The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases
BackgroundTo investigate the relationship between the triglyceride and glucose (TyG) index and cognitive impairment (CI).MethodsFive authoritative databases were systematically searched for potentially relevant studies on ‘TyG index’ and ‘CI’ from inception to 27 April 2024. Two representative datab...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1496871/full |
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| author | Ying Yang Ying Yang Pai Peng Pai Peng Huadong Huang Huadong Huang Yanan Zhao Yanan Zhao Yating Li Yating Li Xiao Xu Shixie Jiang Yanrong Yang Gaofeng Pan Yanting Wen Dan Wu Shanping Chen Lei Feng Tangming Peng Jiang Wang Jiang Wang Zheng Li |
| author_facet | Ying Yang Ying Yang Pai Peng Pai Peng Huadong Huang Huadong Huang Yanan Zhao Yanan Zhao Yating Li Yating Li Xiao Xu Shixie Jiang Yanrong Yang Gaofeng Pan Yanting Wen Dan Wu Shanping Chen Lei Feng Tangming Peng Jiang Wang Jiang Wang Zheng Li |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | BackgroundTo investigate the relationship between the triglyceride and glucose (TyG) index and cognitive impairment (CI).MethodsFive authoritative databases were systematically searched for potentially relevant studies on ‘TyG index’ and ‘CI’ from inception to 27 April 2024. Two representative databases from the United Kingdom and United States were also included. We used the PICOS criteria to select available articles. All data was combined to compute Odd Ratios (ORs).Results15 studies were included in the meta-analysis (participants: 5604303). The pooled effect sizes demonstrate that individuals with a high TyG index exhibit a significantly elevated risk of CI compared to those with a low TyG index (OR = 2.16, 95%CI: 1.51; 3.08, p < 0.001). The subgroup analysis showed that inpatients with a high TyG index exhibited an increased risk of CI (OR = 4.56, 95%CI: 3.09; 6.74, p < 0.001). Furthermore, the risk of developing distinct types of CI differed significantly [CI: OR = 1.64, 95% CI: 1.29; 2.07, p < 0.001; Vascular Cognitive Impairment (VCI): OR = 5.39, 95% CI: 3.33; 8.70, p < 0.001].ConclusionA positive correlation exists between the TyG index and risk of CI, which has potential value in optimizing CI risk stratification among elderly people, especially those hospitalized.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023450336. |
| format | Article |
| id | doaj-art-e974579cd900431dbea3d7479dd9a2e3 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-e974579cd900431dbea3d7479dd9a2e32025-08-20T02:48:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-11-011510.3389/fneur.2024.14968711496871The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databasesYing Yang0Ying Yang1Pai Peng2Pai Peng3Huadong Huang4Huadong Huang5Yanan Zhao6Yanan Zhao7Yating Li8Yating Li9Xiao Xu10Shixie Jiang11Yanrong Yang12Gaofeng Pan13Yanting Wen14Dan Wu15Shanping Chen16Lei Feng17Tangming Peng18Jiang Wang19Jiang Wang20Zheng Li21Department of Neurology, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, ChinaSchool of Computer Science and Technology, Chongqing University of Postsand Telecommunications, Chongqing, ChinaSchool of Clinical Medicine, Jinggangshan University, Ji'an, Jiangxi Province, ChinaOnline Collaborative Research Center for Evidence-Based Medicine Ministry of Education, Jinggangshan University Branch, Ji'an, Jiangxi Province, ChinaSchool of Clinical Medicine, Jinggangshan University, Ji'an, Jiangxi Province, ChinaOnline Collaborative Research Center for Evidence-Based Medicine Ministry of Education, Jinggangshan University Branch, Ji'an, Jiangxi Province, ChinaOnline Collaborative Research Center for Evidence-Based Medicine Ministry of Education, Jinggangshan University Branch, Ji'an, Jiangxi Province, ChinaSchool of Basic Medicine, Jinggangshan University, Ji'an, Jiangxi Province, ChinaOnline Collaborative Research Center for Evidence-Based Medicine Ministry of Education, Jinggangshan University Branch, Ji'an, Jiangxi Province, ChinaSchool of Basic Medicine, Jinggangshan University, Ji'an, Jiangxi Province, ChinaState Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Psychiatry, University of Florida College of Medicine, Gainesville, FL, United StatesDepartment of Neurology, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, ChinaDepartment of Neurology, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, ChinaDepartment of Ultrasound Medicine, Chengdu Fifth People’s Hospital, Chengdu, Sichuan Province, ChinaSchool of Computer Science and Technology, Chongqing University of Postsand Telecommunications, Chongqing, ChinaDepartment of Geriatrics, Chengdu Fifth People’s Hospital, Chengdu, Sichuan Province, ChinaDepartment of Neurology, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, ChinaDepartment of Neurology, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, ChinaOnline Collaborative Research Center for Evidence-Based Medicine Ministry of Education, Jinggangshan University Branch, Ji'an, Jiangxi Province, ChinaSchool of Basic Medicine, Jinggangshan University, Ji'an, Jiangxi Province, ChinaDepartment of Neurology, Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, ChinaBackgroundTo investigate the relationship between the triglyceride and glucose (TyG) index and cognitive impairment (CI).MethodsFive authoritative databases were systematically searched for potentially relevant studies on ‘TyG index’ and ‘CI’ from inception to 27 April 2024. Two representative databases from the United Kingdom and United States were also included. We used the PICOS criteria to select available articles. All data was combined to compute Odd Ratios (ORs).Results15 studies were included in the meta-analysis (participants: 5604303). The pooled effect sizes demonstrate that individuals with a high TyG index exhibit a significantly elevated risk of CI compared to those with a low TyG index (OR = 2.16, 95%CI: 1.51; 3.08, p < 0.001). The subgroup analysis showed that inpatients with a high TyG index exhibited an increased risk of CI (OR = 4.56, 95%CI: 3.09; 6.74, p < 0.001). Furthermore, the risk of developing distinct types of CI differed significantly [CI: OR = 1.64, 95% CI: 1.29; 2.07, p < 0.001; Vascular Cognitive Impairment (VCI): OR = 5.39, 95% CI: 3.33; 8.70, p < 0.001].ConclusionA positive correlation exists between the TyG index and risk of CI, which has potential value in optimizing CI risk stratification among elderly people, especially those hospitalized.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023450336.https://www.frontiersin.org/articles/10.3389/fneur.2024.1496871/fullthe triglyceride and glucose (TyG) indexcognitive impairment(CI)prevalenceelderly peopleinpatientsVascular Cognitive Impairment (VCI) |
| spellingShingle | Ying Yang Ying Yang Pai Peng Pai Peng Huadong Huang Huadong Huang Yanan Zhao Yanan Zhao Yating Li Yating Li Xiao Xu Shixie Jiang Yanrong Yang Gaofeng Pan Yanting Wen Dan Wu Shanping Chen Lei Feng Tangming Peng Jiang Wang Jiang Wang Zheng Li The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases Frontiers in Neurology the triglyceride and glucose (TyG) index cognitive impairment(CI) prevalence elderly people inpatients Vascular Cognitive Impairment (VCI) |
| title | The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases |
| title_full | The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases |
| title_fullStr | The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases |
| title_full_unstemmed | The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases |
| title_short | The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases |
| title_sort | triglyceride glucose index and risk of cognitive impairment a systematic review and meta analysis with inclusion of two national databases |
| topic | the triglyceride and glucose (TyG) index cognitive impairment(CI) prevalence elderly people inpatients Vascular Cognitive Impairment (VCI) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1496871/full |
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