Oxidative Stress Mediates the Dual Regulatory Effects of Bovine Uterine ECM Remodeling Through the TGF-β1/Smad3 Pathway: Molecular Mechanisms of MMPs and COL-IV Imbalances

Oxidative Stress Mediates the Dual Regulatory Effects of Bovine Uterine ECM Remodeling Through the TGF-β1/Smad3 Pathway: Molecular Mechanisms of MMPs and COL-IV Imbalances

Bovine endometritis is a common endocrine and reproductive disorder in postpartum dairy cows, closely associated with elevated systemic oxidative stress. This disease can lead to delayed uterine involution, repeated breeding failure, and significant economic losses in the dairy industry. Studies sug...

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Bibliographic Details
Main Authors: Jiamei Tan, Zongjie Wang, Mingmao Yang, Ruihang Zhang, Zhongqiang Xue, Dong Zhou, Aihua Wang, Pengfei Lin, Yaping Jin
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Animals
Subjects:
oxidative stress
bovine endometritis
TGF-β1/Smad3 signaling pathway
MMPs
ECM remodeling
Online Access:https://www.mdpi.com/2076-2615/15/13/1847
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