Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress
Objective: To determine the possible association between acute fetal stress during labor and maternal blood levels of osteopontin (OPN), white blood cells, sedimentation, and C-reactive protein (CRP). Methods: The study included women with a term pregnancy (37 weeks or more) who had a cesarean sect...
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Galenos Publishing House
2024-07-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/role-of-inflammation-markers-and-osteopontin-in-the-prediction-of-fetal-stress/doi/gmj.2023.3891 |
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| author | Betül Tokgöz Çakır Hande Esra Koca Elif Akkaş Yılmaz Tuncay Küçüközkan |
| author_facet | Betül Tokgöz Çakır Hande Esra Koca Elif Akkaş Yılmaz Tuncay Küçüközkan |
| author_sort | Betül Tokgöz Çakır |
| collection | DOAJ |
| description | Objective: To determine the possible association between acute fetal stress during labor and maternal blood levels of osteopontin (OPN), white blood cells, sedimentation, and C-reactive protein (CRP).
Methods: The study included women with a term pregnancy (37 weeks or more) who had a cesarean section during the active phase of labor. The study included 30 term pregnancies who underwent cesarean section for fetal distress and 30 pregnant women who underwent cesarean section for other indications (prior uterine surgery, head-pelvis incompatibility, large baby, non-progressing plot) as a control group. The levels of OPN and other inflammatory markers (leukocytes, sedimentation, CRP) in the maternal venous blood of 60 pregnant women were compared, and whether there was a significant association between the groups was investigated.
Results: OPN levels in the fetal stress group were higher than those in the control group, and the difference was statistically significant (p=0.008). There was no statistically significant difference in white blood cell, blood sedimentation, and CRP levels between the two groups (p>0.005).
Conclusion: Placental inflammation plays a role in the etiology of fetal stress, and OPN may be released because of fetal stress. The increase in OPN in maternal blood during labor may be an important marker for predicting fetal stress. |
| format | Article |
| id | doaj-art-e980cf60c9384b9387570d631432ae8b |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-e980cf60c9384b9387570d631432ae8b2025-01-16T12:05:42ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-07-0135325525910.12996/gmj.2023.3891Role of Inflammation Markers and Osteopontin in the Prediction of Fetal StressBetül Tokgöz Çakır0https://orcid.org/0000-0003-0202-4981Hande Esra Koca1https://orcid.org/0000-0002-3715-9424Elif Akkaş Yılmaz2https://orcid.org/0000-0002-9555-7340Tuncay Küçüközkan3https://orcid.org/0000-0003-4280-3883Department of Obstetrics and Gynecology University of Health Sciences Türkiye, Dr. Sami Ulus Women’s and Children’s Health Training and Research Hospital, Ankara, TürkiyeDepartment of Obstetrics and Gynecology University of Health Sciences Türkiye, Dr. Sami Ulus Women’s and Children’s Health Training and Research Hospital, Ankara, TürkiyeDepartment of Obstetrics and Gynecology University of Health Sciences Türkiye, Dr. Sami Ulus Women’s and Children’s Health Training and Research Hospital, Ankara, TürkiyeDepartment of Obstetrics and Gynecology University of Health Sciences Türkiye, Dr. Sami Ulus Women’s and Children’s Health Training and Research Hospital, Ankara, TürkiyeObjective: To determine the possible association between acute fetal stress during labor and maternal blood levels of osteopontin (OPN), white blood cells, sedimentation, and C-reactive protein (CRP). Methods: The study included women with a term pregnancy (37 weeks or more) who had a cesarean section during the active phase of labor. The study included 30 term pregnancies who underwent cesarean section for fetal distress and 30 pregnant women who underwent cesarean section for other indications (prior uterine surgery, head-pelvis incompatibility, large baby, non-progressing plot) as a control group. The levels of OPN and other inflammatory markers (leukocytes, sedimentation, CRP) in the maternal venous blood of 60 pregnant women were compared, and whether there was a significant association between the groups was investigated. Results: OPN levels in the fetal stress group were higher than those in the control group, and the difference was statistically significant (p=0.008). There was no statistically significant difference in white blood cell, blood sedimentation, and CRP levels between the two groups (p>0.005). Conclusion: Placental inflammation plays a role in the etiology of fetal stress, and OPN may be released because of fetal stress. The increase in OPN in maternal blood during labor may be an important marker for predicting fetal stress.https://gazimedj.com/articles/role-of-inflammation-markers-and-osteopontin-in-the-prediction-of-fetal-stress/doi/gmj.2023.3891crpc-sectionfetal distressleukocyte countosteopontin |
| spellingShingle | Betül Tokgöz Çakır Hande Esra Koca Elif Akkaş Yılmaz Tuncay Küçüközkan Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress Gazi Medical Journal crp c-section fetal distress leukocyte count osteopontin |
| title | Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress |
| title_full | Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress |
| title_fullStr | Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress |
| title_full_unstemmed | Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress |
| title_short | Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress |
| title_sort | role of inflammation markers and osteopontin in the prediction of fetal stress |
| topic | crp c-section fetal distress leukocyte count osteopontin |
| url | https://gazimedj.com/articles/role-of-inflammation-markers-and-osteopontin-in-the-prediction-of-fetal-stress/doi/gmj.2023.3891 |
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