A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic Telangiectasia

This case unveils a rare genetic intersection in which autosomal-dominant hereditary hemorrhagic telangiectasia (HHT) and Turner syndrome coexist in a 53-year-old woman. Clinical signs and symptoms included abdominal pain, arteriovenous malformations, and hormonal irregularities. Diagnostic testing...

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Main Authors: Diego Mateo Cornejo Gonzalez, Imran Naeem Aziz, Shreeya Atul Sawant, Reem Yousef Darwish, Joseph Guan
Format: Article
Language:English
Published: American College of Physicians 2025-01-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2024.0746
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author Diego Mateo Cornejo Gonzalez
Imran Naeem Aziz
Shreeya Atul Sawant
Reem Yousef Darwish
Joseph Guan
author_facet Diego Mateo Cornejo Gonzalez
Imran Naeem Aziz
Shreeya Atul Sawant
Reem Yousef Darwish
Joseph Guan
author_sort Diego Mateo Cornejo Gonzalez
collection DOAJ
description This case unveils a rare genetic intersection in which autosomal-dominant hereditary hemorrhagic telangiectasia (HHT) and Turner syndrome coexist in a 53-year-old woman. Clinical signs and symptoms included abdominal pain, arteriovenous malformations, and hormonal irregularities. Diagnostic testing revealed Mosaic Turner syndrome and an ENG gene mutation linked to HHT—challenging conventional understanding and prompting exploration of possible shared pathophysiologic mechanisms. The case underscores the necessity of thorough genetic evaluations for patients with overlapping symptoms, offering insights into genetic interactions and personalized treatment approaches.
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publisher American College of Physicians
record_format Article
series Annals of Internal Medicine: Clinical Cases
spelling doaj-art-e95f8f70ce5e4c8abd0ddd4a640460502025-08-20T02:12:57ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-01-014110.7326/aimcc.2024.0746A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic TelangiectasiaDiego Mateo Cornejo Gonzalez0Imran Naeem Aziz1Shreeya Atul Sawant2Reem Yousef Darwish3Joseph Guan41John H. Stroger Hospital of Cook County, Department of Internal Medicine, Chicago, Illinois1John H. Stroger Hospital of Cook County, Department of Internal Medicine, Chicago, Illinois2Midwestern University, Chicago College of Osteopathic Medicine, Downers Grove, Illinois2Midwestern University, Chicago College of Osteopathic Medicine, Downers Grove, Illinois1John H. Stroger Hospital of Cook County, Department of Internal Medicine, Chicago, IllinoisThis case unveils a rare genetic intersection in which autosomal-dominant hereditary hemorrhagic telangiectasia (HHT) and Turner syndrome coexist in a 53-year-old woman. Clinical signs and symptoms included abdominal pain, arteriovenous malformations, and hormonal irregularities. Diagnostic testing revealed Mosaic Turner syndrome and an ENG gene mutation linked to HHT—challenging conventional understanding and prompting exploration of possible shared pathophysiologic mechanisms. The case underscores the necessity of thorough genetic evaluations for patients with overlapping symptoms, offering insights into genetic interactions and personalized treatment approaches.https://www.acpjournals.org/doi/10.7326/aimcc.2024.0746
spellingShingle Diego Mateo Cornejo Gonzalez
Imran Naeem Aziz
Shreeya Atul Sawant
Reem Yousef Darwish
Joseph Guan
A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic Telangiectasia
Annals of Internal Medicine: Clinical Cases
title A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic Telangiectasia
title_full A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic Telangiectasia
title_fullStr A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic Telangiectasia
title_full_unstemmed A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic Telangiectasia
title_short A Rare Intersection: Mosaic Turner Syndrome and Hereditary Hemorrhagic Telangiectasia
title_sort rare intersection mosaic turner syndrome and hereditary hemorrhagic telangiectasia
url https://www.acpjournals.org/doi/10.7326/aimcc.2024.0746
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