, caused by canine papilloma virus 1, is a benign condition primarily affecting young or immunosuppressed dogs. While most cases regress spontaneously, severe cases often require surgical intervention due to extensive lesions and associated discomforts. However, surgical excision is associated with a high risk of recurrence, necessitating adjuvant therapies. This report presents the case of a 1‐year‐old German Shepherd with severe oral papilloma unresponsive to prior treatments, managed through surgical excision followed by topical mitomycin C (MMC) application. MMC, applied intraoperatively and during follow‐up, effectively prevented recurrence over a 1‐year period. This case demonstrates the potential of MMC as an effective adjuvant therapy for severe canine oral papillomatosis, providing a novel approach in veterinary medicine. |
| format | Article |
| id | doaj-art-e98b4c9c5daf4376ae62d26a237cd3bb |
| institution | Kabale University |
| issn | 2053-1095 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj-art-e98b4c9c5daf4376ae62d26a237cd3bb2025-08-20T03:55:53ZengWileyVeterinary Medicine and Science2053-10952025-07-01114n/an/a10.1002/vms3.70453Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case ReportJungyeon Yong0Myeongjee Kwon1Haerin Yoon2Sungin Lee3Kyung‐Mee Park4College of Veterinary Medicine Chungbuk National University Cheongju Republic of KoreaCollege of Veterinary Medicine Chungbuk National University Cheongju Republic of KoreaCollege of Veterinary Medicine Chungbuk National University Cheongju Republic of KoreaCollege of Veterinary Medicine Chungbuk National University Cheongju Republic of KoreaCollege of Veterinary Medicine Chungbuk National University Cheongju Republic of KoreaABSTRACT Canine oral papillomatosis, caused by canine papilloma virus 1, is a benign condition primarily affecting young or immunosuppressed dogs. While most cases regress spontaneously, severe cases often require surgical intervention due to extensive lesions and associated discomforts. However, surgical excision is associated with a high risk of recurrence, necessitating adjuvant therapies. This report presents the case of a 1‐year‐old German Shepherd with severe oral papilloma unresponsive to prior treatments, managed through surgical excision followed by topical mitomycin C (MMC) application. MMC, applied intraoperatively and during follow‐up, effectively prevented recurrence over a 1‐year period. This case demonstrates the potential of MMC as an effective adjuvant therapy for severe canine oral papillomatosis, providing a novel approach in veterinary medicine.https://doi.org/10.1002/vms3.70453mitomycin Cpapillomarecurrence |
| spellingShingle | Jungyeon Yong Myeongjee Kwon Haerin Yoon Sungin Lee Kyung‐Mee Park Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report Veterinary Medicine and Science mitomycin C papilloma recurrence |
| title | Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report |
| title_full | Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report |
| title_fullStr | Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report |
| title_full_unstemmed | Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report |
| title_short | Topical Mitomycin C Application Following Surgical Excision in Canine Oral Papilloma: A Case Report |
| title_sort | topical mitomycin c application following surgical excision in canine oral papilloma a case report |
| topic | mitomycin C papilloma recurrence |
| url | https://doi.org/10.1002/vms3.70453 |
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