Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes
A series of trans-6-phenylethenyl substituted pyridoxine derivatives, novel bioisosteric analogs of drugs based on trans-stilbene scaffold, were synthesized using the Wittig reaction of a bis-triphenylphosphonium pyridoxine derivative with various aromatic aldehydes. Two compounds demonstrated high...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/8281518 |
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| author | Mikhail V. Pugachev Thang T. N. Nguyen Timur M. Bulatov Roman S. Pavelyev Alfia G. Iksanova Oksana V. Bondar Konstantin V. Balakin Yurii G. Shtyrlin |
| author_facet | Mikhail V. Pugachev Thang T. N. Nguyen Timur M. Bulatov Roman S. Pavelyev Alfia G. Iksanova Oksana V. Bondar Konstantin V. Balakin Yurii G. Shtyrlin |
| author_sort | Mikhail V. Pugachev |
| collection | DOAJ |
| description | A series of trans-6-phenylethenyl substituted pyridoxine derivatives, novel bioisosteric analogs of drugs based on trans-stilbene scaffold, were synthesized using the Wittig reaction of a bis-triphenylphosphonium pyridoxine derivative with various aromatic aldehydes. Two compounds demonstrated high activity against the estrogen-dependent MCF-7 (breast cancer) cell line with IC50 in the range of 1.9–7.9 µM and very good selectivity for other studied normal and tumor cells, including the estrogen receptor negative MDA-MB-231 breast cancer cells. The active compounds possessed an intense blue fluorescence, and this feature allowed us to effectively visualize them in cytoplasm and in nucleus. The obtained results make the described chemotype a promising starting point for the development of new anticancer agents for the therapy of estrogen-dependent malignancies. |
| format | Article |
| id | doaj-art-e9468e5668a14e069cfc2b7b17302744 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e9468e5668a14e069cfc2b7b173027442025-02-03T06:00:24ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/82815188281518Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-StilbenesMikhail V. Pugachev0Thang T. N. Nguyen1Timur M. Bulatov2Roman S. Pavelyev3Alfia G. Iksanova4Oksana V. Bondar5Konstantin V. Balakin6Yurii G. Shtyrlin7Kazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaKazan (Volga Region) Federal University, Kremlyovskaya 18, Kazan 420008, RussiaA series of trans-6-phenylethenyl substituted pyridoxine derivatives, novel bioisosteric analogs of drugs based on trans-stilbene scaffold, were synthesized using the Wittig reaction of a bis-triphenylphosphonium pyridoxine derivative with various aromatic aldehydes. Two compounds demonstrated high activity against the estrogen-dependent MCF-7 (breast cancer) cell line with IC50 in the range of 1.9–7.9 µM and very good selectivity for other studied normal and tumor cells, including the estrogen receptor negative MDA-MB-231 breast cancer cells. The active compounds possessed an intense blue fluorescence, and this feature allowed us to effectively visualize them in cytoplasm and in nucleus. The obtained results make the described chemotype a promising starting point for the development of new anticancer agents for the therapy of estrogen-dependent malignancies.http://dx.doi.org/10.1155/2017/8281518 |
| spellingShingle | Mikhail V. Pugachev Thang T. N. Nguyen Timur M. Bulatov Roman S. Pavelyev Alfia G. Iksanova Oksana V. Bondar Konstantin V. Balakin Yurii G. Shtyrlin Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes Journal of Chemistry |
| title | Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes |
| title_full | Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes |
| title_fullStr | Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes |
| title_full_unstemmed | Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes |
| title_short | Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes |
| title_sort | synthesis and antitumor activity of novel pyridoxine based bioisosteric analogs of trans stilbenes |
| url | http://dx.doi.org/10.1155/2017/8281518 |
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