Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis
AL amyloidosis complicating monoclonal gammopathy of undetermined significance (MGUS) has usually a predominant glomerular deposition of lambda light chain. Heavy proteinuria is one of its cardinal manifestations. A 78-year-old man with a 9-year history of IgG kappa light-chain-MGUS and normal urine...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/573650 |
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| author | Yijuan Sun Amarpreet Sandhu Darlene Gabaldon Jonathan Danaraj Karen S. Servilla Antonios H. Tzamaloukas |
| author_facet | Yijuan Sun Amarpreet Sandhu Darlene Gabaldon Jonathan Danaraj Karen S. Servilla Antonios H. Tzamaloukas |
| author_sort | Yijuan Sun |
| collection | DOAJ |
| description | AL amyloidosis complicating monoclonal gammopathy of undetermined significance (MGUS) has usually a predominant glomerular deposition of lambda light chain. Heavy proteinuria is one of its cardinal manifestations. A 78-year-old man with a 9-year history of IgG kappa light-chain-MGUS and normal urine protein excretion developed severe renal failure. Serum levels of kappa light chain and serum IgG had been stable while proteinuria was absent throughout the nine-year period. For the first eight years, he had stable stage III chronic kidney disease attributed to bladder outlet obstruction secondary to prostatic malignancy. In the last year, he developed progressive serum creatinine elevation, without any increase in the serum or urine levels of paraproteins or any sign of malignancy. Renal ultrasound and furosemide renogram showed no evidence of urinary obstruction. Renal biopsy revealed AL amyloidosis, with reactivity exclusive for kappa light chains, affecting predominantly the vessels and the interstitium. Glomerular involvement was minimal. Melphalan and prednisone were initiated. However, renal function continues deteriorating. Deposition of AL kappa amyloidosis developing during the course of MGUS predominantly in the wall of the renal vessels and the renal interstitium, while the involvement of the glomeruli is minimal, leads to progressive renal failure and absence of proteinuria. Renal biopsy is required to detect both the presence and the sites of deposition of renal AL kappa light chain amyloidosis. |
| format | Article |
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| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Case Reports in Nephrology |
| spelling | doaj-art-e98ac80174af4f03a463048499fa5d212025-02-03T01:30:26ZengWileyCase Reports in Nephrology2090-66412090-665X2012-01-01201210.1155/2012/573650573650Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa AmyloidosisYijuan Sun0Amarpreet Sandhu1Darlene Gabaldon2Jonathan Danaraj3Karen S. Servilla4Antonios H. Tzamaloukas5Division of Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, The University of New Mexico School of Medicine and VA Medical Center (111C), 1501 San Pedro SE, Albuquerque, NM 87108, USADivision of Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, The University of New Mexico School of Medicine and VA Medical Center (111C), 1501 San Pedro SE, Albuquerque, NM 87108, USADivision of Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, The University of New Mexico School of Medicine and VA Medical Center (111C), 1501 San Pedro SE, Albuquerque, NM 87108, USADivision of Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, The University of New Mexico School of Medicine and VA Medical Center (111C), 1501 San Pedro SE, Albuquerque, NM 87108, USADivision of Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, The University of New Mexico School of Medicine and VA Medical Center (111C), 1501 San Pedro SE, Albuquerque, NM 87108, USADivision of Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, The University of New Mexico School of Medicine and VA Medical Center (111C), 1501 San Pedro SE, Albuquerque, NM 87108, USAAL amyloidosis complicating monoclonal gammopathy of undetermined significance (MGUS) has usually a predominant glomerular deposition of lambda light chain. Heavy proteinuria is one of its cardinal manifestations. A 78-year-old man with a 9-year history of IgG kappa light-chain-MGUS and normal urine protein excretion developed severe renal failure. Serum levels of kappa light chain and serum IgG had been stable while proteinuria was absent throughout the nine-year period. For the first eight years, he had stable stage III chronic kidney disease attributed to bladder outlet obstruction secondary to prostatic malignancy. In the last year, he developed progressive serum creatinine elevation, without any increase in the serum or urine levels of paraproteins or any sign of malignancy. Renal ultrasound and furosemide renogram showed no evidence of urinary obstruction. Renal biopsy revealed AL amyloidosis, with reactivity exclusive for kappa light chains, affecting predominantly the vessels and the interstitium. Glomerular involvement was minimal. Melphalan and prednisone were initiated. However, renal function continues deteriorating. Deposition of AL kappa amyloidosis developing during the course of MGUS predominantly in the wall of the renal vessels and the renal interstitium, while the involvement of the glomeruli is minimal, leads to progressive renal failure and absence of proteinuria. Renal biopsy is required to detect both the presence and the sites of deposition of renal AL kappa light chain amyloidosis.http://dx.doi.org/10.1155/2012/573650 |
| spellingShingle | Yijuan Sun Amarpreet Sandhu Darlene Gabaldon Jonathan Danaraj Karen S. Servilla Antonios H. Tzamaloukas Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis Case Reports in Nephrology |
| title | Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis |
| title_full | Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis |
| title_fullStr | Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis |
| title_full_unstemmed | Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis |
| title_short | Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance: An Unusual Presentation of AL Kappa Amyloidosis |
| title_sort | development of renal failure without proteinuria in a patient with monoclonal gammopathy of undetermined significance an unusual presentation of al kappa amyloidosis |
| url | http://dx.doi.org/10.1155/2012/573650 |
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