Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance
Type 2 diabetes mellitus and Parkinson’s disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden. Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-11-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-23-01910 |
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| author | Theodora Ntetsika Sergiu-Bogdan Catrina Ioanna Markaki |
| author_facet | Theodora Ntetsika Sergiu-Bogdan Catrina Ioanna Markaki |
| author_sort | Theodora Ntetsika |
| collection | DOAJ |
| description | Type 2 diabetes mellitus and Parkinson’s disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden. Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms. Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson’s disease through the dysregulation of several pathological processes. The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson’s disease, with emphasis on brain insulin resistance, is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed. |
| format | Article |
| id | doaj-art-e96bb508cfa941558d426c1360a90b88 |
| institution | Kabale University |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-e96bb508cfa941558d426c1360a90b882025-01-07T09:49:28ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582025-11-0120113113312310.4103/NRR.NRR-D-23-01910Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistanceTheodora NtetsikaSergiu-Bogdan CatrinaIoanna MarkakiType 2 diabetes mellitus and Parkinson’s disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden. Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms. Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson’s disease through the dysregulation of several pathological processes. The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson’s disease, with emphasis on brain insulin resistance, is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.https://journals.lww.com/10.4103/NRR.NRR-D-23-01910brain insulin resistancebrain insulin signalingdiabetes type 2glp-1 receptor agonistsglp-1 signalinginsulin resistanceinsulin signalingneurodegenerationparkinson’s diseasetargeted therapy |
| spellingShingle | Theodora Ntetsika Sergiu-Bogdan Catrina Ioanna Markaki Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance Neural Regeneration Research brain insulin resistance brain insulin signaling diabetes type 2 glp-1 receptor agonists glp-1 signaling insulin resistance insulin signaling neurodegeneration parkinson’s disease targeted therapy |
| title | Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance |
| title_full | Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance |
| title_fullStr | Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance |
| title_full_unstemmed | Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance |
| title_short | Understanding the link between type 2 diabetes mellitus and Parkinson’s disease: role of brain insulin resistance |
| title_sort | understanding the link between type 2 diabetes mellitus and parkinson s disease role of brain insulin resistance |
| topic | brain insulin resistance brain insulin signaling diabetes type 2 glp-1 receptor agonists glp-1 signaling insulin resistance insulin signaling neurodegeneration parkinson’s disease targeted therapy |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-23-01910 |
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