Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and Prospects
Liver cirrhosis is the advanced stage of liver disease accounting for high morbidity and mortality rates worldwide. Liver transplantation for liver cirrhosis has several limitations, rendering stem cell transplantation as a potential therapy. Clinical trials of stem cell applications for liver cirrh...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2022-01-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | http://www.actamedindones.org/index.php/ijim/article/view/1147 |
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| author | Prenali Dwisthi Sattwika Fahmi Indrarti Putut Bayupurnama |
| author_facet | Prenali Dwisthi Sattwika Fahmi Indrarti Putut Bayupurnama |
| author_sort | Prenali Dwisthi Sattwika |
| collection | DOAJ |
| description | Liver cirrhosis is the advanced stage of liver disease accounting for high morbidity and mortality rates worldwide. Liver transplantation for liver cirrhosis has several limitations, rendering stem cell transplantation as a potential therapy. Clinical trials of stem cell applications for liver cirrhosis are being established using various types of stem cells. This review will provide a current report of the achievements, limitations, and future directions of stem cell transplantation. Current progress of clinical trials is valuable in defining the best type of stem cells, mode of delivery, the number and frequency of cells to be injected, and determining potential candidates for cell therapy. Some of the encountered pitfalls are the limited homing and differentiation potential of stem cells, the use of non-xenofree culture system, and the risk for tumorigenesis in certain types of stem cells. The prospective developments of liver stem cell transplantation are the generation of genetically modified stem cells and the formation of liver organoids for treating liver cirrhosis.
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| format | Article |
| id | doaj-art-e95bb375cf4345039433416bc4b01ee0 |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-e95bb375cf4345039433416bc4b01ee02025-08-20T03:11:36ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-01-01534Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and ProspectsPrenali Dwisthi Sattwika0Fahmi Indrarti1Putut Bayupurnama2Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, IndonesiaDivision of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, IndonesiaDivision of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, IndonesiaLiver cirrhosis is the advanced stage of liver disease accounting for high morbidity and mortality rates worldwide. Liver transplantation for liver cirrhosis has several limitations, rendering stem cell transplantation as a potential therapy. Clinical trials of stem cell applications for liver cirrhosis are being established using various types of stem cells. This review will provide a current report of the achievements, limitations, and future directions of stem cell transplantation. Current progress of clinical trials is valuable in defining the best type of stem cells, mode of delivery, the number and frequency of cells to be injected, and determining potential candidates for cell therapy. Some of the encountered pitfalls are the limited homing and differentiation potential of stem cells, the use of non-xenofree culture system, and the risk for tumorigenesis in certain types of stem cells. The prospective developments of liver stem cell transplantation are the generation of genetically modified stem cells and the formation of liver organoids for treating liver cirrhosis. http://www.actamedindones.org/index.php/ijim/article/view/1147stem cellsliver cirrhosisregenerative medicine |
| spellingShingle | Prenali Dwisthi Sattwika Fahmi Indrarti Putut Bayupurnama Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and Prospects Acta Medica Indonesiana stem cells liver cirrhosis regenerative medicine |
| title | Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and Prospects |
| title_full | Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and Prospects |
| title_fullStr | Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and Prospects |
| title_full_unstemmed | Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and Prospects |
| title_short | Clinical Application of Stem Cell Therapy for Liver Cirrhosis: Progress, Pitfalls, and Prospects |
| title_sort | clinical application of stem cell therapy for liver cirrhosis progress pitfalls and prospects |
| topic | stem cells liver cirrhosis regenerative medicine |
| url | http://www.actamedindones.org/index.php/ijim/article/view/1147 |
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