Curcumin derivative C210 induces Epstein–Barr virus lytic cycle and inhibits virion production by disrupting Hsp90 function

Curcumin derivative C210 induces Epstein–Barr virus lytic cycle and inhibits virion production by disrupting Hsp90 function

Abstract Lytic induction therapy was devised to selectively combat malignancies associated with Epstein–Barr virus (EBV) by triggering viral reactivation from latency. At present, the major challenges of lytic induction therapy are to maximize reactivating efficiencies and meanwhile minimize infecti...

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Bibliographic Details
Main Authors: Linli Chen, Xiaojing Guo, Wen Lin, Yingying Huang, Suling Zhuang, Qianfeng Li, Jianhua Xu, Shengnan Ye
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Epstein–Barr virus
Curcumin derivative
Hsp90 inhibitor
Lytic induction therapy
Nasopharyngeal carcinoma
Gastric carcinoma
Online Access:https://doi.org/10.1038/s41598-024-77294-w
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