Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders
Abstract Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent studies have revealed that certain H...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-04084-6 |
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| author | Yalu Chen Jianqiao Shentu Hanqi Lou Yongming Xia Yinyan Jiang Shiwei Duan |
| author_facet | Yalu Chen Jianqiao Shentu Hanqi Lou Yongming Xia Yinyan Jiang Shiwei Duan |
| author_sort | Yalu Chen |
| collection | DOAJ |
| description | Abstract Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent studies have revealed that certain HSCs exhibit a bias toward platelet differentiation, termed platelet-biased HSCs (P-HSCs). This lineage bias, particularly pronounced with aging, can lead to imbalances in post-transplant blood recovery, negatively affecting patient outcomes. Research by Claus Nerlov’s team has provided key insights into the heterogeneity of HSCs, focusing on the age-related expansion of P-HSCs. Using advanced techniques such as single-cell RNA sequencing and molecular barcoding, their work highlights the evolutionary conservation of platelet bias in HSCs across species. This work delves into these findings, discussing their clinical implications for bone marrow transplantation, aging-related blood disorders, and potential therapeutic strategies. Moreover, we address limitations in current methodologies and propose future directions for research to optimize HSC-based therapies and improve clinical outcomes in hematological diseases. |
| format | Article |
| id | doaj-art-e966ce3961254bcfbfa3ff61766c88c7 |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-e966ce3961254bcfbfa3ff61766c88c72024-12-08T12:20:46ZengBMCStem Cell Research & Therapy1757-65122024-12-011511410.1186/s13287-024-04084-6Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disordersYalu Chen0Jianqiao Shentu1Hanqi Lou2Yongming Xia3Yinyan Jiang4Shiwei Duan5Department of Hematology, Yuyao People’s Hospital of Zhejiang Province, The Affiliated Yangming Hospital of Ningbo UniversityDepartment of Clinical Medicine, Hangzhou City UniversityDepartment of Clinical Medicine, Hangzhou City UniversityDepartment of Hematology, Yuyao People’s Hospital of Zhejiang Province, The Affiliated Yangming Hospital of Ningbo UniversityDepartment of Hematology, Yuyao People’s Hospital of Zhejiang Province, The Affiliated Yangming Hospital of Ningbo UniversityDepartment of Clinical Medicine, Hangzhou City UniversityAbstract Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent studies have revealed that certain HSCs exhibit a bias toward platelet differentiation, termed platelet-biased HSCs (P-HSCs). This lineage bias, particularly pronounced with aging, can lead to imbalances in post-transplant blood recovery, negatively affecting patient outcomes. Research by Claus Nerlov’s team has provided key insights into the heterogeneity of HSCs, focusing on the age-related expansion of P-HSCs. Using advanced techniques such as single-cell RNA sequencing and molecular barcoding, their work highlights the evolutionary conservation of platelet bias in HSCs across species. This work delves into these findings, discussing their clinical implications for bone marrow transplantation, aging-related blood disorders, and potential therapeutic strategies. Moreover, we address limitations in current methodologies and propose future directions for research to optimize HSC-based therapies and improve clinical outcomes in hematological diseases.https://doi.org/10.1186/s13287-024-04084-6Lineage biasPlatelet-biased HSCsBone marrow transplantationBlood disordersTherapeutic strategies |
| spellingShingle | Yalu Chen Jianqiao Shentu Hanqi Lou Yongming Xia Yinyan Jiang Shiwei Duan Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders Stem Cell Research & Therapy Lineage bias Platelet-biased HSCs Bone marrow transplantation Blood disorders Therapeutic strategies |
| title | Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders |
| title_full | Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders |
| title_fullStr | Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders |
| title_full_unstemmed | Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders |
| title_short | Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders |
| title_sort | hematopoietic stem cell heterogeneity and age related platelet bias implications for bone marrow transplantation and blood disorders |
| topic | Lineage bias Platelet-biased HSCs Bone marrow transplantation Blood disorders Therapeutic strategies |
| url | https://doi.org/10.1186/s13287-024-04084-6 |
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