A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center
Background: Rheumatoid arthritis (RA) is a chronic autoimmune condition often linked with depression, worsening symptoms, and lowering the quality of life. This study evaluated the prevalence of depression in female RA patients and its relationship with RA activity and inflammatory markers. Material...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1478_24 |
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| author | Hansraj Parmar Prakash Joshi Reena Singh Sachin Parmar Ranjana Sharma |
| author_facet | Hansraj Parmar Prakash Joshi Reena Singh Sachin Parmar Ranjana Sharma |
| author_sort | Hansraj Parmar |
| collection | DOAJ |
| description | Background:
Rheumatoid arthritis (RA) is a chronic autoimmune condition often linked with depression, worsening symptoms, and lowering the quality of life. This study evaluated the prevalence of depression in female RA patients and its relationship with RA activity and inflammatory markers.
Material and Methods:
A cross-sectional study was conducted over 18 months, involving 185 female RA patients with depression, diagnosed using DSM-5 criteria. RA disease activity was assessed using the Disease Activity Score 28 (DAS 28), and inflammatory markers, including CRP, ESR, RF, and anti-CCP, were evaluated. Data analysis was performed using SPSS version 20.0.
Results:
Depression was present in 72.4% of patients, with mild, moderate, and severe depression observed in 31.4%, 26.5%, and 14.6%, respectively. Significant associations were found between depression severity and RA activity (P = 0.000). Elevated CRP and ESR levels were seen in 81.6% and 89.7% of patients, correlating with depression severity. Rheumatoid markers (RF and Anti-CCP) were also significantly linked to both RA activity and depression.
Conclusion:
High depression prevalence in RA patients, especially those with severe disease activity, highlights the need for integrated mental health and RA care to enhance patient outcomes. |
| format | Article |
| id | doaj-art-e93c3fb3859e4efca16bdb32a22b2282 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-e93c3fb3859e4efca16bdb32a22b22822025-08-20T03:24:40ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S634S63710.4103/jpbs.jpbs_1478_24A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care CenterHansraj ParmarPrakash JoshiReena SinghSachin ParmarRanjana SharmaBackground: Rheumatoid arthritis (RA) is a chronic autoimmune condition often linked with depression, worsening symptoms, and lowering the quality of life. This study evaluated the prevalence of depression in female RA patients and its relationship with RA activity and inflammatory markers. Material and Methods: A cross-sectional study was conducted over 18 months, involving 185 female RA patients with depression, diagnosed using DSM-5 criteria. RA disease activity was assessed using the Disease Activity Score 28 (DAS 28), and inflammatory markers, including CRP, ESR, RF, and anti-CCP, were evaluated. Data analysis was performed using SPSS version 20.0. Results: Depression was present in 72.4% of patients, with mild, moderate, and severe depression observed in 31.4%, 26.5%, and 14.6%, respectively. Significant associations were found between depression severity and RA activity (P = 0.000). Elevated CRP and ESR levels were seen in 81.6% and 89.7% of patients, correlating with depression severity. Rheumatoid markers (RF and Anti-CCP) were also significantly linked to both RA activity and depression. Conclusion: High depression prevalence in RA patients, especially those with severe disease activity, highlights the need for integrated mental health and RA care to enhance patient outcomes.https://journals.lww.com/10.4103/jpbs.jpbs_1478_24crpdas 28depressiondisease activityesrrheumatoid arthritis |
| spellingShingle | Hansraj Parmar Prakash Joshi Reena Singh Sachin Parmar Ranjana Sharma A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center Journal of Pharmacy and Bioallied Sciences crp das 28 depression disease activity esr rheumatoid arthritis |
| title | A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center |
| title_full | A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center |
| title_fullStr | A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center |
| title_full_unstemmed | A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center |
| title_short | A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center |
| title_sort | cross sectional study of depression in rheumatoid arthritis patients at a tertiary care center |
| topic | crp das 28 depression disease activity esr rheumatoid arthritis |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1478_24 |
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