The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents
Obesity is characterized by the accumulation of excessive fat, potentially leading to degenerative diseases. Pancreatic lipase, an enzyme responsible for converting 50–70% of dietary fat into monoglycerides, free fatty acids, and various other smaller molecules, plays a crucial role in fat metabolis...
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2025-01-01
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| Series: | Current Issues in Molecular Biology |
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| author | Min Rahminiwati Dyah Iswantini Trivadila Rut Novalia Rahmawati Sianipar Rani Melati Sukma Susi Indariani Anggia Murni |
| author_facet | Min Rahminiwati Dyah Iswantini Trivadila Rut Novalia Rahmawati Sianipar Rani Melati Sukma Susi Indariani Anggia Murni |
| author_sort | Min Rahminiwati |
| collection | DOAJ |
| description | Obesity is characterized by the accumulation of excessive fat, potentially leading to degenerative diseases. Pancreatic lipase, an enzyme responsible for converting 50–70% of dietary fat into monoglycerides, free fatty acids, and various other smaller molecules, plays a crucial role in fat metabolism. Therefore, this study aimed to review selected Indonesian medicinal plants with the potential to inhibit the activity of the pancreatic lipase enzyme. The results showed that kunci pepet (<i>Kaempferiae angustifolia</i> Rosc.), asam gelugur (<i>Garcinia atroviridis</i>), temulawak (<i>Curcuma xanthorrhiza</i>), jombang (<i>Taraxacum officinale</i> F. H. Wigg), pegagan (<i>Centella asiatica</i>), and pala (<i>Myristica fragrans</i>) had strong inhibitory effects, exceeding 50% for both in vitro and in vivo studies. Therefore, further studies are needed to explore the potential of these medicinal plants as anti-obesity treatments. |
| format | Article |
| id | doaj-art-e9431b34c8664eabac90398fd0f5b53e |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-e9431b34c8664eabac90398fd0f5b53e2025-01-24T13:27:29ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-01-014713910.3390/cimb47010039The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity AgentsMin Rahminiwati0Dyah Iswantini1Trivadila2Rut Novalia Rahmawati Sianipar3Rani Melati Sukma4Susi Indariani5Anggia Murni6School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor 16680, West Java, IndonesiaTropical Biopharmaca Research Center, IPB University, Bogor 16128, West Java, IndonesiaTropical Biopharmaca Research Center, IPB University, Bogor 16128, West Java, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, West Java, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, West Java, IndonesiaTropical Biopharmaca Research Center, IPB University, Bogor 16128, West Java, IndonesiaTropical Biopharmaca Research Center, IPB University, Bogor 16128, West Java, IndonesiaObesity is characterized by the accumulation of excessive fat, potentially leading to degenerative diseases. Pancreatic lipase, an enzyme responsible for converting 50–70% of dietary fat into monoglycerides, free fatty acids, and various other smaller molecules, plays a crucial role in fat metabolism. Therefore, this study aimed to review selected Indonesian medicinal plants with the potential to inhibit the activity of the pancreatic lipase enzyme. The results showed that kunci pepet (<i>Kaempferiae angustifolia</i> Rosc.), asam gelugur (<i>Garcinia atroviridis</i>), temulawak (<i>Curcuma xanthorrhiza</i>), jombang (<i>Taraxacum officinale</i> F. H. Wigg), pegagan (<i>Centella asiatica</i>), and pala (<i>Myristica fragrans</i>) had strong inhibitory effects, exceeding 50% for both in vitro and in vivo studies. Therefore, further studies are needed to explore the potential of these medicinal plants as anti-obesity treatments.https://www.mdpi.com/1467-3045/47/1/39Indonesianatural resourcesobesitypancreatic lipase enzyme |
| spellingShingle | Min Rahminiwati Dyah Iswantini Trivadila Rut Novalia Rahmawati Sianipar Rani Melati Sukma Susi Indariani Anggia Murni The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents Current Issues in Molecular Biology Indonesia natural resources obesity pancreatic lipase enzyme |
| title | The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents |
| title_full | The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents |
| title_fullStr | The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents |
| title_full_unstemmed | The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents |
| title_short | The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents |
| title_sort | strong inhibition of pancreatic lipase by selected indonesian medicinal plants as anti obesity agents |
| topic | Indonesia natural resources obesity pancreatic lipase enzyme |
| url | https://www.mdpi.com/1467-3045/47/1/39 |
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