Common genetic variation and the control of HIV-1 in humans.
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We...
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| Language: | English |
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Public Library of Science (PLoS)
2009-12-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000791&type=printable |
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| author | Jacques Fellay Dongliang Ge Kevin V Shianna Sara Colombo Bruno Ledergerber Elizabeth T Cirulli Thomas J Urban Kunlin Zhang Curtis E Gumbs Jason P Smith Antonella Castagna Alessandro Cozzi-Lepri Andrea De Luca Philippa Easterbrook Huldrych F Günthard Simon Mallal Cristina Mussini Judith Dalmau Javier Martinez-Picado José M Miro Niels Obel Steven M Wolinsky Jeremy J Martinson Roger Detels Joseph B Margolick Lisa P Jacobson Patrick Descombes Stylianos E Antonarakis Jacques S Beckmann Stephen J O'Brien Norman L Letvin Andrew J McMichael Barton F Haynes Mary Carrington Sheng Feng Amalio Telenti David B Goldstein NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) |
| author_facet | Jacques Fellay Dongliang Ge Kevin V Shianna Sara Colombo Bruno Ledergerber Elizabeth T Cirulli Thomas J Urban Kunlin Zhang Curtis E Gumbs Jason P Smith Antonella Castagna Alessandro Cozzi-Lepri Andrea De Luca Philippa Easterbrook Huldrych F Günthard Simon Mallal Cristina Mussini Judith Dalmau Javier Martinez-Picado José M Miro Niels Obel Steven M Wolinsky Jeremy J Martinson Roger Detels Joseph B Margolick Lisa P Jacobson Patrick Descombes Stylianos E Antonarakis Jacques S Beckmann Stephen J O'Brien Norman L Letvin Andrew J McMichael Barton F Haynes Mary Carrington Sheng Feng Amalio Telenti David B Goldstein NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) |
| author_sort | Jacques Fellay |
| collection | DOAJ |
| description | To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians. |
| format | Article |
| id | doaj-art-e95ca120fa8643faa43ff375c73b9936 |
| institution | DOAJ |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2009-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-e95ca120fa8643faa43ff375c73b99362025-08-20T03:19:53ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042009-12-01512e100079110.1371/journal.pgen.1000791Common genetic variation and the control of HIV-1 in humans.Jacques FellayDongliang GeKevin V ShiannaSara ColomboBruno LedergerberElizabeth T CirulliThomas J UrbanKunlin ZhangCurtis E GumbsJason P SmithAntonella CastagnaAlessandro Cozzi-LepriAndrea De LucaPhilippa EasterbrookHuldrych F GünthardSimon MallalCristina MussiniJudith DalmauJavier Martinez-PicadoJosé M MiroNiels ObelSteven M WolinskyJeremy J MartinsonRoger DetelsJoseph B MargolickLisa P JacobsonPatrick DescombesStylianos E AntonarakisJacques S BeckmannStephen J O'BrienNorman L LetvinAndrew J McMichaelBarton F HaynesMary CarringtonSheng FengAmalio TelentiDavid B GoldsteinNIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000791&type=printable |
| spellingShingle | Jacques Fellay Dongliang Ge Kevin V Shianna Sara Colombo Bruno Ledergerber Elizabeth T Cirulli Thomas J Urban Kunlin Zhang Curtis E Gumbs Jason P Smith Antonella Castagna Alessandro Cozzi-Lepri Andrea De Luca Philippa Easterbrook Huldrych F Günthard Simon Mallal Cristina Mussini Judith Dalmau Javier Martinez-Picado José M Miro Niels Obel Steven M Wolinsky Jeremy J Martinson Roger Detels Joseph B Margolick Lisa P Jacobson Patrick Descombes Stylianos E Antonarakis Jacques S Beckmann Stephen J O'Brien Norman L Letvin Andrew J McMichael Barton F Haynes Mary Carrington Sheng Feng Amalio Telenti David B Goldstein NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) Common genetic variation and the control of HIV-1 in humans. PLoS Genetics |
| title | Common genetic variation and the control of HIV-1 in humans. |
| title_full | Common genetic variation and the control of HIV-1 in humans. |
| title_fullStr | Common genetic variation and the control of HIV-1 in humans. |
| title_full_unstemmed | Common genetic variation and the control of HIV-1 in humans. |
| title_short | Common genetic variation and the control of HIV-1 in humans. |
| title_sort | common genetic variation and the control of hiv 1 in humans |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000791&type=printable |
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