Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia
Background. The aim of the study was to investigate the association between single nucleotide polymorphism (SNP) of vitamin D receptor (VDR) gene and clinical progress of benign prostatic hyperplasia (BPH) in Chinese men. Methods. The DNA was extracted from blood of 200 BPH patients with operation (...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/235895 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564645576048640 |
|---|---|
| author | Li Ruan Jian-guo Zhu Cong Pan Xing Hua Dong-bo Yuan Zheng-ming Li Wei-de Zhong |
| author_facet | Li Ruan Jian-guo Zhu Cong Pan Xing Hua Dong-bo Yuan Zheng-ming Li Wei-de Zhong |
| author_sort | Li Ruan |
| collection | DOAJ |
| description | Background. The aim of the study was to investigate the association between single nucleotide polymorphism (SNP) of vitamin D receptor (VDR) gene and clinical progress of benign prostatic hyperplasia (BPH) in Chinese men. Methods. The DNA was extracted from blood of 200 BPH patients with operation (progression group) and 200 patients without operation (control group), respectively. The genotypes of VDR gene FokI SNP represented by “F/f” were identified by PCR-restriction fragment length polymorphism. The odds ratio (OR) of having progression of BPH for having the genotype were calculated. Results. Our date indicated that the f alleles of the VDR gene FokI SNP associated with the progression of BPH (P=0.009). Conclusion. For the first time, our study demonstrated that VDR gene FokI SNP may be associated with the risk of BPH progress. |
| format | Article |
| id | doaj-art-e93da0d819ae44fe8513ffc5d540ca6c |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e93da0d819ae44fe8513ffc5d540ca6c2025-02-03T01:10:33ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/235895235895Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic HyperplasiaLi Ruan0Jian-guo Zhu1Cong Pan2Xing Hua3Dong-bo Yuan4Zheng-ming Li5Wei-de Zhong6Department of Urology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, ChinaDepartment of Urology, Guizhou Provincial People’s Hospital, Guizhou 550002, ChinaGuizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang 550018, ChinaDepartment of Pathology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, ChinaDepartment of Urology, Guizhou Provincial People’s Hospital, Guizhou 550002, ChinaDepartment of Urology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, ChinaDepartment of Urology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 510180, ChinaBackground. The aim of the study was to investigate the association between single nucleotide polymorphism (SNP) of vitamin D receptor (VDR) gene and clinical progress of benign prostatic hyperplasia (BPH) in Chinese men. Methods. The DNA was extracted from blood of 200 BPH patients with operation (progression group) and 200 patients without operation (control group), respectively. The genotypes of VDR gene FokI SNP represented by “F/f” were identified by PCR-restriction fragment length polymorphism. The odds ratio (OR) of having progression of BPH for having the genotype were calculated. Results. Our date indicated that the f alleles of the VDR gene FokI SNP associated with the progression of BPH (P=0.009). Conclusion. For the first time, our study demonstrated that VDR gene FokI SNP may be associated with the risk of BPH progress.http://dx.doi.org/10.1155/2015/235895 |
| spellingShingle | Li Ruan Jian-guo Zhu Cong Pan Xing Hua Dong-bo Yuan Zheng-ming Li Wei-de Zhong Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia The Scientific World Journal |
| title | Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia |
| title_full | Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia |
| title_fullStr | Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia |
| title_full_unstemmed | Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia |
| title_short | Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia |
| title_sort | association between single nucleotide polymorphism of vitamin d receptor gene foki polymorphism and clinical progress of benign prostatic hyperplasia |
| url | http://dx.doi.org/10.1155/2015/235895 |
| work_keys_str_mv | AT liruan associationbetweensinglenucleotidepolymorphismofvitamindreceptorgenefokipolymorphismandclinicalprogressofbenignprostatichyperplasia AT jianguozhu associationbetweensinglenucleotidepolymorphismofvitamindreceptorgenefokipolymorphismandclinicalprogressofbenignprostatichyperplasia AT congpan associationbetweensinglenucleotidepolymorphismofvitamindreceptorgenefokipolymorphismandclinicalprogressofbenignprostatichyperplasia AT xinghua associationbetweensinglenucleotidepolymorphismofvitamindreceptorgenefokipolymorphismandclinicalprogressofbenignprostatichyperplasia AT dongboyuan associationbetweensinglenucleotidepolymorphismofvitamindreceptorgenefokipolymorphismandclinicalprogressofbenignprostatichyperplasia AT zhengmingli associationbetweensinglenucleotidepolymorphismofvitamindreceptorgenefokipolymorphismandclinicalprogressofbenignprostatichyperplasia AT weidezhong associationbetweensinglenucleotidepolymorphismofvitamindreceptorgenefokipolymorphismandclinicalprogressofbenignprostatichyperplasia |