Efficacy and Safety of Cisatracurium in Electroconvulsive Therapy: A Randomized, Single-blind, Clinical Trial
Background: Electroconvulsive therapy (ECT) is widely accepted as a safe and effective treatment in psychiatric patients. Although succinylcholine is the choice of muscle relaxant in this process, its adverse effects and contraindications must be considered. Objectives: This study investigated the e...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Guilan University of Medical Sciences
2024-10-01
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| Series: | Caspian Journal of Neurological Sciences |
| Subjects: | |
| Online Access: | http://cjns.gums.ac.ir/article-1-730-en.pdf |
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| Summary: | Background: Electroconvulsive therapy (ECT) is widely accepted as a safe and effective treatment in psychiatric patients. Although succinylcholine is the choice of muscle relaxant in this process, its adverse effects and contraindications must be considered.
Objectives: This study investigated the efficacy of cisatracurium as an alternative in ECT patients.
Materials & Methods: This single-blind clinical trial was performed in an academic hospital in Northern Iran from July 2023 to March 2024. A total of 62 eligible ECT patients were enrolled in the survey and randomly divided into succinylcholine (0.5 mg/kg) and cisatracurium (0.1 mg/kg) groups. Seizure duration, mean arterial pressure, heart rate, the time to return to spontaneous breathing, and recovery time were recorded and compared between the two groups.
Results: No significant difference was observed between the two groups regarding seizure duration and hemodynamic parameters (P>0.05). However, the time to return to spontaneous breathing (P=0.0001) and recovery time (P=0.0001) were significantly longer in the cisatracurium group. None of the patients was affected by serious adverse effects.
Conclusion: Cisatracurium is a safe alternative to succinylcholine and can be administrated during ECT. |
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| ISSN: | 2423-4818 |