Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformatics
Dadiah is one of traditional food in West Sumatera. It is made from naturally fermented buffalo milk in bamboo tubes by lactic acid bacteria found naturally in the buffalo milk and bamboo tubes themselves. Lactic acid bacteria strains are the main probiotics in the food and pharmaceutical markets....
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University of Guilan
2023-07-01
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| Series: | Caspian Journal of Environmental Sciences |
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| Online Access: | https://cjes.guilan.ac.ir/article_6938_d36e387705a04dbffa69600fe9afff05.pdf |
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| author | Nadia Purnama Dewi Sandeep Poddar Dessy Abdullah Yudha Endra Pratama |
| author_facet | Nadia Purnama Dewi Sandeep Poddar Dessy Abdullah Yudha Endra Pratama |
| author_sort | Nadia Purnama Dewi |
| collection | DOAJ |
| description | Dadiah is one of traditional food in West Sumatera. It is made from naturally fermented buffalo milk in bamboo tubes by lactic acid bacteria found naturally in the buffalo milk and bamboo tubes themselves. Lactic acid bacteria strains are the main probiotics in the food and pharmaceutical markets. Probiotics are live microorganisms or components of a microbial cell that give good effect to other organisms. Probiotics have an important role in the health of the gastrointestinal tract in general. Pediococcus acidilactici is one of the lactic acid bacteria that acts as a probiotic isolated from Dadiah. Insulin is a hormone produced by pancreatic beta cells, which plays an important role in regulating blood glucose levels, so that they remain in a normal state, and its promoter regulates the rate of transcription in response to physiological regulators. In human pancreatic cells, the insulin promoter interacts with loci associated with diabetes risk and controls genes involved in insulin metabolism. Insulin promoters are tissue-specific and typically only activate in islet beta cells in adult tissues to stimulate insulin production. This study aims to determine the secondary metabolites of P. acidilactici to insulin promotor expression by looking at the canonical and isomeric SMILE (simplified molecular-input line-entry system) structures in the PubChem database. After conducting bioinformatics analysis to determine the secondary metabolites of P. acidilactici, its compound has potential as a diabetes treatment, because the QSAR results show potential as an insulin promoter (0.75). |
| format | Article |
| id | doaj-art-e97dcf3723814834a866bcf2cf0b9c92 |
| institution | DOAJ |
| issn | 1735-3033 1735-3866 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | University of Guilan |
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| series | Caspian Journal of Environmental Sciences |
| spelling | doaj-art-e97dcf3723814834a866bcf2cf0b9c922025-08-20T02:52:31ZengUniversity of GuilanCaspian Journal of Environmental Sciences1735-30331735-38662023-07-0121359560210.22124/cjes.2023.69386938Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformaticsNadia Purnama Dewi0Sandeep Poddar1Dessy Abdullah2Yudha Endra Pratama3Lincoln University College, Wisma Lincoln, No. 12-18, SS 6/12, Off Jalan Perban daran, 47301 Petaling Jaya, Selangor DE; Medical Faculty, Baiturrahmah Uni versity Padang, West Sumatera, IndonesiaDeputy Vice Chancellor of Research, Lincoln University College, MalaysiaLincoln University College, Wisma Lincoln, No. 12-18, SS 6/12, Off Jalan Perban daran, 47301 Petaling Jaya, Selangor DE; Medical Faculty, Baiturrahmah Uni versity Padang, West Sumatera, IndonesiaFaculty of Animal Science, Andalas University, Padang, 21566, IndonesiaDadiah is one of traditional food in West Sumatera. It is made from naturally fermented buffalo milk in bamboo tubes by lactic acid bacteria found naturally in the buffalo milk and bamboo tubes themselves. Lactic acid bacteria strains are the main probiotics in the food and pharmaceutical markets. Probiotics are live microorganisms or components of a microbial cell that give good effect to other organisms. Probiotics have an important role in the health of the gastrointestinal tract in general. Pediococcus acidilactici is one of the lactic acid bacteria that acts as a probiotic isolated from Dadiah. Insulin is a hormone produced by pancreatic beta cells, which plays an important role in regulating blood glucose levels, so that they remain in a normal state, and its promoter regulates the rate of transcription in response to physiological regulators. In human pancreatic cells, the insulin promoter interacts with loci associated with diabetes risk and controls genes involved in insulin metabolism. Insulin promoters are tissue-specific and typically only activate in islet beta cells in adult tissues to stimulate insulin production. This study aims to determine the secondary metabolites of P. acidilactici to insulin promotor expression by looking at the canonical and isomeric SMILE (simplified molecular-input line-entry system) structures in the PubChem database. After conducting bioinformatics analysis to determine the secondary metabolites of P. acidilactici, its compound has potential as a diabetes treatment, because the QSAR results show potential as an insulin promoter (0.75).https://cjes.guilan.ac.ir/article_6938_d36e387705a04dbffa69600fe9afff05.pdfprobioticsdadiahinsulin promotorpediococcus acidilactici |
| spellingShingle | Nadia Purnama Dewi Sandeep Poddar Dessy Abdullah Yudha Endra Pratama Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformatics Caspian Journal of Environmental Sciences probiotics dadiah insulin promotor pediococcus acidilactici |
| title | Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformatics |
| title_full | Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformatics |
| title_fullStr | Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformatics |
| title_full_unstemmed | Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformatics |
| title_short | Evaluation of Pediococcus acidilactici from Dadiah Bukitinggi (dairy food) as an insulin promotor by bioinformatics |
| title_sort | evaluation of pediococcus acidilactici from dadiah bukitinggi dairy food as an insulin promotor by bioinformatics |
| topic | probiotics dadiah insulin promotor pediococcus acidilactici |
| url | https://cjes.guilan.ac.ir/article_6938_d36e387705a04dbffa69600fe9afff05.pdf |
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