The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation
Perfluorooctanesulfonic acid (PFOS) poses significant health risks from bioaccumulation in humans. Effective strategies for removing bioaccumulated PFOS are limited. This study systematically investigated the association between PFOS reduction and cruciferous vegetable intake through a cross-section...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-01-01
|
| Series: | Environmental Chemistry and Ecotoxicology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590182625000980 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849236698434633728 |
|---|---|
| author | Xiaobing Zhai Junjun Ji Jing Wang Jinji Bai Xuechen Zhao Wenjie Zhang Ruyan Lv Xuan Deng Qixiu Li Weiyu Meng Qianqian Zhang Jinyuan Zhao Jiajing Cui Li Yu Chi Kin Lam Chan Zhang Henry H.Y. Tong Yuefei Wang Xicheng Song Kaiqiang Wang Junfeng Li Kefeng Li |
| author_facet | Xiaobing Zhai Junjun Ji Jing Wang Jinji Bai Xuechen Zhao Wenjie Zhang Ruyan Lv Xuan Deng Qixiu Li Weiyu Meng Qianqian Zhang Jinyuan Zhao Jiajing Cui Li Yu Chi Kin Lam Chan Zhang Henry H.Y. Tong Yuefei Wang Xicheng Song Kaiqiang Wang Junfeng Li Kefeng Li |
| author_sort | Xiaobing Zhai |
| collection | DOAJ |
| description | Perfluorooctanesulfonic acid (PFOS) poses significant health risks from bioaccumulation in humans. Effective strategies for removing bioaccumulated PFOS are limited. This study systematically investigated the association between PFOS reduction and cruciferous vegetable intake through a cross-section analysis of 2258 NHANES participants, followed by a 14-day randomized clinical trial (RCT) validation (n = 38). Plasma lipidomics and reverse docking explored the metabolic changes and potential targets related to PFOS elimination from broccoli intake. In NHANES, frequent cruciferous intake was associated with lower odds of high serum PFOS (OR and 95 % CI: 0.63 [0.41–0.96] after adjustment of all known covariates). The RCT demonstrated a significant decrease in serum PFOS after broccoli-orange juice intervention (median reduction = 5.9 %, P = 0.003), but not after orange juice alone (median reduction = 0.3 %, P = 0.153). Lipdiomics revealed PFOS-reduction related changes in steroid, ganglioside, ceramide metabolism and the urea cycle. Target fishing identified strong binding between the pregnane X receptor (PXR), a regulator of steroid/xenobiotic metabolism, and broccoli bioactives including glucoraphanin and sulforaphane. Overall, these findings have significant implications for developing dietary strategies to mitigate PFOS health risks. |
| format | Article |
| id | doaj-art-e9868e1aec374bd483c7d6cba08d1876 |
| institution | Kabale University |
| issn | 2590-1826 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Environmental Chemistry and Ecotoxicology |
| spelling | doaj-art-e9868e1aec374bd483c7d6cba08d18762025-08-20T04:02:09ZengKeAi Communications Co., Ltd.Environmental Chemistry and Ecotoxicology2590-18262025-01-0171648165810.1016/j.enceco.2025.07.003The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validationXiaobing Zhai0Junjun Ji1Jing Wang2Jinji Bai3Xuechen Zhao4Wenjie Zhang5Ruyan Lv6Xuan Deng7Qixiu Li8Weiyu Meng9Qianqian Zhang10Jinyuan Zhao11Jiajing Cui12Li Yu13Chi Kin Lam14Chan Zhang15Henry H.Y. Tong16Yuefei Wang17Xicheng Song18Kaiqiang Wang19Junfeng Li20Kefeng Li21Faculty of Applied Sciences, Macao Polytechnic University, Macao, ChinaFaculty of Applied Sciences, Macao Polytechnic University, Macao, China; Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, China; Changzhi Key Lab of Functional Imaging for Brain Diseases, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, ChinaDepartment of Critical Care Medicine, Yantai Yuhuangding Hospital, Qingdao University, Shandong, ChinaDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, ChinaSchool of Life Sciences, Shandong University, Shandong, ChinaDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, ChinaDepartment of Critical Care Medicine, Yantai Yuhuangding Hospital, Qingdao University, Shandong, ChinaDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, ChinaDepartment of Critical Care Medicine, Yantai Yuhuangding Hospital, Qingdao University, Shandong, ChinaFaculty of Applied Sciences, Macao Polytechnic University, Macao, ChinaFaculty of Applied Sciences, Macao Polytechnic University, Macao, ChinaDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, ChinaDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, ChinaDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang, ChinaFaculty of Applied Sciences, Macao Polytechnic University, Macao, ChinaDepartment of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, ChinaFaculty of Applied Sciences, Macao Polytechnic University, Macao, ChinaNational Key Laboratory of Chinese Medicine Modernization, State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Otolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Shandong, China; Corresponding authors.Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials, School of Pharmacy, Changzhi Medical College, Shanxi, China; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Shanxi, China; Correspondence to: Kaiqiang Wang, School of Pharmacy, Changzhi Medical College, Shanxi, China.Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, China; Changzhi Key Lab of Functional Imaging for Brain Diseases, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, China; Correspondence to: Junfeng Li, Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Shanxi, China.Faculty of Applied Sciences, Macao Polytechnic University, Macao, China; Corresponding authors.Perfluorooctanesulfonic acid (PFOS) poses significant health risks from bioaccumulation in humans. Effective strategies for removing bioaccumulated PFOS are limited. This study systematically investigated the association between PFOS reduction and cruciferous vegetable intake through a cross-section analysis of 2258 NHANES participants, followed by a 14-day randomized clinical trial (RCT) validation (n = 38). Plasma lipidomics and reverse docking explored the metabolic changes and potential targets related to PFOS elimination from broccoli intake. In NHANES, frequent cruciferous intake was associated with lower odds of high serum PFOS (OR and 95 % CI: 0.63 [0.41–0.96] after adjustment of all known covariates). The RCT demonstrated a significant decrease in serum PFOS after broccoli-orange juice intervention (median reduction = 5.9 %, P = 0.003), but not after orange juice alone (median reduction = 0.3 %, P = 0.153). Lipdiomics revealed PFOS-reduction related changes in steroid, ganglioside, ceramide metabolism and the urea cycle. Target fishing identified strong binding between the pregnane X receptor (PXR), a regulator of steroid/xenobiotic metabolism, and broccoli bioactives including glucoraphanin and sulforaphane. Overall, these findings have significant implications for developing dietary strategies to mitigate PFOS health risks.http://www.sciencedirect.com/science/article/pii/S2590182625000980Cruciferous vegetable consumptionPerfluorooctanesulfonic acidRandomized clinical trialCross-sectional designLipidomics |
| spellingShingle | Xiaobing Zhai Junjun Ji Jing Wang Jinji Bai Xuechen Zhao Wenjie Zhang Ruyan Lv Xuan Deng Qixiu Li Weiyu Meng Qianqian Zhang Jinyuan Zhao Jiajing Cui Li Yu Chi Kin Lam Chan Zhang Henry H.Y. Tong Yuefei Wang Xicheng Song Kaiqiang Wang Junfeng Li Kefeng Li The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation Environmental Chemistry and Ecotoxicology Cruciferous vegetable consumption Perfluorooctanesulfonic acid Randomized clinical trial Cross-sectional design Lipidomics |
| title | The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation |
| title_full | The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation |
| title_fullStr | The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation |
| title_full_unstemmed | The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation |
| title_short | The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation |
| title_sort | association between cruciferous vegetable consumption and perfluorooctanesulfonic acid bioaccumulation a cross sectional analysis of the us population and cross country randomized clinical trial validation |
| topic | Cruciferous vegetable consumption Perfluorooctanesulfonic acid Randomized clinical trial Cross-sectional design Lipidomics |
| url | http://www.sciencedirect.com/science/article/pii/S2590182625000980 |
| work_keys_str_mv | AT xiaobingzhai theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT junjunji theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jingwang theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jinjibai theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT xuechenzhao theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT wenjiezhang theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT ruyanlv theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT xuandeng theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT qixiuli theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT weiyumeng theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT qianqianzhang theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jinyuanzhao theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jiajingcui theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT liyu theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT chikinlam theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT chanzhang theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT henryhytong theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT yuefeiwang theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT xichengsong theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT kaiqiangwang theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT junfengli theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT kefengli theassociationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT xiaobingzhai associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT junjunji associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jingwang associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jinjibai associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT xuechenzhao associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT wenjiezhang associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT ruyanlv associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT xuandeng associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT qixiuli associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT weiyumeng associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT qianqianzhang associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jinyuanzhao associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT jiajingcui associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT liyu associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT chikinlam associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT chanzhang associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT henryhytong associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT yuefeiwang associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT xichengsong associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT kaiqiangwang associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT junfengli associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation AT kefengli associationbetweencruciferousvegetableconsumptionandperfluorooctanesulfonicacidbioaccumulationacrosssectionalanalysisoftheuspopulationandcrosscountryrandomizedclinicaltrialvalidation |