Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus
Aim. To study the effects of long6term carvedilol treatment on left ventricular (LV) remodeling and glycemia control parameters in patients with chronic heart failure (CHF) due to post6infarction cardiosclerosis, and Type 2 diabetes mellitus (DM-2).Material and methods. This 12-month study included...
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| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1062 |
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| author | R. R. Samedov A. B. Bakhshaliev |
| author_facet | R. R. Samedov A. B. Bakhshaliev |
| author_sort | R. R. Samedov |
| collection | DOAJ |
| description | Aim. To study the effects of long6term carvedilol treatment on left ventricular (LV) remodeling and glycemia control parameters in patients with chronic heart failure (CHF) due to post6infarction cardiosclerosis, and Type 2 diabetes mellitus (DM-2).Material and methods. This 12-month study included 30 patients with functional Class (FC) II-III CHF by NYHA classification, LV ejection fraction (EF) <40% and DM-2. Carvedilol was administered in the daily dose of 6,25-25 mg.Results. Carvedilol therapy was associated with substantial heart rate reduction: from 103,5±4,6 to 79,7±2,3 bpm (р<0,001). After 12 months, end-diastolic and end-systolic volumes decreased from 199,4±32,7 to 182,7±36,8and from 132,0±27,9 to 112,8±31,3 ml, respectively (р<0,001), LV EF increased from 34,22±3,80 to 39,04±5,39%. Carvedilol therapy did not affect glycemia levels: 178,0±12,97 mg/dl at baseline, 180,27±12,72 mg/dl in the end of the study (р>0,05).Conclusion. Long-term carvedilol therapy was associated with improved clinic and hemodynamic status, as well as delayed LV remodeling, without affecting glycemia levels in patients with CHF and DM-2. |
| format | Article |
| id | doaj-art-e9384f31e6c444098cdf41ad5adbceec |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2008-02-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-e9384f31e6c444098cdf41ad5adbceec2025-08-20T03:43:27Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-02-01715962775Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitusR. R. Samedov0A. B. Bakhshaliev1Academician D.M. Abdullaev Research Institute of Cardiology. BakuAcademician D.M. Abdullaev Research Institute of Cardiology. BakuAim. To study the effects of long6term carvedilol treatment on left ventricular (LV) remodeling and glycemia control parameters in patients with chronic heart failure (CHF) due to post6infarction cardiosclerosis, and Type 2 diabetes mellitus (DM-2).Material and methods. This 12-month study included 30 patients with functional Class (FC) II-III CHF by NYHA classification, LV ejection fraction (EF) <40% and DM-2. Carvedilol was administered in the daily dose of 6,25-25 mg.Results. Carvedilol therapy was associated with substantial heart rate reduction: from 103,5±4,6 to 79,7±2,3 bpm (р<0,001). After 12 months, end-diastolic and end-systolic volumes decreased from 199,4±32,7 to 182,7±36,8and from 132,0±27,9 to 112,8±31,3 ml, respectively (р<0,001), LV EF increased from 34,22±3,80 to 39,04±5,39%. Carvedilol therapy did not affect glycemia levels: 178,0±12,97 mg/dl at baseline, 180,27±12,72 mg/dl in the end of the study (р>0,05).Conclusion. Long-term carvedilol therapy was associated with improved clinic and hemodynamic status, as well as delayed LV remodeling, without affecting glycemia levels in patients with CHF and DM-2.https://cardiovascular.elpub.ru/jour/article/view/1062type 2 diabetes mellituschronic heart failurebeta-adrenoblockerscarvedilol |
| spellingShingle | R. R. Samedov A. B. Bakhshaliev Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus Кардиоваскулярная терапия и профилактика type 2 diabetes mellitus chronic heart failure beta-adrenoblockers carvedilol |
| title | Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus |
| title_full | Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus |
| title_fullStr | Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus |
| title_full_unstemmed | Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus |
| title_short | Long-term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and Type 2 diabetes mellitus |
| title_sort | long term carvedilol therapy effects on left ventricular remodeling and glycemia in patients with chronic heart failure and type 2 diabetes mellitus |
| topic | type 2 diabetes mellitus chronic heart failure beta-adrenoblockers carvedilol |
| url | https://cardiovascular.elpub.ru/jour/article/view/1062 |
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