Predictive value of early MoCA score combined with serum S100 protein and 25⁃hydroxyvitamin D3 levels on secondary cognitive dysfunction in patients with cerebral infarction
Objective To explore the early Montreal Cognitive Assessment（MoCA）score and serum levels of S100 protein and 25 ⁃ hydroxyvitamin D3［25（OH）D3］in patients with cerebral infarction who had secondary cognitive dysfunction，and to analyze the predictive value of these three factors for secondary cognitive...
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| Format: | Article |
| Language: | zho |
| Published: |
The Editorial Department of Chinese Journal of Clinical Research
2025-08-01
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| Series: | Zhongguo linchuang yanjiu |
| Subjects: | |
| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250821 |
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| Summary: | Objective To explore the early Montreal Cognitive Assessment（MoCA）score and serum levels of S100 protein and 25 ⁃ hydroxyvitamin D3［25（OH）D3］in patients with cerebral infarction who had secondary cognitive dysfunction，and to analyze the predictive value of these three factors for secondary cognitive dysfunction in patients with cerebral infarction. Methods A total of 60 patients with cerebral infarction treated at Affiliated Changshu Hospital of Nantong University from March to June 2023 were selected. Patients were followed for 6 months and divided into two groups based on the presence of secondary cognitive dysfunction：the occurrence group（26 cases）and the non ⁃occurrence group（34 cases）. Early MoCA scores，serum levels of S100 protein，25（OH）D3，C⁃reactive protein（CRP），homocysteine（Hcy），and serum creatinine（Scr）were compared between the two groups. Multivariate logistic regression analysis was conducted to determine the influencing factors of secondary cognitive dysfunction in patients with cerebral infarction，and receiver operating characteristic（ROC）curve analysis was performed to assess predictive value of each index for cognitive dysfunction. Results Compared with the non⁃occurrence group，patients in the occurrence group had higher level of serum S100 protein［（0.62±0.16）μg/L vs（0.41±0.10）μg/L，t=6.233，P<0.01］and lower level of 25（OH）D3［（13.73±2.12）ng/mL vs（18.34±2.36）ng/mL，t=7.831，P<0.01］. Multivariate logistic regression analysis showed that high levels of CRP，Hcy and S100 protein，and lesions located in functional areas were risk factors for secondary cognitive dysfunction in patients with cerebral infarction，while high early MoCA scores and high 25（OH）D3 levels were protective factors（P<0.05）. ROC curve analysis indicated that the area under curve（AUC），specificity，and sensitivity of the combined detection were the highest among the single and combined detection of the three indicators.Conclusion Early MoCA scores，CRP，Hcy，S100 protein，and 25（OH）D3 are associated with secondary cognitive dysfunction in patients with cerebral infarction. Early MoCA scores combined with serum S100 protein and 25（OH）D3 measurements have certain predictive value for secondary cognitive dysfunction in these patients.
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| ISSN: | 1674-8182 |