Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats
We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with kon...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/134575 |
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| author | Chuan-Chih Hsu Li-Fan Chen Mao-Tsun Lin Yu-Feng Tian |
| author_facet | Chuan-Chih Hsu Li-Fan Chen Mao-Tsun Lin Yu-Feng Tian |
| author_sort | Chuan-Chih Hsu |
| collection | DOAJ |
| description | We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with konokiol (0.5–5 mg/ml/kg) (HSDR+H). Sixty minutes before the start of heat stress, honokiol or vehicle solution was administered. (HSDR+H) significantly (a) attenuated hyperthermia, hypotension and hypothalamic ischemia, hypoxia, and neuronal apoptosis; (b) reduced the plasma index of the toxic oxidizing radicals; (c) diminished the indices of hepatic and renal dysfunction; (d) attenuated the plasma systemic inflammatory response molecules; (e) promoted plasma levels of an anti-inflammatory cytokine; (f) reduced the index of infiltration of polymorphonuclear neutrophils in the serum; and (g) promoted the survival time fourfold compared with the (HSDR+V) group. In conclusion, honokiol protected against the outcome of heatstroke by reducing inflammation and oxidative stress-mediated multiple organ dysfunction in diabetic rats. |
| format | Article |
| id | doaj-art-e9383522690c434e8310d46402248a1b |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e9383522690c434e8310d46402248a1b2025-08-20T02:21:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/134575134575Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic RatsChuan-Chih Hsu0Li-Fan Chen1Mao-Tsun Lin2Yu-Feng Tian3Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 112, TaiwanNursing Department, Cheng Kung University Hospital, Tainan 701, TaiwanDepartment of Medical Research, Chi Mei Medical Center, Tainan 710, TaiwanDepartment of Surgery, Chi Mei Medical Center, Tainan 710, TaiwanWe aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with konokiol (0.5–5 mg/ml/kg) (HSDR+H). Sixty minutes before the start of heat stress, honokiol or vehicle solution was administered. (HSDR+H) significantly (a) attenuated hyperthermia, hypotension and hypothalamic ischemia, hypoxia, and neuronal apoptosis; (b) reduced the plasma index of the toxic oxidizing radicals; (c) diminished the indices of hepatic and renal dysfunction; (d) attenuated the plasma systemic inflammatory response molecules; (e) promoted plasma levels of an anti-inflammatory cytokine; (f) reduced the index of infiltration of polymorphonuclear neutrophils in the serum; and (g) promoted the survival time fourfold compared with the (HSDR+V) group. In conclusion, honokiol protected against the outcome of heatstroke by reducing inflammation and oxidative stress-mediated multiple organ dysfunction in diabetic rats.http://dx.doi.org/10.1155/2014/134575 |
| spellingShingle | Chuan-Chih Hsu Li-Fan Chen Mao-Tsun Lin Yu-Feng Tian Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats International Journal of Endocrinology |
| title | Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats |
| title_full | Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats |
| title_fullStr | Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats |
| title_full_unstemmed | Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats |
| title_short | Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats |
| title_sort | honokiol protected against heatstroke induced oxidative stress and inflammation in diabetic rats |
| url | http://dx.doi.org/10.1155/2014/134575 |
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