RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP
Aim. To study the association of the level (mass) of lipoproteine-associated phospholipase A2 with coronary and carotid atherosclerosis in the patients with essential arterial hypertension in Kirgiz ethnic group.Material and methods. Totally 52 patients studied with arterial hypertension (AH); mean...
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«FIRMA «SILICEA» LLC
2014-11-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/108 |
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| author | A. G. Polupanov Yu. N. Lomteva T. A. Romanova A. S. Dzhumagulova |
| author_facet | A. G. Polupanov Yu. N. Lomteva T. A. Romanova A. S. Dzhumagulova |
| author_sort | A. G. Polupanov |
| collection | DOAJ |
| description | Aim. To study the association of the level (mass) of lipoproteine-associated phospholipase A2 with coronary and carotid atherosclerosis in the patients with essential arterial hypertension in Kirgiz ethnic group.Material and methods. Totally 52 patients studied with arterial hypertension (AH); mean age — 54,9±6,7, of those 26 men and 26 women. CHD, confirmed by exercise tests or coronary arteriography, had 19 patients, atherosclerosis of carotid arteries – 28. All patients underwent height measurement, weight and waist circumference, BP and HR measurement, also measurement of some biochemical values: fibrinogene level, sugar, creatinine of the blood and lipid profile (levels of total cholesterol, LDL, HDL and triglycerides). Measurement of LP-PLA2 was done using “PLAC” test by “DiaDexus” (USA) with immuneturbodimetry method “ELISA”. Duplex scanning of carotid arteries was done with Sequoia-512 by “Accuson” (USA).Results. There was direct correlation of LP-PLA2 correlation with the age (r=0,27; p<0,05), HDL concentration (r=0,30; p<0,05) and LDL (r=0,28; p<0,05) and negative association with triglycerides (r=-0,28; p<0,05). Significant differences by gender in LP-PLA2 were not found (p>0,05). Patients with CHD had higher level oftotal cholesterol (5,64±0,97 mmol/l vs. 5,23±1,33 mmol/l, р=0,057), LDL (3,63±0,89 mmol/l vs. 3,16±0,98 mmol/l, p<0,01), and the mass of LP-PLA2 (296±70 ng/ml vs. 237±76 ng/ml, p<0,005) comparing to the patients with EH and CHD. In multifactorial regression analysis it was shown that only concentration of LP-PLA2 independently associated with CHD among native inhabitants of the Republic (β=0,66; p<0,001). We did not found association of LP-PLA2 with presence and prominence of carotid atherosclerosis and carotid intima-media thickness (p>0,05).Conclusion. In Kirgiz ethnic group there is association of LP-PLA2 with CHD, but not with carotid atherosclerosis. |
| format | Article |
| id | doaj-art-e9824c3c086f4011a65f7a8d82301ef7 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2014-11-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-e9824c3c086f4011a65f7a8d82301ef72025-08-20T03:57:09Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-11-01011515610.15829/1560-4071-2014-11-51-56108RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUPA. G. Polupanov0Yu. N. Lomteva1T. A. Romanova2A. S. Dzhumagulova3National Centre for Cardiology and Therapy n.a. Academician M. Mirrakhimov of the Ministry of Health of Kirgiz Republic, BishkekNational Centre for Cardiology and Therapy n.a. Academician M. Mirrakhimov of the Ministry of Health of Kirgiz Republic, BishkekNational Centre for Cardiology and Therapy n.a. Academician M. Mirrakhimov of the Ministry of Health of Kirgiz Republic, BishkekNational Centre for Cardiology and Therapy n.a. Academician M. Mirrakhimov of the Ministry of Health of Kirgiz Republic, BishkekAim. To study the association of the level (mass) of lipoproteine-associated phospholipase A2 with coronary and carotid atherosclerosis in the patients with essential arterial hypertension in Kirgiz ethnic group.Material and methods. Totally 52 patients studied with arterial hypertension (AH); mean age — 54,9±6,7, of those 26 men and 26 women. CHD, confirmed by exercise tests or coronary arteriography, had 19 patients, atherosclerosis of carotid arteries – 28. All patients underwent height measurement, weight and waist circumference, BP and HR measurement, also measurement of some biochemical values: fibrinogene level, sugar, creatinine of the blood and lipid profile (levels of total cholesterol, LDL, HDL and triglycerides). Measurement of LP-PLA2 was done using “PLAC” test by “DiaDexus” (USA) with immuneturbodimetry method “ELISA”. Duplex scanning of carotid arteries was done with Sequoia-512 by “Accuson” (USA).Results. There was direct correlation of LP-PLA2 correlation with the age (r=0,27; p<0,05), HDL concentration (r=0,30; p<0,05) and LDL (r=0,28; p<0,05) and negative association with triglycerides (r=-0,28; p<0,05). Significant differences by gender in LP-PLA2 were not found (p>0,05). Patients with CHD had higher level oftotal cholesterol (5,64±0,97 mmol/l vs. 5,23±1,33 mmol/l, р=0,057), LDL (3,63±0,89 mmol/l vs. 3,16±0,98 mmol/l, p<0,01), and the mass of LP-PLA2 (296±70 ng/ml vs. 237±76 ng/ml, p<0,005) comparing to the patients with EH and CHD. In multifactorial regression analysis it was shown that only concentration of LP-PLA2 independently associated with CHD among native inhabitants of the Republic (β=0,66; p<0,001). We did not found association of LP-PLA2 with presence and prominence of carotid atherosclerosis and carotid intima-media thickness (p>0,05).Conclusion. In Kirgiz ethnic group there is association of LP-PLA2 with CHD, but not with carotid atherosclerosis.https://russjcardiol.elpub.ru/jour/article/view/108coronary heart diseasecarotid atherosclerosislp-pla2 |
| spellingShingle | A. G. Polupanov Yu. N. Lomteva T. A. Romanova A. S. Dzhumagulova RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP Российский кардиологический журнал coronary heart disease carotid atherosclerosis lp-pla2 |
| title | RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP |
| title_full | RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP |
| title_fullStr | RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP |
| title_full_unstemmed | RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP |
| title_short | RELATIONSHIP OF LIPOPROTEINE-ASSOCIATED PHOSPHOLIPASE A2 WITH CORONARY AND CAROTID ATHEROSCLEROSIS IN KIRGIZ ETHNIC GROUP |
| title_sort | relationship of lipoproteine associated phospholipase a2 with coronary and carotid atherosclerosis in kirgiz ethnic group |
| topic | coronary heart disease carotid atherosclerosis lp-pla2 |
| url | https://russjcardiol.elpub.ru/jour/article/view/108 |
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