Faecal microbiota transplantation protects against radiation‐induced toxicity
Abstract Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation‐induced toxicity. High‐thr...
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| Format: | Article |
| Language: | English |
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Springer Nature
2017-02-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201606932 |
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| author | Ming Cui Huiwen Xiao Yuan Li Lixin Zhou Shuyi Zhao Dan Luo Qisheng Zheng Jiali Dong Yu Zhao Xin Zhang Junling Zhang Lu Lu Haichao Wang Saijun Fan |
| author_facet | Ming Cui Huiwen Xiao Yuan Li Lixin Zhou Shuyi Zhao Dan Luo Qisheng Zheng Jiali Dong Yu Zhao Xin Zhang Junling Zhang Lu Lu Haichao Wang Saijun Fan |
| author_sort | Ming Cui |
| collection | DOAJ |
| description | Abstract Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation‐induced toxicity. High‐throughput sequencing showed that gastrointestinal bacterial community composition differed between male and female mice and was associated with susceptibility to radiation toxicity. Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice. FMT preserved the intestinal bacterial composition and retained mRNA and long non‐coding RNA expression profiles of host small intestines in a sex‐specific fashion. Despite promoting angiogenesis, sex‐matched FMT did not accelerate the proliferation of cancer cells in vivo. FMT might serve as a therapeutic to mitigate radiation‐induced toxicity and improve the prognosis of tumour patients after radiotherapy. |
| format | Article |
| id | doaj-art-e94d60efff694f6bb8da99b74c487934 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-e94d60efff694f6bb8da99b74c4879342025-08-20T04:02:56ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842017-02-019444846110.15252/emmm.201606932Faecal microbiota transplantation protects against radiation‐induced toxicityMing Cui0Huiwen Xiao1Yuan Li2Lixin Zhou3Shuyi Zhao4Dan Luo5Qisheng Zheng6Jiali Dong7Yu Zhao8Xin Zhang9Junling Zhang10Lu Lu11Haichao Wang12Saijun Fan13Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pathology, Peking University Cancer Hospital & InstituteTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation‐induced toxicity. High‐throughput sequencing showed that gastrointestinal bacterial community composition differed between male and female mice and was associated with susceptibility to radiation toxicity. Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice. FMT preserved the intestinal bacterial composition and retained mRNA and long non‐coding RNA expression profiles of host small intestines in a sex‐specific fashion. Despite promoting angiogenesis, sex‐matched FMT did not accelerate the proliferation of cancer cells in vivo. FMT might serve as a therapeutic to mitigate radiation‐induced toxicity and improve the prognosis of tumour patients after radiotherapy.https://doi.org/10.15252/emmm.201606932faecal microbiota transplantationgastrointestinal toxicitygut microbiotaradiation syndromeradiotherapy |
| spellingShingle | Ming Cui Huiwen Xiao Yuan Li Lixin Zhou Shuyi Zhao Dan Luo Qisheng Zheng Jiali Dong Yu Zhao Xin Zhang Junling Zhang Lu Lu Haichao Wang Saijun Fan Faecal microbiota transplantation protects against radiation‐induced toxicity EMBO Molecular Medicine faecal microbiota transplantation gastrointestinal toxicity gut microbiota radiation syndrome radiotherapy |
| title | Faecal microbiota transplantation protects against radiation‐induced toxicity |
| title_full | Faecal microbiota transplantation protects against radiation‐induced toxicity |
| title_fullStr | Faecal microbiota transplantation protects against radiation‐induced toxicity |
| title_full_unstemmed | Faecal microbiota transplantation protects against radiation‐induced toxicity |
| title_short | Faecal microbiota transplantation protects against radiation‐induced toxicity |
| title_sort | faecal microbiota transplantation protects against radiation induced toxicity |
| topic | faecal microbiota transplantation gastrointestinal toxicity gut microbiota radiation syndrome radiotherapy |
| url | https://doi.org/10.15252/emmm.201606932 |
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