Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases
Introduction Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare, molecularly defined renal tumor with aggressive behavior. The diagnosis of these tumors is challenging because of varied morphology and limited access to molecular testing and immunohistochemistry (IHC) f...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2024-12-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775804 |
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| author | Aswathy A. Menon Swapnil Rane Uma Sakhadeo Gagan Prakash Amit Joshi Mahendra Pal Amandeep Arora Nilesh Sable Aparna Katdare Palak Popat Priyamvada Maitre Archi Agarwal Vedang Murthy Sangeetha B. Desai Santosh Menon |
| author_facet | Aswathy A. Menon Swapnil Rane Uma Sakhadeo Gagan Prakash Amit Joshi Mahendra Pal Amandeep Arora Nilesh Sable Aparna Katdare Palak Popat Priyamvada Maitre Archi Agarwal Vedang Murthy Sangeetha B. Desai Santosh Menon |
| author_sort | Aswathy A. Menon |
| collection | DOAJ |
| description |
Introduction Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare, molecularly defined renal tumor with aggressive behavior. The diagnosis of these tumors is challenging because of varied morphology and limited access to molecular testing and immunohistochemistry (IHC) for FH and 2-succinocysteine. We aim to elucidate the histomorphology, clinical presentation, and follow-up of this tumor in this first series of cases of FH-deficient RCCs from India. |
| format | Article |
| id | doaj-art-e95621eda32843b5a9d062a03185721e |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-e95621eda32843b5a9d062a03185721e2025-08-20T02:22:34ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292024-12-01450650250810.1055/s-0043-1775804Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 CasesAswathy A. Menon0https://orcid.org/0000-0002-1363-7073Swapnil Rane1https://orcid.org/0000-0002-5374-3903Uma Sakhadeo2Gagan Prakash3https://orcid.org/0000-0003-1722-4337Amit Joshi4Mahendra Pal5Amandeep Arora6Nilesh Sable7Aparna Katdare8Palak Popat9Priyamvada Maitre10Archi Agarwal11Vedang Murthy12Sangeetha B. Desai13https://orcid.org/0000-0002-3588-9888Santosh Menon14https://orcid.org/0000-0002-4140-0671Department of Pathology, Neuberg Anand Reference Laboratory, Bengaluru, Karnataka, IndiaDepartment of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Urology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Urology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Urology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiation Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Nuclear Medicine, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiation Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India Introduction Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare, molecularly defined renal tumor with aggressive behavior. The diagnosis of these tumors is challenging because of varied morphology and limited access to molecular testing and immunohistochemistry (IHC) for FH and 2-succinocysteine. We aim to elucidate the histomorphology, clinical presentation, and follow-up of this tumor in this first series of cases of FH-deficient RCCs from India.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775804fumarate hydratase-deficient renal cell carcinomafumarate hydrataseRCCFH IHCHLRCC |
| spellingShingle | Aswathy A. Menon Swapnil Rane Uma Sakhadeo Gagan Prakash Amit Joshi Mahendra Pal Amandeep Arora Nilesh Sable Aparna Katdare Palak Popat Priyamvada Maitre Archi Agarwal Vedang Murthy Sangeetha B. Desai Santosh Menon Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases Indian Journal of Medical and Paediatric Oncology fumarate hydratase-deficient renal cell carcinoma fumarate hydratase RCC FH IHC HLRCC |
| title | Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases |
| title_full | Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases |
| title_fullStr | Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases |
| title_full_unstemmed | Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases |
| title_short | Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases |
| title_sort | fumarate hydratase deficient renal cell carcinoma a clinicopathological study of a series of 11 cases |
| topic | fumarate hydratase-deficient renal cell carcinoma fumarate hydratase RCC FH IHC HLRCC |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775804 |
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