Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis

Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive...

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Main Authors: Lina Mattson, Antonio Lentini, Danuta R. Gawel, Tejaswi V. S. Badam, Mikael Benson, Torbjorn Ledin, Colm E. Nestor, Mika Gustafsson, Jordi Serra-Musach, Janne Bjorkander, Zou Xiang, Huan Zhang
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2016/5153184
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author Lina Mattson
Antonio Lentini
Danuta R. Gawel
Tejaswi V. S. Badam
Mikael Benson
Torbjorn Ledin
Colm E. Nestor
Mika Gustafsson
Jordi Serra-Musach
Janne Bjorkander
Zou Xiang
Huan Zhang
author_facet Lina Mattson
Antonio Lentini
Danuta R. Gawel
Tejaswi V. S. Badam
Mikael Benson
Torbjorn Ledin
Colm E. Nestor
Mika Gustafsson
Jordi Serra-Musach
Janne Bjorkander
Zou Xiang
Huan Zhang
author_sort Lina Mattson
collection DOAJ
description Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4+ T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.
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institution Kabale University
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language English
publishDate 2016-01-01
publisher Wiley
record_format Article
series Journal of Immunology Research
spelling doaj-art-e945d86dd2e1499eb3b7a6309cbf5feb2025-02-03T01:02:42ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/51531845153184Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic RhinitisLina Mattson0Antonio Lentini1Danuta R. Gawel2Tejaswi V. S. Badam3Mikael Benson4Torbjorn Ledin5Colm E. Nestor6Mika Gustafsson7Jordi Serra-Musach8Janne Bjorkander9Zou Xiang10Huan Zhang11The Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenDivision of Neuro and Inflammation Science, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenFuturum-Academy for Health and Care, County Council of Jonkoping, Jonkoping, SwedenDepartment of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong KongThe Centre for Personalized Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, SwedenSpecific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4+ T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.http://dx.doi.org/10.1155/2016/5153184
spellingShingle Lina Mattson
Antonio Lentini
Danuta R. Gawel
Tejaswi V. S. Badam
Mikael Benson
Torbjorn Ledin
Colm E. Nestor
Mika Gustafsson
Jordi Serra-Musach
Janne Bjorkander
Zou Xiang
Huan Zhang
Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
Journal of Immunology Research
title Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
title_full Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
title_fullStr Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
title_full_unstemmed Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
title_short Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
title_sort potential involvement of type i interferon signaling in immunotherapy in seasonal allergic rhinitis
url http://dx.doi.org/10.1155/2016/5153184
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