Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases
The pathogenesis of autoimmune diseases includes a combination of genetic factors and environmental exposures including infectious agents. Infectious triggers are commonly indicated as being involved in the induction of autoimmune disease, with Epstein-Barr virus (EBV) being implicated in several au...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/987471 |
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| author | Eirini I. Rigopoulou Daniel S. Smyk Claire E. Matthews Charalambos Billinis Andrew K. Burroughs Marco Lenzi Dimitrios P. Bogdanos |
| author_facet | Eirini I. Rigopoulou Daniel S. Smyk Claire E. Matthews Charalambos Billinis Andrew K. Burroughs Marco Lenzi Dimitrios P. Bogdanos |
| author_sort | Eirini I. Rigopoulou |
| collection | DOAJ |
| description | The pathogenesis of autoimmune diseases includes a combination of genetic factors and environmental exposures including infectious agents. Infectious triggers are commonly indicated as being involved in the induction of autoimmune disease, with Epstein-Barr virus (EBV) being implicated in several autoimmune disorders. EBV is appealing in the pathogenesis of autoimmune disease, due to its high prevalence worldwide, its persistency throughout life in the host’s B lymphocytes, and its ability to alter the host’s immune response and to inhibit apoptosis. However, the evidence in support of EBV in the pathogenesis varies among diseases. Autoimmune liver diseases (AiLDs), including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), have a potential causative link with EBV. The data surrounding EBV and AiLD are scarce. The lack of evidence surrounding EBV in AiLD may also be reflective of the rarity of these conditions. EBV infection has also been linked to other autoimmune conditions, which are often found to be concomitant with AiLD. This paper will critically examine the literature surrounding the link between EBV infection and AiLD development. The current evidence is far from being conclusive of the theory of a link between EBV and AiLD. |
| format | Article |
| id | doaj-art-e938eb9cc54943028e942f4d7b5e47f8 |
| institution | OA Journals |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-e938eb9cc54943028e942f4d7b5e47f82025-08-20T02:21:53ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/987471987471Epstein-Barr Virus as a Trigger of Autoimmune Liver DiseasesEirini I. Rigopoulou0Daniel S. Smyk1Claire E. Matthews2Charalambos Billinis3Andrew K. Burroughs4Marco Lenzi5Dimitrios P. Bogdanos6Department of Medicine, University of Thessaly Medical School, Viopolis, 41110 Larissa, GreeceInstitute of Liver Studies and Liver Unit, King's College London School of Medicine, King's College Hospital, Denmark Hill Campus, London SE5 9RS, UKInstitute of Liver Studies and Liver Unit, King's College London School of Medicine, King's College Hospital, Denmark Hill Campus, London SE5 9RS, UKDepartment of Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, GreeceThe Sheila Sherlock Liver Centre and University Department of Surgery, Royal Free Hospital, London NW32QG, UKDepartment of Clinical Medicine, Alma Mater Studiorum, University of Bologna, Sant'Orsola-Malpighi Policlinic, Padiglione 11, 40138 Bologna, ItalyDepartment of Medicine, University of Thessaly Medical School, Viopolis, 41110 Larissa, GreeceThe pathogenesis of autoimmune diseases includes a combination of genetic factors and environmental exposures including infectious agents. Infectious triggers are commonly indicated as being involved in the induction of autoimmune disease, with Epstein-Barr virus (EBV) being implicated in several autoimmune disorders. EBV is appealing in the pathogenesis of autoimmune disease, due to its high prevalence worldwide, its persistency throughout life in the host’s B lymphocytes, and its ability to alter the host’s immune response and to inhibit apoptosis. However, the evidence in support of EBV in the pathogenesis varies among diseases. Autoimmune liver diseases (AiLDs), including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), have a potential causative link with EBV. The data surrounding EBV and AiLD are scarce. The lack of evidence surrounding EBV in AiLD may also be reflective of the rarity of these conditions. EBV infection has also been linked to other autoimmune conditions, which are often found to be concomitant with AiLD. This paper will critically examine the literature surrounding the link between EBV infection and AiLD development. The current evidence is far from being conclusive of the theory of a link between EBV and AiLD.http://dx.doi.org/10.1155/2012/987471 |
| spellingShingle | Eirini I. Rigopoulou Daniel S. Smyk Claire E. Matthews Charalambos Billinis Andrew K. Burroughs Marco Lenzi Dimitrios P. Bogdanos Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases Advances in Virology |
| title | Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases |
| title_full | Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases |
| title_fullStr | Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases |
| title_full_unstemmed | Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases |
| title_short | Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases |
| title_sort | epstein barr virus as a trigger of autoimmune liver diseases |
| url | http://dx.doi.org/10.1155/2012/987471 |
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