Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke
Objective. This study is aimed at investigating the association between the twenty-four-hour ambulatory blood pressure variability monitoring (ABPM) and cerebral small vessel disease (cSVD) burden in acute ischemic stroke (AIS) patients. Methods. 115 AIS patients with demographics, vascular risk fac...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2022/3769577 |
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| author | Jun Shen Lu Yang Ziwei Xu Wenshi Wei |
| author_facet | Jun Shen Lu Yang Ziwei Xu Wenshi Wei |
| author_sort | Jun Shen |
| collection | DOAJ |
| description | Objective. This study is aimed at investigating the association between the twenty-four-hour ambulatory blood pressure variability monitoring (ABPM) and cerebral small vessel disease (cSVD) burden in acute ischemic stroke (AIS) patients. Methods. 115 AIS patients with demographics, vascular risk factors, 24 h ABPM, and brain magnetic resonance imaging (MRI) were retrospectively enrolled. 3.0 T MRI was used to assess cSVD burden by combining four MRI markers including white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), perivascular spaces (PVS), and lacunes. Correlation analysis was conducted to detect whether ABPM was associated with cSVD burden in AIS patients. Results. 115 AIS patients with mean age 68.77±10.26 years and 75.7% male were enrolled in this study. 112 AIS patients (97.4%) had at least one cSVD marker. Spearman correlation analysis indicated that hypertension was positively correlated with cSVD burden (ρ=0.21, P=0.07). High-density lipoprotein (HDL) was negatively correlated with cSVD burden (ρ=−0.21, P=0.02). Blood pressure variability such as 24 h mean SBP (ρ=0.23, P=0.01), day mean SBP (ρ=0.23, P=0.01), and night mean SBP (ρ=0.20, P=0.04) was positively correlated with higher cSVD burden. Ordinal logistic regression analysis demonstrated that higher 24 h SBP SD and day mean SBP were independent risk factors for cSVD after controlling for other confounders. Conclusions. Higher BPV was significantly related to total cSVD burden in AIS patients. 24 h SBP SD and day mean SBP were independent risk factors for cSVD burden in AIS patients but not DBP or DBP variability. |
| format | Article |
| id | doaj-art-e9688fb8bf41433f877573c3efbe9cad |
| institution | DOAJ |
| issn | 1875-8584 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-e9688fb8bf41433f877573c3efbe9cad2025-08-20T03:21:08ZengWileyBehavioural Neurology1875-85842022-01-01202210.1155/2022/3769577Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic StrokeJun Shen0Lu Yang1Ziwei Xu2Wenshi Wei3Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyObjective. This study is aimed at investigating the association between the twenty-four-hour ambulatory blood pressure variability monitoring (ABPM) and cerebral small vessel disease (cSVD) burden in acute ischemic stroke (AIS) patients. Methods. 115 AIS patients with demographics, vascular risk factors, 24 h ABPM, and brain magnetic resonance imaging (MRI) were retrospectively enrolled. 3.0 T MRI was used to assess cSVD burden by combining four MRI markers including white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), perivascular spaces (PVS), and lacunes. Correlation analysis was conducted to detect whether ABPM was associated with cSVD burden in AIS patients. Results. 115 AIS patients with mean age 68.77±10.26 years and 75.7% male were enrolled in this study. 112 AIS patients (97.4%) had at least one cSVD marker. Spearman correlation analysis indicated that hypertension was positively correlated with cSVD burden (ρ=0.21, P=0.07). High-density lipoprotein (HDL) was negatively correlated with cSVD burden (ρ=−0.21, P=0.02). Blood pressure variability such as 24 h mean SBP (ρ=0.23, P=0.01), day mean SBP (ρ=0.23, P=0.01), and night mean SBP (ρ=0.20, P=0.04) was positively correlated with higher cSVD burden. Ordinal logistic regression analysis demonstrated that higher 24 h SBP SD and day mean SBP were independent risk factors for cSVD after controlling for other confounders. Conclusions. Higher BPV was significantly related to total cSVD burden in AIS patients. 24 h SBP SD and day mean SBP were independent risk factors for cSVD burden in AIS patients but not DBP or DBP variability.http://dx.doi.org/10.1155/2022/3769577 |
| spellingShingle | Jun Shen Lu Yang Ziwei Xu Wenshi Wei Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke Behavioural Neurology |
| title | Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke |
| title_full | Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke |
| title_fullStr | Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke |
| title_full_unstemmed | Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke |
| title_short | Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke |
| title_sort | association between twenty four hour ambulatory blood pressure variability and cerebral small vessel disease burden in acute ischemic stroke |
| url | http://dx.doi.org/10.1155/2022/3769577 |
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