Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue
Methylene blue is a phenothiazine-related heterocyclic aromatic molecule presently used in the treatment of methemoglobinemia. Recently, it has been implicated in the treatment of severe refractory vasoplegic shock caused by anaphylaxis, sepsis, or postcardiopulmonary bypass. We present a case of a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2017/8747326 |
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| _version_ | 1850163552514473984 |
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| author | Farheen Manji Benjamin Wierstra Juan Posadas |
| author_facet | Farheen Manji Benjamin Wierstra Juan Posadas |
| author_sort | Farheen Manji |
| collection | DOAJ |
| description | Methylene blue is a phenothiazine-related heterocyclic aromatic molecule presently used in the treatment of methemoglobinemia. Recently, it has been implicated in the treatment of severe refractory vasoplegic shock caused by anaphylaxis, sepsis, or postcardiopulmonary bypass. We present a case of a 27-year-old male with profound vasoplegic shock of unknown etiology which was refractory to vasopressors who responded within hours to a single dose of methylene blue. Additionally, we review the evidence of methylene blue’s role in the treatment of shock. This case illustrates a diagnostic approach and treatment options in the setting of undifferentiated vasodilatory shock and outlines a new and emerging role for methylene blue in this clinical setting. |
| format | Article |
| id | doaj-art-e955ffcae9e142499491caf04efc2f79 |
| institution | OA Journals |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-e955ffcae9e142499491caf04efc2f792025-08-20T02:22:15ZengWileyCase Reports in Critical Care2090-64202090-64392017-01-01201710.1155/2017/87473268747326Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene BlueFarheen Manji0Benjamin Wierstra1Juan Posadas2University of Calgary and Alberta Health Services, Calgary, AB, CanadaUniversity of Calgary and Alberta Health Services, Calgary, AB, CanadaUniversity of Calgary and Alberta Health Services, Calgary, AB, CanadaMethylene blue is a phenothiazine-related heterocyclic aromatic molecule presently used in the treatment of methemoglobinemia. Recently, it has been implicated in the treatment of severe refractory vasoplegic shock caused by anaphylaxis, sepsis, or postcardiopulmonary bypass. We present a case of a 27-year-old male with profound vasoplegic shock of unknown etiology which was refractory to vasopressors who responded within hours to a single dose of methylene blue. Additionally, we review the evidence of methylene blue’s role in the treatment of shock. This case illustrates a diagnostic approach and treatment options in the setting of undifferentiated vasodilatory shock and outlines a new and emerging role for methylene blue in this clinical setting.http://dx.doi.org/10.1155/2017/8747326 |
| spellingShingle | Farheen Manji Benjamin Wierstra Juan Posadas Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue Case Reports in Critical Care |
| title | Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue |
| title_full | Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue |
| title_fullStr | Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue |
| title_full_unstemmed | Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue |
| title_short | Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue |
| title_sort | severe undifferentiated vasoplegic shock refractory to vasoactive agents treated with methylene blue |
| url | http://dx.doi.org/10.1155/2017/8747326 |
| work_keys_str_mv | AT farheenmanji severeundifferentiatedvasoplegicshockrefractorytovasoactiveagentstreatedwithmethyleneblue AT benjaminwierstra severeundifferentiatedvasoplegicshockrefractorytovasoactiveagentstreatedwithmethyleneblue AT juanposadas severeundifferentiatedvasoplegicshockrefractorytovasoactiveagentstreatedwithmethyleneblue |