Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive review

Mycobacterium xenopi, a nontuberculous mycobacterium (NTM), presents a significant diagnostic challenge in clinical practice, particularly in immunocompromised individuals. We report a case of M. xenopi infection in a liver transplant recipient on immunosuppressive medication. A 67-year-old male pre...

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Main Authors: Julie Lee, Kara Asbury, Rhea Ram
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Clinical Infection in Practice
Online Access:http://www.sciencedirect.com/science/article/pii/S259017022400044X
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author Julie Lee
Kara Asbury
Rhea Ram
author_facet Julie Lee
Kara Asbury
Rhea Ram
author_sort Julie Lee
collection DOAJ
description Mycobacterium xenopi, a nontuberculous mycobacterium (NTM), presents a significant diagnostic challenge in clinical practice, particularly in immunocompromised individuals. We report a case of M. xenopi infection in a liver transplant recipient on immunosuppressive medication. A 67-year-old male presented with chronic cough, anemia, and significant weight loss. Imaging studies revealed extensive pulmonary involvement with cavitations. More definitively, an acid-fast bacilli (AFB) bronchoalveolar lavage culture as well as an acid-fast bacilli (AFB) sputum culture confirmed M. xenopi infection. Treatment initiation with multiple antimicrobial agents was guided by susceptibility testing and published recommendations by the Infectious Disease Society of America and the American Thoracic Society guidelines from 2020 (Kurz, et al., 2020). This case emphasizes the importance of considering non-tubercular bacterial infections, particularly M. xenopi, in the differential diagnosis of respiratory symptoms in immunocompromised hosts. In addition to the case report, this paper provides a comprehensive review of the epidemiology, risk factors, clinical manifestations, diagnostic challenges, and treatment strategies for M. xenopi infections.
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spelling doaj-art-e95ad31a2ca44d5ca9c119c0baab8aff2025-08-20T02:50:27ZengElsevierClinical Infection in Practice2590-17022024-11-012410038410.1016/j.clinpr.2024.100384Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive reviewJulie Lee0Kara Asbury1Rhea Ram2Corresponding author.; HonorHealth Scottsdale Thompson Peak Medical Center, 7400 E Thompson Peak Pkwy, Scottsdale, AZ 85255, United StatesHonorHealth Scottsdale Thompson Peak Medical Center, 7400 E Thompson Peak Pkwy, Scottsdale, AZ 85255, United StatesHonorHealth Scottsdale Thompson Peak Medical Center, 7400 E Thompson Peak Pkwy, Scottsdale, AZ 85255, United StatesMycobacterium xenopi, a nontuberculous mycobacterium (NTM), presents a significant diagnostic challenge in clinical practice, particularly in immunocompromised individuals. We report a case of M. xenopi infection in a liver transplant recipient on immunosuppressive medication. A 67-year-old male presented with chronic cough, anemia, and significant weight loss. Imaging studies revealed extensive pulmonary involvement with cavitations. More definitively, an acid-fast bacilli (AFB) bronchoalveolar lavage culture as well as an acid-fast bacilli (AFB) sputum culture confirmed M. xenopi infection. Treatment initiation with multiple antimicrobial agents was guided by susceptibility testing and published recommendations by the Infectious Disease Society of America and the American Thoracic Society guidelines from 2020 (Kurz, et al., 2020). This case emphasizes the importance of considering non-tubercular bacterial infections, particularly M. xenopi, in the differential diagnosis of respiratory symptoms in immunocompromised hosts. In addition to the case report, this paper provides a comprehensive review of the epidemiology, risk factors, clinical manifestations, diagnostic challenges, and treatment strategies for M. xenopi infections.http://www.sciencedirect.com/science/article/pii/S259017022400044X
spellingShingle Julie Lee
Kara Asbury
Rhea Ram
Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive review
Clinical Infection in Practice
title Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive review
title_full Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive review
title_fullStr Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive review
title_full_unstemmed Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive review
title_short Mycobacterium xenopi infection in an immunocompromised liver transplant recipient: A case report and comprehensive review
title_sort mycobacterium xenopi infection in an immunocompromised liver transplant recipient a case report and comprehensive review
url http://www.sciencedirect.com/science/article/pii/S259017022400044X
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AT karaasbury mycobacteriumxenopiinfectioninanimmunocompromisedlivertransplantrecipientacasereportandcomprehensivereview
AT rhearam mycobacteriumxenopiinfectioninanimmunocompromisedlivertransplantrecipientacasereportandcomprehensivereview