TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis
TREM-1 and TREM-2 molecules are members of the TREM transmembrane glycoproteins. In our previous study we identified increased expressions of TREM-1 and TREM-2 receptors in pulmonary sarcoidosis (PS). Only a few studies concerning the association between vitamin D and TREM receptor expression can be...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/181986 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548712486797312 |
|---|---|
| author | Maria Bucova Magda Suchankova Elena Tibenska Eva Tedlova Juraj Demian Ivan Majer Helena Novosadova Miroslav Tedla |
| author_facet | Maria Bucova Magda Suchankova Elena Tibenska Eva Tedlova Juraj Demian Ivan Majer Helena Novosadova Miroslav Tedla |
| author_sort | Maria Bucova |
| collection | DOAJ |
| description | TREM-1 and TREM-2 molecules are members of the TREM transmembrane glycoproteins. In our previous study we identified increased expressions of TREM-1 and TREM-2 receptors in pulmonary sarcoidosis (PS). Only a few studies concerning the association between vitamin D and TREM receptor expression can be found. The aim of our current study was to determine the association between the levels of an inactive form of 25(OH)D vitamin and TREM-1 and TREM-2 receptor expressions. We have detected low levels of 25(OH)D vitamin in 79% of PS patients. Only 21% of patients had normal serum level of 25(OH)D vitamin with values clustered within the low-normal range. The most striking findings were the increased TREM-2 expressions on myeloid cells surfaces in BALF of PS patients with normal 25(OH)D vitamin serum levels compared with those with its decreased levels. The total number of TREM-2 positive cells was 5.7 times higher and the percentage of TREM-2 positive cells was also significantly increased in BALF of PS patients with normal compared to PS patients with low 25(OH)D vitamin serum levels. A significant correlation between total TREM-2 expression and vitamin D levels has been detected too. However, we have not detected similar differences in TREM-1expression and 25(OH)D vitamin serum levels. |
| format | Article |
| id | doaj-art-e95a8430d02c40ba98ad75a10bf0357e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e95a8430d02c40ba98ad75a10bf0357e2025-02-03T06:13:22ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/181986181986TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary SarcoidosisMaria Bucova0Magda Suchankova1Elena Tibenska2Eva Tedlova3Juraj Demian4Ivan Majer5Helena Novosadova6Miroslav Tedla7Institute of Immunology, Faculty of Medicine, Comenius University, 81372 Bratislava, SlovakiaInstitute of Immunology, Faculty of Medicine, Comenius University, 81372 Bratislava, SlovakiaMedirex Ltd., 82016 Bratislava, SlovakiaDepartment of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, SlovakiaDepartment of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, SlovakiaDepartment of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, SlovakiaDepartment of Pneumology and Phthisiology, Faculty of Medicine, Comenius University, 82101 Bratislava, Slovakia1st Department of Otorhinolaryngology, Faculty of Medicine, Comenius University, 85107 Bratislava, SlovakiaTREM-1 and TREM-2 molecules are members of the TREM transmembrane glycoproteins. In our previous study we identified increased expressions of TREM-1 and TREM-2 receptors in pulmonary sarcoidosis (PS). Only a few studies concerning the association between vitamin D and TREM receptor expression can be found. The aim of our current study was to determine the association between the levels of an inactive form of 25(OH)D vitamin and TREM-1 and TREM-2 receptor expressions. We have detected low levels of 25(OH)D vitamin in 79% of PS patients. Only 21% of patients had normal serum level of 25(OH)D vitamin with values clustered within the low-normal range. The most striking findings were the increased TREM-2 expressions on myeloid cells surfaces in BALF of PS patients with normal 25(OH)D vitamin serum levels compared with those with its decreased levels. The total number of TREM-2 positive cells was 5.7 times higher and the percentage of TREM-2 positive cells was also significantly increased in BALF of PS patients with normal compared to PS patients with low 25(OH)D vitamin serum levels. A significant correlation between total TREM-2 expression and vitamin D levels has been detected too. However, we have not detected similar differences in TREM-1expression and 25(OH)D vitamin serum levels.http://dx.doi.org/10.1155/2015/181986 |
| spellingShingle | Maria Bucova Magda Suchankova Elena Tibenska Eva Tedlova Juraj Demian Ivan Majer Helena Novosadova Miroslav Tedla TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis Mediators of Inflammation |
| title | TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis |
| title_full | TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis |
| title_fullStr | TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis |
| title_full_unstemmed | TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis |
| title_short | TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis |
| title_sort | trem 2 receptor expression increases with 25 oh d vitamin serum levels in patients with pulmonary sarcoidosis |
| url | http://dx.doi.org/10.1155/2015/181986 |
| work_keys_str_mv | AT mariabucova trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis AT magdasuchankova trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis AT elenatibenska trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis AT evatedlova trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis AT jurajdemian trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis AT ivanmajer trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis AT helenanovosadova trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis AT miroslavtedla trem2receptorexpressionincreaseswith25ohdvitaminserumlevelsinpatientswithpulmonarysarcoidosis |