Clinical and microbiological profile of spondylodiscitis: a retrospective analysis
Abstract Background Spondylodiscitis is a rare infectious disease with rising incidence in recent years. From 2005 till 2021 the incidence of Spondylodiscitis rose by 104%. Given its potential to cause complications and mortality, it demands greater attention. Epidemiological data and predisposing f...
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BMC
2025-05-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08748-z |
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| author | Ghazaleh Golchoub Ida Hosseini Amirali Alamdari Shabboo Ansari Farid Javandoust Gharehbagh Mahboobeh Taheri Ilad Alavi Darazam |
| author_facet | Ghazaleh Golchoub Ida Hosseini Amirali Alamdari Shabboo Ansari Farid Javandoust Gharehbagh Mahboobeh Taheri Ilad Alavi Darazam |
| author_sort | Ghazaleh Golchoub |
| collection | DOAJ |
| description | Abstract Background Spondylodiscitis is a rare infectious disease with rising incidence in recent years. From 2005 till 2021 the incidence of Spondylodiscitis rose by 104%. Given its potential to cause complications and mortality, it demands greater attention. Epidemiological data and predisposing factors can vary significantly across different geographical regions, suggesting that data from Iran may differ from those in other parts of the world. This study aims to evaluate the demographic, clinical, laboratory, and imaging characteristics of spondylodiscitis patients treated at Loghman Hakim Hospital in Tehran. Additionally, it seeks to analyze the treatment outcomes and complications associated with the disease. Methods We conducted a retrospective analysis of 65 adult patients diagnosed with spondylodiscitis over the past decade (2012–2022). The data collected encompassed demographic characteristics, underlying diseases, clinical presentations, laboratory and radiological findings, microbiological results, treatment approaches, and outcomes. Results The study included 65 adult patients with a mean age of 55.12 years, showing a slight male predominance (58.5%). Spondylodiscitis was community-acquired in 49.2% of cases and hospital-acquired postoperatively in 50.8%. The lumbosacral spine was the most affected region (47.4%). Staphylococcus aureus was the most frequently isolated microorganism (28.2%), followed by Mycobacterium tuberculosis. Complications included abscess formation in 49.2% of patients and multiorgan failure in 6.2%, resulting in death. Treatment primarily involved antibiotic therapy, with surgical intervention in select cases. Poor outcomes were observed in patients with unidentified microorganisms and those with longer delays in diagnosis. Conclusions Spondylodiscitis is associated with significant morbidity and a high rate of complications, particularly in cases with delayed diagnosis. Early diagnosis, appropriate antimicrobial therapy, and surgical intervention when necessary are crucial for improving patient outcomes. This study highlights the need for ongoing research to optimize diagnostic pathways and develop long-term management strategies for spondylodiscitis. |
| format | Article |
| id | doaj-art-e931ad568d9246c0b72ee6523eaf5b8a |
| institution | OA Journals |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-e931ad568d9246c0b72ee6523eaf5b8a2025-08-20T02:00:08ZengBMCBMC Musculoskeletal Disorders1471-24742025-05-012611710.1186/s12891-025-08748-zClinical and microbiological profile of spondylodiscitis: a retrospective analysisGhazaleh Golchoub0Ida Hosseini1Amirali Alamdari2Shabboo Ansari3Farid Javandoust Gharehbagh4Mahboobeh Taheri5Ilad Alavi Darazam6School of Medicine, Shahid Beheshti University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical SciencesDepartment of Community Medicine, Shahid Beheshti University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical SciencesAbstract Background Spondylodiscitis is a rare infectious disease with rising incidence in recent years. From 2005 till 2021 the incidence of Spondylodiscitis rose by 104%. Given its potential to cause complications and mortality, it demands greater attention. Epidemiological data and predisposing factors can vary significantly across different geographical regions, suggesting that data from Iran may differ from those in other parts of the world. This study aims to evaluate the demographic, clinical, laboratory, and imaging characteristics of spondylodiscitis patients treated at Loghman Hakim Hospital in Tehran. Additionally, it seeks to analyze the treatment outcomes and complications associated with the disease. Methods We conducted a retrospective analysis of 65 adult patients diagnosed with spondylodiscitis over the past decade (2012–2022). The data collected encompassed demographic characteristics, underlying diseases, clinical presentations, laboratory and radiological findings, microbiological results, treatment approaches, and outcomes. Results The study included 65 adult patients with a mean age of 55.12 years, showing a slight male predominance (58.5%). Spondylodiscitis was community-acquired in 49.2% of cases and hospital-acquired postoperatively in 50.8%. The lumbosacral spine was the most affected region (47.4%). Staphylococcus aureus was the most frequently isolated microorganism (28.2%), followed by Mycobacterium tuberculosis. Complications included abscess formation in 49.2% of patients and multiorgan failure in 6.2%, resulting in death. Treatment primarily involved antibiotic therapy, with surgical intervention in select cases. Poor outcomes were observed in patients with unidentified microorganisms and those with longer delays in diagnosis. Conclusions Spondylodiscitis is associated with significant morbidity and a high rate of complications, particularly in cases with delayed diagnosis. Early diagnosis, appropriate antimicrobial therapy, and surgical intervention when necessary are crucial for improving patient outcomes. This study highlights the need for ongoing research to optimize diagnostic pathways and develop long-term management strategies for spondylodiscitis.https://doi.org/10.1186/s12891-025-08748-zSpondylodiscitisSpinal InfectionsMicrobiological AnalysisClinical CharacteristicsTreatment OutcomesEpidemiology |
| spellingShingle | Ghazaleh Golchoub Ida Hosseini Amirali Alamdari Shabboo Ansari Farid Javandoust Gharehbagh Mahboobeh Taheri Ilad Alavi Darazam Clinical and microbiological profile of spondylodiscitis: a retrospective analysis BMC Musculoskeletal Disorders Spondylodiscitis Spinal Infections Microbiological Analysis Clinical Characteristics Treatment Outcomes Epidemiology |
| title | Clinical and microbiological profile of spondylodiscitis: a retrospective analysis |
| title_full | Clinical and microbiological profile of spondylodiscitis: a retrospective analysis |
| title_fullStr | Clinical and microbiological profile of spondylodiscitis: a retrospective analysis |
| title_full_unstemmed | Clinical and microbiological profile of spondylodiscitis: a retrospective analysis |
| title_short | Clinical and microbiological profile of spondylodiscitis: a retrospective analysis |
| title_sort | clinical and microbiological profile of spondylodiscitis a retrospective analysis |
| topic | Spondylodiscitis Spinal Infections Microbiological Analysis Clinical Characteristics Treatment Outcomes Epidemiology |
| url | https://doi.org/10.1186/s12891-025-08748-z |
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