Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma
Early recurrence is common after curative hepatectomy for hepatocellular carcinoma and is associated with poor prognosis. This study aimed to identify risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma. Overall, 63 patients who underwent curative hepatectomy for...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-10-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317720863 |
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| author | Young Mi Hong Mong Cho Ki Tae Yoon Chong Woo Chu Kwang Ho Yang Yong Mok Park Je Ho Rhu |
| author_facet | Young Mi Hong Mong Cho Ki Tae Yoon Chong Woo Chu Kwang Ho Yang Yong Mok Park Je Ho Rhu |
| author_sort | Young Mi Hong |
| collection | DOAJ |
| description | Early recurrence is common after curative hepatectomy for hepatocellular carcinoma and is associated with poor prognosis. This study aimed to identify risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma. Overall, 63 patients who underwent curative hepatectomy for hepatocellular carcinoma were enrolled. Patients were divided into the early recurrence group, who developed recurrence within 12 months after hepatectomy (n = 10), and the non-early recurrence group (n = 53). Clinicopathological factors of early recurrence were retrospectively analyzed. Among the 63 patients, 10 (15.9%) patients experienced early recurrence. Univariate analysis showed tumor necrosis (p = 0.012), level of PIVKA-II (prothrombin induced by vitamin K absence or antagonist-II; p = 0.002), and microvascular invasion (p = 0.029) to be associated with early recurrence. By multivariate analysis, there were significant differences in high PIVKA-II (p < 0.001) and tumor necrosis (p = 0.012) in patients with early recurrence. The optimal cutoff values of PIVKA-II and tumor necrosis were 46 mAU/mL and 3% of total tumor volume, respectively. Patients with a high preoperative PIVKA-II level and extent of tumor necrosis, which are independent risk factors for early recurrence, should be actively treated and monitored closely after hepatectomy. |
| format | Article |
| id | doaj-art-e930c9f1c3284e8c80800e8babe9074a |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-e930c9f1c3284e8c80800e8babe9074a2025-08-20T02:50:59ZengSAGE PublishingTumor Biology1423-03802017-10-013910.1177/1010428317720863Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinomaYoung Mi Hong0Mong Cho1Ki Tae Yoon2Chong Woo Chu3Kwang Ho Yang4Yong Mok Park5Je Ho Rhu6Department of Internal Medicine, College of Medicine Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Internal Medicine, College of Medicine Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Internal Medicine, College of Medicine Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, College of Medicine Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, College of Medicine Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, College of Medicine Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, College of Medicine Pusan National University, Pusan National University Yangsan Hospital, Yangsan, Republic of KoreaEarly recurrence is common after curative hepatectomy for hepatocellular carcinoma and is associated with poor prognosis. This study aimed to identify risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma. Overall, 63 patients who underwent curative hepatectomy for hepatocellular carcinoma were enrolled. Patients were divided into the early recurrence group, who developed recurrence within 12 months after hepatectomy (n = 10), and the non-early recurrence group (n = 53). Clinicopathological factors of early recurrence were retrospectively analyzed. Among the 63 patients, 10 (15.9%) patients experienced early recurrence. Univariate analysis showed tumor necrosis (p = 0.012), level of PIVKA-II (prothrombin induced by vitamin K absence or antagonist-II; p = 0.002), and microvascular invasion (p = 0.029) to be associated with early recurrence. By multivariate analysis, there were significant differences in high PIVKA-II (p < 0.001) and tumor necrosis (p = 0.012) in patients with early recurrence. The optimal cutoff values of PIVKA-II and tumor necrosis were 46 mAU/mL and 3% of total tumor volume, respectively. Patients with a high preoperative PIVKA-II level and extent of tumor necrosis, which are independent risk factors for early recurrence, should be actively treated and monitored closely after hepatectomy.https://doi.org/10.1177/1010428317720863 |
| spellingShingle | Young Mi Hong Mong Cho Ki Tae Yoon Chong Woo Chu Kwang Ho Yang Yong Mok Park Je Ho Rhu Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma Tumor Biology |
| title | Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma |
| title_full | Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma |
| title_fullStr | Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma |
| title_full_unstemmed | Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma |
| title_short | Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma |
| title_sort | risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma |
| url | https://doi.org/10.1177/1010428317720863 |
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