Challenges and Controversies in Human Mesenchymal Stem Cell Therapy
Stem cell therapy is being intensely investigated within the last years. Expectations are high regarding mesenchymal stem cell (MSC) treatment in translational medicine. However, many aspects concerning MSC therapy should be profoundly defined. Due to a variety of approaches that are investigated, p...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/9628536 |
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| author | Barbara Lukomska Luiza Stanaszek Ewa Zuba-Surma Pawel Legosz Sylwia Sarzynska Katarzyna Drela |
| author_facet | Barbara Lukomska Luiza Stanaszek Ewa Zuba-Surma Pawel Legosz Sylwia Sarzynska Katarzyna Drela |
| author_sort | Barbara Lukomska |
| collection | DOAJ |
| description | Stem cell therapy is being intensely investigated within the last years. Expectations are high regarding mesenchymal stem cell (MSC) treatment in translational medicine. However, many aspects concerning MSC therapy should be profoundly defined. Due to a variety of approaches that are investigated, potential effects of stem cell therapy are not transparent. On the other hand, most results of MSC administration in vivo have confirmed their safety and showed promising beneficial outcomes. However, the therapeutic effects of MSC-based treatment are still not spectacular and there is a potential risk related to MSC applications into specific cell niche that should be considered in long-term observations and follow-up outcomes. In this review, we intend to address some problems and critically discuss the complex nature of MSCs in the context of their effective and safe applications in regenerative medicine in different diseases including graft versus host disease (GvHD) and cardiac, neurological, and orthopedic disorders. |
| format | Article |
| id | doaj-art-e975c1ef324548308650c6575b42dc2e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e975c1ef324548308650c6575b42dc2e2025-02-03T06:11:33ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/96285369628536Challenges and Controversies in Human Mesenchymal Stem Cell TherapyBarbara Lukomska0Luiza Stanaszek1Ewa Zuba-Surma2Pawel Legosz3Sylwia Sarzynska4Katarzyna Drela5NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, PolandNeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, PolandDepartment of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, PolandDepartment of Orthopedics and Traumatology, 1st Faculty of Medicine, Medical University of Warsaw, Warsaw, PolandDepartment of Orthopedics and Traumatology, 1st Faculty of Medicine, Medical University of Warsaw, Warsaw, PolandNeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, PolandStem cell therapy is being intensely investigated within the last years. Expectations are high regarding mesenchymal stem cell (MSC) treatment in translational medicine. However, many aspects concerning MSC therapy should be profoundly defined. Due to a variety of approaches that are investigated, potential effects of stem cell therapy are not transparent. On the other hand, most results of MSC administration in vivo have confirmed their safety and showed promising beneficial outcomes. However, the therapeutic effects of MSC-based treatment are still not spectacular and there is a potential risk related to MSC applications into specific cell niche that should be considered in long-term observations and follow-up outcomes. In this review, we intend to address some problems and critically discuss the complex nature of MSCs in the context of their effective and safe applications in regenerative medicine in different diseases including graft versus host disease (GvHD) and cardiac, neurological, and orthopedic disorders.http://dx.doi.org/10.1155/2019/9628536 |
| spellingShingle | Barbara Lukomska Luiza Stanaszek Ewa Zuba-Surma Pawel Legosz Sylwia Sarzynska Katarzyna Drela Challenges and Controversies in Human Mesenchymal Stem Cell Therapy Stem Cells International |
| title | Challenges and Controversies in Human Mesenchymal Stem Cell Therapy |
| title_full | Challenges and Controversies in Human Mesenchymal Stem Cell Therapy |
| title_fullStr | Challenges and Controversies in Human Mesenchymal Stem Cell Therapy |
| title_full_unstemmed | Challenges and Controversies in Human Mesenchymal Stem Cell Therapy |
| title_short | Challenges and Controversies in Human Mesenchymal Stem Cell Therapy |
| title_sort | challenges and controversies in human mesenchymal stem cell therapy |
| url | http://dx.doi.org/10.1155/2019/9628536 |
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