Spatial encoding in primate hippocampus during free navigation.
The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Her...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-12-01
|
| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3000546 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850077136842391552 |
|---|---|
| author | Hristos S Courellis Samuel U Nummela Michael Metke Geoffrey W Diehl Robert Bussell Gert Cauwenberghs Cory T Miller |
| author_facet | Hristos S Courellis Samuel U Nummela Michael Metke Geoffrey W Diehl Robert Bussell Gert Cauwenberghs Cory T Miller |
| author_sort | Hristos S Courellis |
| collection | DOAJ |
| description | The hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neural activity in the hippocampus of freely moving marmosets as they naturally explored a spatial environment to more explicitly investigate this issue. We report place cells in marmoset hippocampus during free navigation that exhibit remarkable parallels to analogous neurons in other mammalian species. Although θ oscillations were prevalent in the marmoset hippocampus, the patterns of activity were notably different than in other taxa. This local field potential oscillation occurred in short bouts (approximately .4 s)-rather than continuously-and was neither significantly modulated by locomotion nor consistently coupled to place-cell activity. These findings suggest that the relationship between place-cell activity and θ oscillations in primate hippocampus during free navigation differs substantially from rodents and paint an intriguing comparative picture regarding the neural basis of spatial navigation across mammals. |
| format | Article |
| id | doaj-art-e93e6cafccec40fbb8f9382bb22869b5 |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-e93e6cafccec40fbb8f9382bb22869b52025-08-20T02:45:52ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852019-12-011712e300054610.1371/journal.pbio.3000546Spatial encoding in primate hippocampus during free navigation.Hristos S CourellisSamuel U NummelaMichael MetkeGeoffrey W DiehlRobert BussellGert CauwenberghsCory T MillerThe hippocampus comprises two neural signals-place cells and θ oscillations-that contribute to facets of spatial navigation. Although their complementary relationship has been well established in rodents, their respective contributions in the primate brain during free navigation remains unclear. Here, we recorded neural activity in the hippocampus of freely moving marmosets as they naturally explored a spatial environment to more explicitly investigate this issue. We report place cells in marmoset hippocampus during free navigation that exhibit remarkable parallels to analogous neurons in other mammalian species. Although θ oscillations were prevalent in the marmoset hippocampus, the patterns of activity were notably different than in other taxa. This local field potential oscillation occurred in short bouts (approximately .4 s)-rather than continuously-and was neither significantly modulated by locomotion nor consistently coupled to place-cell activity. These findings suggest that the relationship between place-cell activity and θ oscillations in primate hippocampus during free navigation differs substantially from rodents and paint an intriguing comparative picture regarding the neural basis of spatial navigation across mammals.https://doi.org/10.1371/journal.pbio.3000546 |
| spellingShingle | Hristos S Courellis Samuel U Nummela Michael Metke Geoffrey W Diehl Robert Bussell Gert Cauwenberghs Cory T Miller Spatial encoding in primate hippocampus during free navigation. PLoS Biology |
| title | Spatial encoding in primate hippocampus during free navigation. |
| title_full | Spatial encoding in primate hippocampus during free navigation. |
| title_fullStr | Spatial encoding in primate hippocampus during free navigation. |
| title_full_unstemmed | Spatial encoding in primate hippocampus during free navigation. |
| title_short | Spatial encoding in primate hippocampus during free navigation. |
| title_sort | spatial encoding in primate hippocampus during free navigation |
| url | https://doi.org/10.1371/journal.pbio.3000546 |
| work_keys_str_mv | AT hristosscourellis spatialencodinginprimatehippocampusduringfreenavigation AT samuelunummela spatialencodinginprimatehippocampusduringfreenavigation AT michaelmetke spatialencodinginprimatehippocampusduringfreenavigation AT geoffreywdiehl spatialencodinginprimatehippocampusduringfreenavigation AT robertbussell spatialencodinginprimatehippocampusduringfreenavigation AT gertcauwenberghs spatialencodinginprimatehippocampusduringfreenavigation AT corytmiller spatialencodinginprimatehippocampusduringfreenavigation |