Anti Vascular Endothelial Growth Factor Agents in Corneal Neovascularization
Corneal neovascularisation is a potentially blinding condition, an established risk factor for rejection and results in loss of immune privilege. It may occur as a normal physiologic healing response to various stimuli or as an inappropriate local tissue response to primary insult arising due to an...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-07-01
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| Series: | Delhi Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/0972-0200.376568 |
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| _version_ | 1850143799830904832 |
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| author | Srivatsa Sehra Reetika |
| author_facet | Srivatsa Sehra Reetika |
| author_sort | Srivatsa Sehra |
| collection | DOAJ |
| description | Corneal neovascularisation is a potentially blinding condition, an established risk factor for rejection and results in loss of immune privilege. It may occur as a normal physiologic healing response to various stimuli or as an inappropriate local tissue response to primary insult arising due to an imbalance between the angiogenic and antiangiogenic factors present in the normally avascular cornea. Medical and surgical treatment modalities have been described for the condition but there is no established treatment protocol. Anti vascular endothelial growth factor (Anti VEGF) agents are increasingly being used for the condition. In this article, we have presented the pathogenesis of corneal neovascularisation, role of VEGF and discussed the emerging use of anti VEGF agents as a treatment modality. |
| format | Article |
| id | doaj-art-e938ced906b34462b44062947de68d4c |
| institution | OA Journals |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2011-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-e938ced906b34462b44062947de68d4c2025-08-20T02:28:33ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842011-07-01221515410.4103/0972-0200.376568Anti Vascular Endothelial Growth Factor Agents in Corneal NeovascularizationSrivatsa SehraReetikaCorneal neovascularisation is a potentially blinding condition, an established risk factor for rejection and results in loss of immune privilege. It may occur as a normal physiologic healing response to various stimuli or as an inappropriate local tissue response to primary insult arising due to an imbalance between the angiogenic and antiangiogenic factors present in the normally avascular cornea. Medical and surgical treatment modalities have been described for the condition but there is no established treatment protocol. Anti vascular endothelial growth factor (Anti VEGF) agents are increasingly being used for the condition. In this article, we have presented the pathogenesis of corneal neovascularisation, role of VEGF and discussed the emerging use of anti VEGF agents as a treatment modality.https://journals.lww.com/10.4103/0972-0200.376568corneal neovascularizationvascular endothelial growth factorbevacizumab |
| spellingShingle | Srivatsa Sehra Reetika Anti Vascular Endothelial Growth Factor Agents in Corneal Neovascularization Delhi Journal of Ophthalmology corneal neovascularization vascular endothelial growth factor bevacizumab |
| title | Anti Vascular Endothelial Growth Factor Agents in Corneal Neovascularization |
| title_full | Anti Vascular Endothelial Growth Factor Agents in Corneal Neovascularization |
| title_fullStr | Anti Vascular Endothelial Growth Factor Agents in Corneal Neovascularization |
| title_full_unstemmed | Anti Vascular Endothelial Growth Factor Agents in Corneal Neovascularization |
| title_short | Anti Vascular Endothelial Growth Factor Agents in Corneal Neovascularization |
| title_sort | anti vascular endothelial growth factor agents in corneal neovascularization |
| topic | corneal neovascularization vascular endothelial growth factor bevacizumab |
| url | https://journals.lww.com/10.4103/0972-0200.376568 |
| work_keys_str_mv | AT srivatsasehra antivascularendothelialgrowthfactoragentsincornealneovascularization AT reetika antivascularendothelialgrowthfactoragentsincornealneovascularization |