Impact of intra-articular high-concentration hyaluronic acid administration on the innate immune response in experimental knee osteoarthritis

Impact of intra-articular high-concentration hyaluronic acid administration on the innate immune response in experimental knee osteoarthritis

Abstract Background Osteoarthritis (OA) is characterized by a loss of the joint viscoelastic properties. Hyaluronic acid (HA) intraarticular injections restore viscoelasticity, alleviating pain and improving patient function. Larger amounts of HA in a single injection could lead to greater efficacy,...

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Bibliographic Details
Main Authors: Gabriel Herrero-Beaumont, Miguel Marco-Bonilla, Alberto Migliore, Alberto López-Reyes, Alberto Irigaray-Moreno, Aránzazu Mediero, Raquel Largo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoarthritis
Hyaluronic acid
Cartilage damage, synovitis
Innate immune response
Online Access:https://doi.org/10.1186/s12891-025-09061-5
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