3D tumor cultures for drug resistance and screening development in clinical applications
Abstract Tumor drug resistance presents a growing challenge in medical practice, particularly during anti-cancer therapies, where the emergence of drug-resistant cancer cells significantly complicates clinical treatment. In recent years, three-dimensional (3D) tumor culture technology, which more ef...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
|
| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-025-02281-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849389950433230848 |
|---|---|
| author | Zheng Peng Xiaolan Lv Hao Sun Lina Zhao Shigao Huang |
| author_facet | Zheng Peng Xiaolan Lv Hao Sun Lina Zhao Shigao Huang |
| author_sort | Zheng Peng |
| collection | DOAJ |
| description | Abstract Tumor drug resistance presents a growing challenge in medical practice, particularly during anti-cancer therapies, where the emergence of drug-resistant cancer cells significantly complicates clinical treatment. In recent years, three-dimensional (3D) tumor culture technology, which more effectively simulates the in vivo physiological environment, has gained increasing attention in tumor drug resistance research and clinical applications. By mimicking the in vivo cellular microenvironment, 3D tumor culture technology not only recapitulates cell-cell interactions but also more faithfully reproduces the biological effects of therapeutic agents. Consequently, 3D tumor culture technology is emerging as a crucial tool in biomedical and clinical research. We summarize the benefits of 3D culture models and organoid technology, explore their application in the realm of drug resistance, drug screening, and personalized therapy, and discuss their potential application prospects and challenges in clinical transformation, with the aim of providing insights for optimizing cancer treatment strategies and advancing precision therapy. |
| format | Article |
| id | doaj-art-e94c725bd5d442f6bb9b780b02b31efd |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-e94c725bd5d442f6bb9b780b02b31efd2025-08-20T03:41:49ZengBMCMolecular Cancer1476-45982025-03-0124111610.1186/s12943-025-02281-23D tumor cultures for drug resistance and screening development in clinical applicationsZheng Peng0Xiaolan Lv1Hao Sun2Lina Zhao3Shigao Huang4Department of Clinical Laboratory, Liuzhou Traditional Chinese Medical HospitalDepartment of Clinical Laboratory, Liuzhou Maternity and Child Healthcare HospitalFaculty of Science, Autonomous University of Madrid, Spainish National Research Council -Consejo Superior de Investigaciones Científicas,(UAM-CSIC)State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical UniversityDepartment of Radiation Oncology, Xijing Hospital, Fourth Military Medical UniversityAbstract Tumor drug resistance presents a growing challenge in medical practice, particularly during anti-cancer therapies, where the emergence of drug-resistant cancer cells significantly complicates clinical treatment. In recent years, three-dimensional (3D) tumor culture technology, which more effectively simulates the in vivo physiological environment, has gained increasing attention in tumor drug resistance research and clinical applications. By mimicking the in vivo cellular microenvironment, 3D tumor culture technology not only recapitulates cell-cell interactions but also more faithfully reproduces the biological effects of therapeutic agents. Consequently, 3D tumor culture technology is emerging as a crucial tool in biomedical and clinical research. We summarize the benefits of 3D culture models and organoid technology, explore their application in the realm of drug resistance, drug screening, and personalized therapy, and discuss their potential application prospects and challenges in clinical transformation, with the aim of providing insights for optimizing cancer treatment strategies and advancing precision therapy.https://doi.org/10.1186/s12943-025-02281-2Cancer resistance3D tumor culture modelOrganoidsTumor microenvironmentDrug screening |
| spellingShingle | Zheng Peng Xiaolan Lv Hao Sun Lina Zhao Shigao Huang 3D tumor cultures for drug resistance and screening development in clinical applications Molecular Cancer Cancer resistance 3D tumor culture model Organoids Tumor microenvironment Drug screening |
| title | 3D tumor cultures for drug resistance and screening development in clinical applications |
| title_full | 3D tumor cultures for drug resistance and screening development in clinical applications |
| title_fullStr | 3D tumor cultures for drug resistance and screening development in clinical applications |
| title_full_unstemmed | 3D tumor cultures for drug resistance and screening development in clinical applications |
| title_short | 3D tumor cultures for drug resistance and screening development in clinical applications |
| title_sort | 3d tumor cultures for drug resistance and screening development in clinical applications |
| topic | Cancer resistance 3D tumor culture model Organoids Tumor microenvironment Drug screening |
| url | https://doi.org/10.1186/s12943-025-02281-2 |
| work_keys_str_mv | AT zhengpeng 3dtumorculturesfordrugresistanceandscreeningdevelopmentinclinicalapplications AT xiaolanlv 3dtumorculturesfordrugresistanceandscreeningdevelopmentinclinicalapplications AT haosun 3dtumorculturesfordrugresistanceandscreeningdevelopmentinclinicalapplications AT linazhao 3dtumorculturesfordrugresistanceandscreeningdevelopmentinclinicalapplications AT shigaohuang 3dtumorculturesfordrugresistanceandscreeningdevelopmentinclinicalapplications |