Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safety
The combination of immunosuppressants and chemotherapy has reshaped the treatment landscape for esophageal cancer (EC). This study aimed to evaluate the effectiveness and safety of a neoadjuvant immunochemotherapy (nICT) regimen in patients with resectable EC. A total of 99 eligible patients were i...
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-04-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | http://www.bjbms.org/ojs/index.php/bjbms/article/view/11806 |
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| author | Xiaomin Wang Bingxu Li Zhiyong Zheng Weijie Wang |
| author_facet | Xiaomin Wang Bingxu Li Zhiyong Zheng Weijie Wang |
| author_sort | Xiaomin Wang |
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The combination of immunosuppressants and chemotherapy has reshaped the treatment landscape for esophageal cancer (EC). This study aimed to evaluate the effectiveness and safety of a neoadjuvant immunochemotherapy (nICT) regimen in patients with resectable EC. A total of 99 eligible patients were included. Data on patient characteristics, nICT regimens, surgical approaches, postoperative outcomes, adverse events related to neoadjuvant therapy and surgery, overall survival (OS), and disease-free survival (DFS) were collected. OS, DFS, and safety were the primary endpoints. Cox regression analysis was used to identify prognostic factors in the overall population. Additionally, exploratory research was conducted to assess the clinical value of blood immune indicators in predicting tumor regression. Following surgery, 99.0% of patients achieved complete resection (R0). After neoadjuvant therapy, the number of patients with stage T0N0 increased, with complete or moderate responses being the most common outcomes according to AJCC/CAP-TRG evaluations (64.7%). The 1-year OS and DFS rates were 91.6% and 49.3%, respectively. Grade ≥3 adverse events related to neoadjuvant therapy occurred in 21.2% of patients, with gastrointestinal reactions being the most frequent (16 cases, 16.2%). No treatment-related deaths were reported. Grade ≥3 surgery-related adverse events occurred in 10.1% of patients, with anastomotic leakage being the most common (6 cases, 6.1%). Several factors were associated with significantly improved OS, including chemotherapy regimens combining paclitaxel with platinum, surgical approaches using laparoscopy or thoracotomy (left or right), an interval of ≤34 days between the last treatment and surgery, and the absence of positive lymph node detection. Higher cT staging was significantly associated with worse DFS. Blood immune markers such as the neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) were found to predict tumor regression in EC patients. In summary, nICT demonstrated favorable effectiveness and safety in resectable EC. The choice of platinum-based chemotherapy agents, rather than the type of immunosuppressant, was associated with prognosis. Moreover, a shorter interval (≤ 34 days) between the final nICT administration and surgery was linked to improved outcomes.
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| format | Article |
| id | doaj-art-e9707beaf11047d7919979f31d1b2936 |
| institution | OA Journals |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
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| series | Biomolecules & Biomedicine |
| spelling | doaj-art-e9707beaf11047d7919979f31d1b29362025-08-20T01:53:16ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-04-0110.17305/bb.2025.11806Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safetyXiaomin Wang0Bingxu Li1Zhiyong Zheng2Weijie Wang3Department 1st of Radiation Oncology, Anyang Tumor Hospital, Anyang City, Henan Province, ChinaDepartment 1st of Radiation Oncology, Anyang Tumor Hospital, Anyang City, Henan Province, ChinaDepartment 1st of Radiation Oncology, Anyang Tumor Hospital, Anyang City, Henan Province, ChinaDepartment Thoracic Surgery, Anyang Tumor Hospital, Anyang City, Henan Province, China The combination of immunosuppressants and chemotherapy has reshaped the treatment landscape for esophageal cancer (EC). This study aimed to evaluate the effectiveness and safety of a neoadjuvant immunochemotherapy (nICT) regimen in patients with resectable EC. A total of 99 eligible patients were included. Data on patient characteristics, nICT regimens, surgical approaches, postoperative outcomes, adverse events related to neoadjuvant therapy and surgery, overall survival (OS), and disease-free survival (DFS) were collected. OS, DFS, and safety were the primary endpoints. Cox regression analysis was used to identify prognostic factors in the overall population. Additionally, exploratory research was conducted to assess the clinical value of blood immune indicators in predicting tumor regression. Following surgery, 99.0% of patients achieved complete resection (R0). After neoadjuvant therapy, the number of patients with stage T0N0 increased, with complete or moderate responses being the most common outcomes according to AJCC/CAP-TRG evaluations (64.7%). The 1-year OS and DFS rates were 91.6% and 49.3%, respectively. Grade ≥3 adverse events related to neoadjuvant therapy occurred in 21.2% of patients, with gastrointestinal reactions being the most frequent (16 cases, 16.2%). No treatment-related deaths were reported. Grade ≥3 surgery-related adverse events occurred in 10.1% of patients, with anastomotic leakage being the most common (6 cases, 6.1%). Several factors were associated with significantly improved OS, including chemotherapy regimens combining paclitaxel with platinum, surgical approaches using laparoscopy or thoracotomy (left or right), an interval of ≤34 days between the last treatment and surgery, and the absence of positive lymph node detection. Higher cT staging was significantly associated with worse DFS. Blood immune markers such as the neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) were found to predict tumor regression in EC patients. In summary, nICT demonstrated favorable effectiveness and safety in resectable EC. The choice of platinum-based chemotherapy agents, rather than the type of immunosuppressant, was associated with prognosis. Moreover, a shorter interval (≤ 34 days) between the final nICT administration and surgery was linked to improved outcomes. http://www.bjbms.org/ojs/index.php/bjbms/article/view/11806Immunotherapychemotherapyneoadjuvant therapyesophageal cancerECneoadjuvant immunochemotherapy |
| spellingShingle | Xiaomin Wang Bingxu Li Zhiyong Zheng Weijie Wang Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safety Biomolecules & Biomedicine Immunotherapy chemotherapy neoadjuvant therapy esophageal cancer EC neoadjuvant immunochemotherapy |
| title | Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safety |
| title_full | Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safety |
| title_fullStr | Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safety |
| title_full_unstemmed | Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safety |
| title_short | Neoadjuvant immunochemotherapy for resectable esophageal cancer: A study on efficacy and safety |
| title_sort | neoadjuvant immunochemotherapy for resectable esophageal cancer a study on efficacy and safety |
| topic | Immunotherapy chemotherapy neoadjuvant therapy esophageal cancer EC neoadjuvant immunochemotherapy |
| url | http://www.bjbms.org/ojs/index.php/bjbms/article/view/11806 |
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