A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40%
The aim of this study was to describe gender-related differences in characteristics and mortality in heart failure (HF) patients managed in primary care (PC). We included 1802 hF patients aged 77.5 ± 8.8 years (47% women) with ejection fraction (EF) ≥ 40% from the Swedish Heart Failure (SwedeHF) reg...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Critical Public Health |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09581596.2024.2421966 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850249511871447040 |
|---|---|
| author | Björn Eriksson Per Wändell Ulf Dahlström Per Näsman Lars H. Lund Magnus Edner |
| author_facet | Björn Eriksson Per Wändell Ulf Dahlström Per Näsman Lars H. Lund Magnus Edner |
| author_sort | Björn Eriksson |
| collection | DOAJ |
| description | The aim of this study was to describe gender-related differences in characteristics and mortality in heart failure (HF) patients managed in primary care (PC). We included 1802 hF patients aged 77.5 ± 8.8 years (47% women) with ejection fraction (EF) ≥ 40% from the Swedish Heart Failure (SwedeHF) registry. The patients were divided by gender, and by heart failure with mildly reduced ejection fraction (HFmrEF; EF 40–49%) or heart failure with preserved ejection fraction (HFpEF; EF ≥ 50%). Men included in the study were younger (mean-age 76.4 vs 78.7 years, p < 0.0001) and showed a higher age-adjusted mortality (p < 0.0001). Men more often showed ischemic heart disease, 49% vs. 38% (p < 0.0001), atrial fibrillation, 56% vs. 50%, and diabetes, 25% vs. 17% (both p < 0.01). Women had higher blood pressure compared to men (p < 0.01), more commonly had kidney dysfunction (p < 0.01), and a worse functional capacity (p < 0.01). Cardiovascular diseases were the dominating causes of death in men and women (60% and 56%) but were less dominating in individuals with EF ≥ 50%, especially among women (56% in men vs. 46% in women). Among women with EF ≥ 50%, the mortality was dominated of mixed and unspecified diseases. Other important causes of death were cancer (15%) and chronic obstructive pulmonary disease (13%). Men managed in PC with HF and EF ≥ 40% have a higher age-adjusted mortality than women. Cardiovascular disease is the dominating cause of death in both genders. Other frequent causes of death were malignant tumors and respiratory diseases, illustrating the need to carefully diagnose and treat all associated comorbidities. |
| format | Article |
| id | doaj-art-e980f22671d24d7ba10dac4ae26d838e |
| institution | OA Journals |
| issn | 0958-1596 1469-3682 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Critical Public Health |
| spelling | doaj-art-e980f22671d24d7ba10dac4ae26d838e2025-08-20T01:58:28ZengTaylor & Francis GroupCritical Public Health0958-15961469-36822024-12-0134111310.1080/09581596.2024.2421966A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40%Björn Eriksson0Per Wändell1Ulf Dahlström2Per Näsman3Lars H. Lund4Magnus Edner5Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, SwedenDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, SwedenDepartment of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenCenter for Safety Research, KTH Royal Institute of Technology, Stockholm, SwedenDivision of Medicine, Department of Cardiology, Karolinska University Hospital, Karolinska Institutet, Stockholm, SwedenDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, SwedenThe aim of this study was to describe gender-related differences in characteristics and mortality in heart failure (HF) patients managed in primary care (PC). We included 1802 hF patients aged 77.5 ± 8.8 years (47% women) with ejection fraction (EF) ≥ 40% from the Swedish Heart Failure (SwedeHF) registry. The patients were divided by gender, and by heart failure with mildly reduced ejection fraction (HFmrEF; EF 40–49%) or heart failure with preserved ejection fraction (HFpEF; EF ≥ 50%). Men included in the study were younger (mean-age 76.4 vs 78.7 years, p < 0.0001) and showed a higher age-adjusted mortality (p < 0.0001). Men more often showed ischemic heart disease, 49% vs. 38% (p < 0.0001), atrial fibrillation, 56% vs. 50%, and diabetes, 25% vs. 17% (both p < 0.01). Women had higher blood pressure compared to men (p < 0.01), more commonly had kidney dysfunction (p < 0.01), and a worse functional capacity (p < 0.01). Cardiovascular diseases were the dominating causes of death in men and women (60% and 56%) but were less dominating in individuals with EF ≥ 50%, especially among women (56% in men vs. 46% in women). Among women with EF ≥ 50%, the mortality was dominated of mixed and unspecified diseases. Other important causes of death were cancer (15%) and chronic obstructive pulmonary disease (13%). Men managed in PC with HF and EF ≥ 40% have a higher age-adjusted mortality than women. Cardiovascular disease is the dominating cause of death in both genders. Other frequent causes of death were malignant tumors and respiratory diseases, illustrating the need to carefully diagnose and treat all associated comorbidities.https://www.tandfonline.com/doi/10.1080/09581596.2024.2421966Heart failureHFpEFHFmrEFprimary caregender differences |
| spellingShingle | Björn Eriksson Per Wändell Ulf Dahlström Per Näsman Lars H. Lund Magnus Edner A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40% Critical Public Health Heart failure HFpEF HFmrEF primary care gender differences |
| title | A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40% |
| title_full | A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40% |
| title_fullStr | A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40% |
| title_full_unstemmed | A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40% |
| title_short | A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40% |
| title_sort | higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40 |
| topic | Heart failure HFpEF HFmrEF primary care gender differences |
| url | https://www.tandfonline.com/doi/10.1080/09581596.2024.2421966 |
| work_keys_str_mv | AT bjorneriksson ahighermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT perwandell ahighermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT ulfdahlstrom ahighermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT pernasman ahighermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT larshlund ahighermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT magnusedner ahighermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT bjorneriksson highermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT perwandell highermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT ulfdahlstrom highermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT pernasman highermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT larshlund highermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 AT magnusedner highermortalityinmencomparedtowomenwithheartfailureinprimarycareandejectionfractionequaltoormorethan40 |