Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5153184 |
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| author | Lina Mattson Antonio Lentini Danuta R. Gawel Tejaswi V. S. Badam Mikael Benson Torbjorn Ledin Colm E. Nestor Mika Gustafsson Jordi Serra-Musach Janne Bjorkander Zou Xiang Huan Zhang |
| author_facet | Lina Mattson Antonio Lentini Danuta R. Gawel Tejaswi V. S. Badam Mikael Benson Torbjorn Ledin Colm E. Nestor Mika Gustafsson Jordi Serra-Musach Janne Bjorkander Zou Xiang Huan Zhang |
| author_sort | Lina Mattson |
| collection | DOAJ |
| description | Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4+ T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies. |
| format | Article |
| id | doaj-art-e945d86dd2e1499eb3b7a6309cbf5feb |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e945d86dd2e1499eb3b7a6309cbf5feb2025-02-03T01:02:42ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/51531845153184Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic RhinitisLina Mattson0Antonio Lentini1Danuta R. Gawel2Tejaswi V. S. Badam3Mikael Benson4Torbjorn Ledin5Colm E. Nestor6Mika Gustafsson7Jordi Serra-Musach8Janne Bjorkander9Zou Xiang10Huan Zhang11The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenDivision of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenFuturum-Academy for Health and Care, County Council of Jonkoping, Jonkoping, SwedenDepartment of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong KongThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenSpecific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4+ T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.http://dx.doi.org/10.1155/2016/5153184 |
| spellingShingle | Lina Mattson Antonio Lentini Danuta R. Gawel Tejaswi V. S. Badam Mikael Benson Torbjorn Ledin Colm E. Nestor Mika Gustafsson Jordi Serra-Musach Janne Bjorkander Zou Xiang Huan Zhang Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis Journal of Immunology Research |
| title | Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis |
| title_full | Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis |
| title_fullStr | Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis |
| title_full_unstemmed | Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis |
| title_short | Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis |
| title_sort | potential involvement of type i interferon signaling in immunotherapy in seasonal allergic rhinitis |
| url | http://dx.doi.org/10.1155/2016/5153184 |
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