Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational study
ABSTRACT Objective: To evaluate the efficacy of high-dose oral riboflavin treatment combined with sun exposure in preventing the progression of keratoconus. Methods: A retrospective, multicenter observational study involving 53 keratoconus patients (106 eyes) from three Brazilian cities. Patients...
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Sociedade Brasileira de Oftalmologia
2025-06-01
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| Series: | Revista Brasileira de Oftalmologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100220&lng=en&tlng=en |
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| author | Edna Motta Almodin Flávia Almodin Juliana Almodin |
| author_facet | Edna Motta Almodin Flávia Almodin Juliana Almodin |
| author_sort | Edna Motta Almodin |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate the efficacy of high-dose oral riboflavin treatment combined with sun exposure in preventing the progression of keratoconus. Methods: A retrospective, multicenter observational study involving 53 keratoconus patients (106 eyes) from three Brazilian cities. Patients were instructed to take 400 mg/day of oral riboflavin and to sunbathe for 30 minutes daily, in addition to avoiding eye rubbing. Keratometric measurements were evaluated before and after 6, 12, 24, and 36 months of treatment. Results: After 6 months, 42 patients remained in the study. Corneal flattening was observed without significant decrease in thickness. At 36 months, stabilization of keratoconus was noted, with minor variations in astigmatism and corneal thickness measurements. Conclusion: Oral riboflavin treatment combined with sun exposure appears to be effective in stabilizing the progression of keratoconus. |
| format | Article |
| id | doaj-art-e95abe04fb2e4435b3c6e7c659cf07fd |
| institution | OA Journals |
| issn | 1982-8551 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sociedade Brasileira de Oftalmologia |
| record_format | Article |
| series | Revista Brasileira de Oftalmologia |
| spelling | doaj-art-e95abe04fb2e4435b3c6e7c659cf07fd2025-08-20T02:38:43ZengSociedade Brasileira de OftalmologiaRevista Brasileira de Oftalmologia1982-85512025-06-018410.37039/1982.8551.20250036Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational studyEdna Motta Almodinhttps://orcid.org/0000-0002-7609-4432Flávia Almodinhttps://orcid.org/0000-0001-6497-8591Juliana Almodinhttps://orcid.org/0000-0001-6798-1307ABSTRACT Objective: To evaluate the efficacy of high-dose oral riboflavin treatment combined with sun exposure in preventing the progression of keratoconus. Methods: A retrospective, multicenter observational study involving 53 keratoconus patients (106 eyes) from three Brazilian cities. Patients were instructed to take 400 mg/day of oral riboflavin and to sunbathe for 30 minutes daily, in addition to avoiding eye rubbing. Keratometric measurements were evaluated before and after 6, 12, 24, and 36 months of treatment. Results: After 6 months, 42 patients remained in the study. Corneal flattening was observed without significant decrease in thickness. At 36 months, stabilization of keratoconus was noted, with minor variations in astigmatism and corneal thickness measurements. Conclusion: Oral riboflavin treatment combined with sun exposure appears to be effective in stabilizing the progression of keratoconus.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100220&lng=en&tlng=enKeratoconusCorneal cross-linkingRiboflavinDisease progression |
| spellingShingle | Edna Motta Almodin Flávia Almodin Juliana Almodin Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational study Revista Brasileira de Oftalmologia Keratoconus Corneal cross-linking Riboflavin Disease progression |
| title | Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational study |
| title_full | Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational study |
| title_fullStr | Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational study |
| title_full_unstemmed | Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational study |
| title_short | Corneal collagen cross-linking by sun exposure and high dose oral riboflavin: a multicentric longitudinal observational study |
| title_sort | corneal collagen cross linking by sun exposure and high dose oral riboflavin a multicentric longitudinal observational study |
| topic | Keratoconus Corneal cross-linking Riboflavin Disease progression |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100220&lng=en&tlng=en |
| work_keys_str_mv | AT ednamottaalmodin cornealcollagencrosslinkingbysunexposureandhighdoseoralriboflavinamulticentriclongitudinalobservationalstudy AT flaviaalmodin cornealcollagencrosslinkingbysunexposureandhighdoseoralriboflavinamulticentriclongitudinalobservationalstudy AT julianaalmodin cornealcollagencrosslinkingbysunexposureandhighdoseoralriboflavinamulticentriclongitudinalobservationalstudy |