MyoD is essential in rhabdomyosarcoma by promoting survival through differentiation and CYLD

MyoD is essential in rhabdomyosarcoma by promoting survival through differentiation and CYLD

Summary: Rhabdomyosarcoma (RMS) is the most common soft tissue cancer among children, characterized by a skeletal muscle lineage that is impaired from undergoing terminal differentiation. NF-κB is constitutively active in cancer cells and plays a critical role in cell survival. Although NF-κB is als...

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Bibliographic Details
Main Authors: Alexander R. Oles, Peter Y. Yu, Abasi-ama Udeme, Sudarshana Sharma, Priya Londhe, Benjamin R. Pryce, Erin E. Talbert, Eric M. Hill, Carlos J. Miranda, Brian K. Kaspar, Michael A. Arnold, Jack Hyland, Cheryl A. London, Peter J. Houghton, David J. Wang, Ryan D. Roberts, Denis C. Guttridge
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014105
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