Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review
The gut microbiome significantly influences the outcomes of pediatric leukemia, particularly in patients undergoing hematopoietic stem cell transplantation (HSCT). Dysbiosis, caused by chemotherapy, antibiotics, and immune system changes, contributes to complications such as graft-versus-host diseas...
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MDPI AG
2025-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/2/166 |
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| author | Samuel Bogdan Todor Cristian Ichim |
| author_facet | Samuel Bogdan Todor Cristian Ichim |
| author_sort | Samuel Bogdan Todor |
| collection | DOAJ |
| description | The gut microbiome significantly influences the outcomes of pediatric leukemia, particularly in patients undergoing hematopoietic stem cell transplantation (HSCT). Dysbiosis, caused by chemotherapy, antibiotics, and immune system changes, contributes to complications such as graft-versus-host disease (GVHD), gastrointestinal issues, and infections. Various microbiome-related interventions, including prebiotics, probiotics, postbiotics, and fecal microbiota transplantation (FMT), have shown potential in mitigating these complications. Specific microbial signatures have been linked to GVHD risk, and interventions like inulin, Lactobacillus, and SCFAs (short-chain fatty acids), particularly butyrate, may help modulate the immune system and improve outcomes. FMT, while showing promising results in restoring microbial balance and alleviating GVHD, still requires careful monitoring due to potential risks in immunocompromised patients. Despite positive findings, more research is needed to optimize microbiome-based therapies and ensure their safety and efficacy in pediatric leukemia care. |
| format | Article |
| id | doaj-art-e97fdc80fb8c4c2d968a53d1b405e3e4 |
| institution | DOAJ |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj-art-e97fdc80fb8c4c2d968a53d1b405e3e42025-08-20T02:44:35ZengMDPI AGChildren2227-90672025-01-0112216610.3390/children12020166Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative ReviewSamuel Bogdan Todor0Cristian Ichim1Faculty of Medicine, University Lucian Blaga of Sibiu, 550024 Sibiu, RomaniaFaculty of Medicine, University Lucian Blaga of Sibiu, 550024 Sibiu, RomaniaThe gut microbiome significantly influences the outcomes of pediatric leukemia, particularly in patients undergoing hematopoietic stem cell transplantation (HSCT). Dysbiosis, caused by chemotherapy, antibiotics, and immune system changes, contributes to complications such as graft-versus-host disease (GVHD), gastrointestinal issues, and infections. Various microbiome-related interventions, including prebiotics, probiotics, postbiotics, and fecal microbiota transplantation (FMT), have shown potential in mitigating these complications. Specific microbial signatures have been linked to GVHD risk, and interventions like inulin, Lactobacillus, and SCFAs (short-chain fatty acids), particularly butyrate, may help modulate the immune system and improve outcomes. FMT, while showing promising results in restoring microbial balance and alleviating GVHD, still requires careful monitoring due to potential risks in immunocompromised patients. Despite positive findings, more research is needed to optimize microbiome-based therapies and ensure their safety and efficacy in pediatric leukemia care.https://www.mdpi.com/2227-9067/12/2/166childhood leukemiagut microbiomefecal microbiota transplanthematopoietic stem-cell transplantgraft-versus-host disease |
| spellingShingle | Samuel Bogdan Todor Cristian Ichim Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review Children childhood leukemia gut microbiome fecal microbiota transplant hematopoietic stem-cell transplant graft-versus-host disease |
| title | Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review |
| title_full | Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review |
| title_fullStr | Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review |
| title_full_unstemmed | Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review |
| title_short | Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review |
| title_sort | microbiome modulation in pediatric leukemia impact on graft versus host disease and treatment outcomes a narrative review |
| topic | childhood leukemia gut microbiome fecal microbiota transplant hematopoietic stem-cell transplant graft-versus-host disease |
| url | https://www.mdpi.com/2227-9067/12/2/166 |
| work_keys_str_mv | AT samuelbogdantodor microbiomemodulationinpediatricleukemiaimpactongraftversushostdiseaseandtreatmentoutcomesanarrativereview AT cristianichim microbiomemodulationinpediatricleukemiaimpactongraftversushostdiseaseandtreatmentoutcomesanarrativereview |