Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysis
Background: Immunohistochemistry (IHC) provides comprehensive information for morphology and pathologic characteristics and is a valuable tool for establishing the correct cancer diagnosis in clinical diagnostic pathology and determining prognosis. Objectives: The current study analyzes and compares...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-03-01
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| Series: | Rare Tumors |
| Online Access: | https://doi.org/10.1177/20363613251330179 |
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| author | Hedieh Soltani Mojtaba Ahmadinejad Arman Shafiee Fatemeh Afshar Rezaee Mahya Beik Mohamadi Atefeh Bahrambeigi Amir Hossein Hajialigol Saeedeh Fattan Javad Zebarjadi Bagherpour |
| author_facet | Hedieh Soltani Mojtaba Ahmadinejad Arman Shafiee Fatemeh Afshar Rezaee Mahya Beik Mohamadi Atefeh Bahrambeigi Amir Hossein Hajialigol Saeedeh Fattan Javad Zebarjadi Bagherpour |
| author_sort | Hedieh Soltani |
| collection | DOAJ |
| description | Background: Immunohistochemistry (IHC) provides comprehensive information for morphology and pathologic characteristics and is a valuable tool for establishing the correct cancer diagnosis in clinical diagnostic pathology and determining prognosis. Objectives: The current study analyzes and compares the expression of Immunohistochemistry biomarkers on neuroendocrine and epithelial cell types of appendiceal neoplasms. Design: This systematic review adhered to the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. We performed a meta-analysis employing a random effects model with proportions to gauge the proportion of positive cases. Method: A comprehensive systematic search in PubMed, Web of Science, and Scopus databases was conducted based on the PRISMA statement up to August 2023. Studies reporting the immunohistochemistry biomarkers expression performed in patients with primary appendiceal neuroendocrine and epithelial cell neoplasms according to the most recent World Health Organization classification of malignant tumors were included. Results: Our systematic search included 56 observational articles that meet the eligibility criteria. Meta-analysis revealed an expression rate of 93%, 91%, 87%, 71%, 94%, 99%, 32%, 76%, 25%, and 91% for non-specific enolase (NSE), chromaffin A, synaptophysin, Serotonin, SATB2, Caudal-type homeobox 2 (CDX2), β-catenin, Carcinoembryonic antigen (CEA), Cytokeratin 7, and Cytokeratin 20, respectively. CDX2 and SATB2 were the most expressed markers. The expression rate had a significant association with tumor type. NSE and synaptophysin were the highest in neuroendocrine tumors, whereas CEA was more elevated in gablet cell carcinoids. Cytokeratin 20 is suitable for identifying epithelial cell neoplasms. Conclusion: The study indicates the proportion of positive cases in patients with primary neuroendocrine and epithelial cell appendiceal neoplasms. |
| format | Article |
| id | doaj-art-e953ccb4f4c2437b858b6302ad7d8842 |
| institution | DOAJ |
| issn | 2036-3613 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj-art-e953ccb4f4c2437b858b6302ad7d88422025-08-20T03:04:26ZengSAGE PublishingRare Tumors2036-36132025-03-011710.1177/20363613251330179Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysisHedieh SoltaniMojtaba AhmadinejadArman ShafieeFatemeh Afshar RezaeeMahya Beik MohamadiAtefeh BahrambeigiAmir Hossein HajialigolSaeedeh FattanJavad Zebarjadi BagherpourBackground: Immunohistochemistry (IHC) provides comprehensive information for morphology and pathologic characteristics and is a valuable tool for establishing the correct cancer diagnosis in clinical diagnostic pathology and determining prognosis. Objectives: The current study analyzes and compares the expression of Immunohistochemistry biomarkers on neuroendocrine and epithelial cell types of appendiceal neoplasms. Design: This systematic review adhered to the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. We performed a meta-analysis employing a random effects model with proportions to gauge the proportion of positive cases. Method: A comprehensive systematic search in PubMed, Web of Science, and Scopus databases was conducted based on the PRISMA statement up to August 2023. Studies reporting the immunohistochemistry biomarkers expression performed in patients with primary appendiceal neuroendocrine and epithelial cell neoplasms according to the most recent World Health Organization classification of malignant tumors were included. Results: Our systematic search included 56 observational articles that meet the eligibility criteria. Meta-analysis revealed an expression rate of 93%, 91%, 87%, 71%, 94%, 99%, 32%, 76%, 25%, and 91% for non-specific enolase (NSE), chromaffin A, synaptophysin, Serotonin, SATB2, Caudal-type homeobox 2 (CDX2), β-catenin, Carcinoembryonic antigen (CEA), Cytokeratin 7, and Cytokeratin 20, respectively. CDX2 and SATB2 were the most expressed markers. The expression rate had a significant association with tumor type. NSE and synaptophysin were the highest in neuroendocrine tumors, whereas CEA was more elevated in gablet cell carcinoids. Cytokeratin 20 is suitable for identifying epithelial cell neoplasms. Conclusion: The study indicates the proportion of positive cases in patients with primary neuroendocrine and epithelial cell appendiceal neoplasms.https://doi.org/10.1177/20363613251330179 |
| spellingShingle | Hedieh Soltani Mojtaba Ahmadinejad Arman Shafiee Fatemeh Afshar Rezaee Mahya Beik Mohamadi Atefeh Bahrambeigi Amir Hossein Hajialigol Saeedeh Fattan Javad Zebarjadi Bagherpour Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysis Rare Tumors |
| title | Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysis |
| title_full | Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysis |
| title_fullStr | Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysis |
| title_full_unstemmed | Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysis |
| title_short | Expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms: Systematic review and meta-analysis |
| title_sort | expression rate and comparison of immunohistochemistry biomarkers in appendiceal neuroendocrine and other epithelial cell neoplasms systematic review and meta analysis |
| url | https://doi.org/10.1177/20363613251330179 |
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