Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancer
Introduction. Breast cancer, which occurs in young women, is more often classified as a biologically aggressive subtype (HER2+ and triple negative) compared with postmenopausal patients. At the same time, it is important to know whether age, in itself, determines a less favorable outcome of the dise...
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2025-05-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/1344 |
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| author | N. B. Bekkeldieva V. F. Semiglazov P. V. Krivorotko V. V. Mortada A. V. Komyahov K. Yu. Zernov S. S. Yereshchenko T. T. Tabagua R. S. Pesotskiy K. S. Nikolaev Ya. I. Bondarchuk N. S. Amirov D. A. Enaldieva D. G. Ulrikh V. E. Levchenko T. Yu. Semiglazova |
| author_facet | N. B. Bekkeldieva V. F. Semiglazov P. V. Krivorotko V. V. Mortada A. V. Komyahov K. Yu. Zernov S. S. Yereshchenko T. T. Tabagua R. S. Pesotskiy K. S. Nikolaev Ya. I. Bondarchuk N. S. Amirov D. A. Enaldieva D. G. Ulrikh V. E. Levchenko T. Yu. Semiglazova |
| author_sort | N. B. Bekkeldieva |
| collection | DOAJ |
| description | Introduction. Breast cancer, which occurs in young women, is more often classified as a biologically aggressive subtype (HER2+ and triple negative) compared with postmenopausal patients. At the same time, it is important to know whether age, in itself, determines a less favorable outcome of the disease in young patients.Aim. To evaluate overall and recurrence-free survival rates in premenopausal and postmenopausal patients who underwent various levels of surgery and received neoadjuvant and adjuvant systemic therapy.Materials and methods. Of the 3,450 analyzed patients, the final analysis included 265 patients with breast cancer (clinical stage T1–3N0–1M0) who received treatment between 2011 and 2019, who were divided into 2 groups depending on age category, biological tumor subtype, types of neoadjuvant and adjuvant treatment.Results. Of 265 included patients, 162 (61.1 %) were premenopausal women, 103 (38.9 %) were postmenopausal women. The median follow-up was 5 years. The 5-year overall survival was 96.8 % (95 % confidence interval (CI) 92.6–98.7) in premenopausal patients and 95.1 % (95 % CI 88.5–97.9) in postmenopausal patients. The differences in overall survival estimated using the likelihood ratio test were not statistically significant (p = 0.927). The 5-year recurrencefree survival rate was 77.6 % (95 % CI 70.3–83.3) in premenopausal patients and 84.2 % (95 % CI 75.6–90.0) in postmenopausal patients. The differences in disease-free survival estimated using the likelihood ratio test were not statistically significant (p = 0.253).Conclusion. When comparing patients with early breast cancer, overall and relapse-free survival did not depend on menopausal status. It is necessary to conduct randomized trials to determine the effectiveness of drug therapy. |
| format | Article |
| id | doaj-art-e960ab83aa1f4fbd806e96a3d05ee5f6 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2025-05-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-e960ab83aa1f4fbd806e96a3d05ee5f62025-08-20T03:38:26ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272025-05-01211142110.17650/1994-4098-2025-21-1-14-21891Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancerN. B. Bekkeldieva0V. F. Semiglazov1P. V. Krivorotko2V. V. Mortada3A. V. Komyahov4K. Yu. Zernov5S. S. Yereshchenko6T. T. Tabagua7R. S. Pesotskiy8K. S. Nikolaev9Ya. I. Bondarchuk10N. S. Amirov11D. A. Enaldieva12D. G. Ulrikh13V. E. Levchenko14T. Yu. Semiglazova15N. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN. N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaIntroduction. Breast cancer, which occurs in young women, is more often classified as a biologically aggressive subtype (HER2+ and triple negative) compared with postmenopausal patients. At the same time, it is important to know whether age, in itself, determines a less favorable outcome of the disease in young patients.Aim. To evaluate overall and recurrence-free survival rates in premenopausal and postmenopausal patients who underwent various levels of surgery and received neoadjuvant and adjuvant systemic therapy.Materials and methods. Of the 3,450 analyzed patients, the final analysis included 265 patients with breast cancer (clinical stage T1–3N0–1M0) who received treatment between 2011 and 2019, who were divided into 2 groups depending on age category, biological tumor subtype, types of neoadjuvant and adjuvant treatment.Results. Of 265 included patients, 162 (61.1 %) were premenopausal women, 103 (38.9 %) were postmenopausal women. The median follow-up was 5 years. The 5-year overall survival was 96.8 % (95 % confidence interval (CI) 92.6–98.7) in premenopausal patients and 95.1 % (95 % CI 88.5–97.9) in postmenopausal patients. The differences in overall survival estimated using the likelihood ratio test were not statistically significant (p = 0.927). The 5-year recurrencefree survival rate was 77.6 % (95 % CI 70.3–83.3) in premenopausal patients and 84.2 % (95 % CI 75.6–90.0) in postmenopausal patients. The differences in disease-free survival estimated using the likelihood ratio test were not statistically significant (p = 0.253).Conclusion. When comparing patients with early breast cancer, overall and relapse-free survival did not depend on menopausal status. It is necessary to conduct randomized trials to determine the effectiveness of drug therapy.https://ojrs.abvpress.ru/ojrs/article/view/1344breast cancersystemic therapypremenopausal and postmenopausal patientsoverall survivalreсurrence-free survival |
| spellingShingle | N. B. Bekkeldieva V. F. Semiglazov P. V. Krivorotko V. V. Mortada A. V. Komyahov K. Yu. Zernov S. S. Yereshchenko T. T. Tabagua R. S. Pesotskiy K. S. Nikolaev Ya. I. Bondarchuk N. S. Amirov D. A. Enaldieva D. G. Ulrikh V. E. Levchenko T. Yu. Semiglazova Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancer Опухоли женской репродуктивной системы breast cancer systemic therapy premenopausal and postmenopausal patients overall survival reсurrence-free survival |
| title | Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancer |
| title_full | Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancer |
| title_fullStr | Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancer |
| title_full_unstemmed | Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancer |
| title_short | Comparative analysis of survival rates of pre- and postmenopausal patients with early breast cancer |
| title_sort | comparative analysis of survival rates of pre and postmenopausal patients with early breast cancer |
| topic | breast cancer systemic therapy premenopausal and postmenopausal patients overall survival reсurrence-free survival |
| url | https://ojrs.abvpress.ru/ojrs/article/view/1344 |
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